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Protein Page:
CRYAB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CRYAB a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Note: This description may include information from UniProtKB.
Protein type: Heat shock protein; Chaperone
Cellular Component: microtubule cytoskeleton; Golgi apparatus; cell surface; mitochondrion; cytoplasm; plasma membrane; actin filament bundle; cytosol; Z disc; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; microtubule binding; metal ion binding; unfolded protein binding; structural constituent of eye lens
Biological Process: lens development in camera-type eye; muscle development; protein folding; microtubule polymerization or depolymerization; stress-activated MAPK cascade; glucose metabolic process; negative regulation of caspase activity; response to estradiol stimulus; tubulin folding; response to hydrogen peroxide; muscle contraction; negative regulation of intracellular transport; response to hypoxia; negative regulation of cell growth; protein homooligomerization; negative regulation of apoptosis; aging
Reference #:  P02511 (UniProtKB)
Alt. Names/Synonyms: alpha B crystallin; alpha crystallin B chain; Alpha(B)-crystallin; Alpha-crystallin B chain; CRYA2; CRYAB; crystallin, alpha B; CTPP2; Heat shock protein beta-5; heat-shock 20 kD like-protein; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
Gene Symbols: CRYAB
Molecular weight: 20,159 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CRYAB

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S19‑p, S45‑p, S59‑p
intracellular localization: S19‑p, S45‑p, S59‑p
molecular association, regulation: S19‑p, S45‑p, S59‑p
protein conformation: S19‑p, S45‑p, S59‑p
protein degradation: S19‑p, S45‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
20 11 S19-p RPFFPFHsPsrLFDQ
0 5 S21-p FFPFHsPsrLFDQFF
0 1 R22-me FPFHsPsrLFDQFFG
1 0 S35 FGEHLLESDLFPTST
1 2 S43-p DLFPTSTsLsPFYLr
29 6 S45-p FPTSTsLsPFYLrPP
0 1 R50-me sLsPFYLrPPsFLRA
0 2 S53-p PFYLrPPsFLRAPsW
35 13 S59-p PsFLRAPsWFDTGLS
0 1 T63 RAPsWFDTGLSEMRL
0 1 K72 LSEMRLEKDrFsVNL
0 1 R74-m1 EMRLEKDrFsVNLDV
0 2 S76-p RLEKDrFsVNLDVKH
0 2 K82 FsVNLDVKHFSPEEL
0 1 K90 HFSPEELKVkVLGDV
0 8 K90 HFSPEELKVkVLGDV
3 2 K92-ac SPEELKVkVLGDVIE
0 10 K92 SPEELKVKVLGDVIE
0 1 K103 DVIEVHGKHEERQDE
0 2 T132-p PADVDPLtItssLSS
0 1 T134-p DVDPLtItssLSSDG
0 1 S135-p VDPLtItssLSSDGV
0 1 S136-p DPLtItssLSSDGVL
0 1 T144-p LSSDGVLtVNGPRKQ
0 1 K150 LtVNGPRKQVSGPER
0 1 S153 NGPRKQVSGPERtIP
0 2 T158-p QVSGPERtIPITREE
1 0 K166-ac IPITREEkPAVTAAP
0 8 K166 IPITREEKPAVTAAP
3 1 T170 REEkPAVTAAPKK__
0 5 K174 PAVTAAPKK______
0 3 K175 AVTAAPKK_______
  mouse

 
S19-p RPFFPFHsPsRLFDQ
S21-p FFPFHsPsRLFDQFF
R22 FPFHsPsRLFDQFFG
S35 FGEHLLESDLFSTAT
S43 DLFSTATSLsPFYLR
S45-p FSTATSLsPFYLRPP
R50 SLsPFYLRPPSFLRA
S53 PFYLRPPSFLRAPsW
S59-p PSFLRAPsWIDtGLS
T63-p RAPsWIDtGLSEMRL
K72-ub LSEMRLEkDRFSVNL
R74 EMRLEkDRFSVNLDV
S76 RLEkDRFSVNLDVkH
K82-ub FSVNLDVkHFSPEEL
K90 HFSPEELKVkVLGDV
K90-ub HFSPEELkVkVLGDV
K92 SPEELkVKVLGDVIE
K92-ub SPEELkVkVLGDVIE
K103-ub DVIEVHGkHEERQDE
T132 PADVDPLTITSSLSS
T134 DVDPLTITSSLSSDG
S135 VDPLTITSSLSSDGV
S136 DPLTITSSLSSDGVL
T144 LSSDGVLTVNGPRkQ
K150-ub LTVNGPRkQVSGPER
S153 NGPRkQVSGPERtIP
T158-p QVSGPERtIPITREE
K166 IPITREEKPAVAAAP
K166-ub IPITREEkPAVAAAP
A170 REEkPAVAAAPkk__
K174-ub PAVAAAPkk______
K175-ub AVAAAPkk_______
  rat

