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Protein Page:
VCAM1 (human)

Overview
VCAM1 Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium
Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding
Biological Process: response to nicotine; regulation of immune response; extracellular matrix organization and biogenesis; chronic inflammatory response; viral reproduction; heart development; cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; leukocyte tethering or rolling; cell adhesion; acute inflammatory response; response to nutrient; aging
Reference #:  P19320 (UniProtKB)
Alt. Names/Synonyms: CD106; CD106 antigen; DKFZp779G2333; INCAM-100; L1CAM; MGC99561; V-CAM 1; vascular cell adhesion molecule 1; Vascular cell adhesion protein 1; VCAM-1; VCAM1
Gene Symbols: VCAM1
Molecular weight: 81,276 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VCAM1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 E166 MKSQEFLEDADRKSL
0 1 R170 EFLEDADRKSLETKS
0 3 Y703-p SPELLVLyFAssLII
0 1 S706-p LLVLyFAssLIIPAI
0 1 S707-p LVLyFAssLIIPAIG
0 2 Y718-p PAIGMIIyFARKANM
  mouse

 
S166-p MNRQEFSsEEMtKSL
T170-p EFSsEEMtKSLETKS
Y703 SPELLALYCASSLVI
S706 LLALYCASSLVIPAI
S707 LALYCASSLVIPAIG
Y718 PAIGMIVYFARKANM
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