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Protein Page:
RAB25 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAB25 Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP- dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; pseudopodium
Molecular Function: protein binding; GTP binding
Biological Process: protein transport; small GTPase mediated signal transduction; positive regulation of cell proliferation; pseudopodium organization and biogenesis
Reference #:  P57735 (UniProtKB)
Alt. Names/Synonyms: CATX-8; CATX8; RAB11C; RAB25; RAB25, member RAS oncogene family; Ras-related protein Rab-25
Gene Symbols: RAB25
Molecular weight: 23,496 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RAB25

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y9-p GNGTEEDyNFVFKVV
0 1 T58 TRTVMLGTAAVKAQI
0 6 S79-p ERYRAITsAYYRGAV
0 1 K206-ub QEPGPGEkRACCISL
  mouse

 
Y9 GNRTDEDYNFVFKVV
T58-p TRTVMLGtAAVKAQI
S79-p ERYRAITsAYYRGAV
K206 QDPGPGEKRACCISL
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