 
S19-p RPFFPFHsPSRLFDQ
S21 FFPFHsPSRLFDQFF
R22 FPFHsPSRLFDQFFG
S35 FGEHLLESDLFSTAT
S43 DLFSTATSLsPFYLR
S45-p FSTATSLsPFYLRPP
R50 SLsPFYLRPPSFLRA
S53 PFYLRPPSFLRAPsW
S59-p PSFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRM
K72 LSEMRMEKDRFSVNL
R74 EMRMEKDRFSVNLDV
S76 RMEKDRFSVNLDVKH
K82 FSVNLDVKHFSPEEL
K90 HFSPEELKVKVLGDV
K90 HFSPEELKVKVLGDV
K92 SPEELKVKVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132 PADVDPLTITSSLSS
T134 DVDPLTITSSLSSDG
S135 VDPLTITSSLSSDGV
S136 DPLTITSSLSSDGVL
T144 LSSDGVLTVNGPRKQ
K150 LTVNGPRKQASGPER
S153 NGPRKQASGPERTIP
T158 QASGPERTIPITREE
K166 IPITREEKPAVtAAP
K166 IPITREEKPAVtAAP
T170-gl REEKPAVtAAPKK__
K174 PAVtAAPKK______
K175 AVtAAPKK_______
  rabbit

 
S19-p RPFFPFHsPsRLFDQ
S21-p FFPFHsPsRLFDQFF
R22 FPFHsPsRLFDQFFG
S35 FGEHLLESDLFPTST
S43 DLFPTSTSLsPFYLR
S45-p FPTSTSLsPFYLRPP
R50 SLsPFYLRPPSFLRA
S53 PFYLRPPSFLRAPsW
S59-p PSFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRL
K72 LSEMRLEKDRFSVNL
R74 EMRLEKDRFSVNLDV
S76 RLEKDRFSVNLDVKH
K82 FSVNLDVKHFSPEEL
K90 HFSPEELKVKVLGDV
K90 HFSPEELKVKVLGDV
K92 SPEELKVKVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132 PADVDPLTITSSLSS
T134 DVDPLTITSSLSSDG
S135 VDPLTITSSLSSDGV
S136 DPLTITSSLSSDGVL
T144 LSSDGVLTVNGPRKQ
K150 LTVNGPRKQAPGPER
P153 NGPRKQAPGPERTIP
T158 QAPGPERTIPITREE
K166 IPITREEKPAVTAAP
K166 IPITREEKPAVTAAP
T170 REEKPAVTAAPKK__
K174 PAVTAAPKK______
K175 AVTAAPKK_______
  pig

 
S19 RPFFPFHSPSRLFDQ
S21 FFPFHSPSRLFDQFF
R22 FPFHSPSRLFDQFFG
S35 FGEHLLESDLFPAST
S43 DLFPASTSLSPFYFR
S45 FPASTSLSPFYFRPP
R50 SLSPFYFRPPSFLRA
S53 PFYFRPPSFLRAPsW
S59-p PSFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRL
K72 LSEMRLEKDRFSVNL
R74 EMRLEKDRFSVNLDV
S76 RLEKDRFSVNLDVKH
K82 FSVNLDVKHFSPEEL
K90 HFSPEELKVKVLGDV
K90 HFSPEELKVKVLGDV
K92 SPEELKVKVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132 PADVDPLTITSSLSS
T134 DVDPLTITSSLSSDG
S135 VDPLTITSSLSSDGV
S136 DPLTITSSLSSDGVL
T144 LSSDGVLTVNGPRRQ
R150 LTVNGPRRQASGPER
S153 NGPRRQASGPERTIP
T158 QASGPERTIPITREE
K166 IPITREEKPAVTAAP
K166 IPITREEKPAVTAAP
T170 REEKPAVTAAPKK__
K174 PAVTAAPKK______
K175 AVTAAPKK_______
  cow

 
S19-p RPFFPFHsPsRLFDQ
S21-p FFPFHsPsRLFDQFF
R22 FPFHsPsRLFDQFFG
S35-p FGEHLLEsDLFPAST
S43-p DLFPASTsLsPFYLR
S45-p FPASTsLsPFYLRPP
R50 sLsPFYLRPPsFLRA
S53-p PFYLRPPsFLRAPsW
S59-p PsFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRL
K72 LSEMRLEKDRFsVNL
R74 EMRLEKDRFsVNLDV
S76-p RLEKDRFsVNLDVKH
K82 FsVNLDVKHFSPEEL
K90-ac HFSPEELkVkVLGDV
K90 HFSPEELKVkVLGDV
K92-ac SPEELkVkVLGDVIE
K92 SPEELkVKVLGDVIE
K103 DVIEVHGKHEERQDE
A132 PADVDPLAITSSLSS
T134 DVDPLAITSSLSSDG
S135 VDPLAITSSLSSDGV
S136 DPLAITSSLSSDGVL
T144 LSSDGVLTVNGPRKQ
K150 LTVNGPRKQAsGPER
S153-p NGPRKQAsGPERTIP
T158 QAsGPERTIPITREE
K166 IPITREEKPAVtAAP
K166 IPITREEKPAVtAAP
T170-gl REEKPAVtAAPKK__
K174 PAVtAAPKK______
K175 AVtAAPKK_______
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