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Protein Page:
VLDLR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VLDLR Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex
Molecular Function: very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding
Biological Process: nervous system development; receptor-mediated endocytosis; cholesterol metabolic process; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; signal transduction; lipid transport; memory
Reference #:  P98155 (UniProtKB)
Alt. Names/Synonyms: CARMQ1; CHRMQ1; FLJ35024; very low density lipoprotein receptor; Very low-density lipoprotein receptor; VLDL receptor; VLDL-R; VLDLR; VLDLRCH
Gene Symbols: VLDLR
Molecular weight: 96,098 Da
Basal Isoelectric point: 4.62  Predict pI for various phosphorylation states
Select Structure to View Below

VLDLR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T71-ga EKNCVKKtCAESDFV
0 1 T277-ga EVNCPSRtCRPDQFE
0 2 K828-u NWQHKNMkSMNFDNP
0 23 Y837-p MNFDNPVyLkTTEED
0 10 K839-u FDNPVyLkTTEEDLs
0 1 S846-p kTTEEDLsIDIGRHS
  mouse

 
T71 EKNCVKKTCAESDFV
T277 EVNCPSRTCRPDQFE
K828-u NWQHKNMkSMNFDNP
Y837 MNFDNPVYLkTTEED
K839-u FDNPVYLkTTEEDLS
S846 kTTEEDLSIDIGRHS
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