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Protein Page:
VCAM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VCAM1 Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium
Molecular Function: amine oxidase activity; integrin binding; cell adhesion molecule binding
Biological Process: response to nicotine; regulation of immune response; chronic inflammatory response; extracellular matrix organization and biogenesis; viral reproduction; cytokine and chemokine mediated signaling pathway; heart development; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; response to nutrient; acute inflammatory response; aging
Reference #:  P19320 (UniProtKB)
Alt. Names/Synonyms: CD106; CD106 antigen; DKFZp779G2333; INCAM-100; L1CAM; MGC99561; V-CAM 1; vascular cell adhesion molecule 1; Vascular cell adhesion protein 1; VCAM-1; VCAM1
Gene Symbols: VCAM1
Molecular weight: 81,276 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VCAM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 E166 MKSQEFLEDADRKSL
0 1 R170 EFLEDADRKSLETKS
0 1 F494 LHIDDMEFEPKQRQS
0 1 Y653-p LKSIDGAyTIRKAQL
0 3 Y703-p SPELLVLyFAssLII
0 1 S706-p LLVLyFAssLIIPAI
0 1 S707-p LVLyFAssLIIPAIG
0 2 Y718-p PAIGMIIyFARKANM
0 1 K736 YSLVEAQKSKV____
  mouse

 
S166-p MNRQEFSsEEMtKSL
T170-p EFSsEEMtKSLETKS
S494-p LHSGEMEsEPKQRQS
Y653 LKSVDGSYTIRQAQL
Y703 SPELLALYCASSLVI
S706 LLALYCASSLVIPAI
S707 LALYCASSLVIPAIG
Y718 PAIGMIVYFARKANM
K736-ub YSLVEAQkSKV____
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