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Protein Page:
ANXA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ANXA1 a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Lipid binding protein; Calcium-binding protein
Cellular Component: extracellular space; cell surface; protein complex; basolateral plasma membrane; mitochondrial membrane; cytoplasm; plasma membrane; extracellular region; cornified envelope; nucleus; sarcolemma; cilium
Molecular Function: protein binding, bridging; protein binding; protein homodimerization activity; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; phospholipid binding; calcium ion binding; structural molecule activity; calcium-dependent protein binding; receptor binding
Biological Process: response to drug; response to peptide hormone stimulus; positive regulation of neutrophil apoptosis; gliogenesis; negative regulation of acute inflammatory response; alpha-beta T cell differentiation; positive regulation of vesicle fusion; arachidonic acid secretion; neutrophil homeostasis; signal transduction; endocrine pancreas development; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; estrous cycle phase; cell surface receptor linked signal transduction; insulin secretion; negative regulation of catalytic activity; peptide cross-linking; cell motility; inflammatory response; response to X-ray; negative regulation of apoptosis; positive regulation of prostaglandin biosynthetic process
Reference #:  P04083 (UniProtKB)
Alt. Names/Synonyms: Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANX1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; LPC1; p35; Phospholipase A2 inhibitory protein
Gene Symbols: ANXA1
Molecular weight: 38,714 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANXA1

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S27‑p
exocytosis, altered: S27‑p, S45‑p
intracellular localization: Y21‑p, S27‑p, S28‑p, S45‑p
molecular association, regulation: S5‑p
protein conformation: S5‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 4 S5-p ___MAMVsEFLKQAW
0 1 K9 AMVsEFLKQAWFIEN
5 177 Y21-p IENEEQEyVQTVkss
1 0 T24 EEQEyVQTVksskGG
0 5 K26-ub QEyVQTVksskGGPG
5 0 S27-p EyVQTVksskGGPGs
2 0 S28-p yVQTVksskGGPGsA
0 12 K29 VQTVkssKGGPGsAV
0 2 K29-ub VQTVksskGGPGsAV
1 9 S34-p sskGGPGsAVsPyPt
0 17 S37-p GGPGsAVsPyPtFNP
0 1 S37-ga GGPGsAVsPyPtFNP
0 204 Y39-p PGsAVsPyPtFNPsS
0 6 T41-p sAVsPyPtFNPsSDV
1 0 S45-p PyPtFNPsSDVAALH
0 2 K53-ac SDVAALHkAIMVkGV
0 3 K53-ub SDVAALHkAIMVkGV
0 7 K58-ub LHkAIMVkGVDEAtI
0 1 T64-p VkGVDEAtIIDILtk
0 1 T70-p AtIIDILtkRNNAQR
0 3 K71-ac tIIDILtkRNNAQRQ
0 2 K71-ub tIIDILtkRNNAQRQ
0 1 K81-ub NAQRQQIkAAyLQEt
0 14 Y84-p RQQIkAAyLQEtGkP
0 1 T88-p kAAyLQEtGkPLDEt
0 3 K90-ac AyLQEtGkPLDEtLk
0 1 K90-ub AyLQEtGkPLDEtLk
0 1 T95-p tGkPLDEtLkkALTG
0 66 K97-ac kPLDEtLkkALTGHL
0 1 K97-ub kPLDEtLkkALTGHL
0 1 K97-sc kPLDEtLkkALTGHL
0 2 K98-ac PLDEtLkkALTGHLE
0 1 K98-ub PLDEtLkkALTGHLE
0 4 K128-ub DELRAAMkGLGTDED
0 1 T136-p GLGTDEDtLIEILAs
0 1 S143-p tLIEILAsRTNKEIR
0 16 K161-ac RVYREELkRDLAkDI
0 1 K166-ac ELkRDLAkDItsDts
0 4 K166-ub ELkRDLAkDItsDts
0 1 K166-sc ELkRDLAkDItsDts
0 2 T169-p RDLAkDItsDtsGDF
0 5 S170-p DLAkDItsDtsGDFR
0 2 T172-p AkDItsDtsGDFRNA
0 5 S173-p kDItsDtsGDFRNAL
0 2 S182-p DFRNALLsLAkGDRs
0 1 K185-ac NALLsLAkGDRsEDF
0 2 K185-ub NALLsLAkGDRsEDF
0 1 K185-sc NALLsLAkGDRsEDF
0 1 S189-p sLAkGDRsEDFGVNE
0 543 Y207-p DSDARALyEAGERRk
0 1 K214-ub yEAGERRkGtDVNVF
2 2 T216-p AGERRkGtDVNVFNT
0 1 T226-p NVFNTILtTRSyPQL
0 1 Y230-p TILtTRSyPQLRRVF
0 4 K239-ac QLRRVFQkyTKYSKH
0 1 Y240-p LRRVFQkyTKYSKHD
0 1 K250-ac YSKHDMNkVLDLELk
0 1 K250-ub YSKHDMNkVLDLELk
0 7 K257-ub kVLDLELkGDIEKCL
1 0 K257 kVLDLELKGDIEKCL
0 1 T265 GDIEKCLTAIVKCAT
0 1 A266 DIEKCLTAIVKCATS
0 1 T272 TAIVKCATSkPAFFA
0 5 K274-ub IVKCATSkPAFFAEk
0 3 K281-ac kPAFFAEkLHQAMkG
0 2 K281-ub kPAFFAEkLHQAMkG
0 4 K287-ub EkLHQAMkGVGTRHK
0 33 K312-ac EIDMNDIkAFYQKMY
0 1 K312-ub EIDMNDIkAFYQKMY
0 5 K332-ub QAILDETkGDyEkIL
0 1 Y335-p LDETkGDyEkILVAL
0 1 K337-ub ETkGDyEkILVALCG
  mouse

 
S5-p ___MAMVsEFLkQAR
K9-ac AMVsEFLkQARFLEN
Y21-p LENQEQEyVQAVksY
A24 QEQEyVQAVksYkGG
K26-ub QEyVQAVksYkGGPG
S27-p EyVQAVksYkGGPGs
Y28 yVQAVksYkGGPGsA
K29-ac VQAVksYkGGPGsAV
K29 VQAVksYKGGPGsAV
S34-p sYkGGPGsAVsPYPS
S37-p GGPGsAVsPYPSFNV
S37 GGPGsAVSPYPSFNV
Y39 PGsAVsPYPSFNVSS
S41 sAVsPYPSFNVSSDV
S45 PYPSFNVSSDVAALH
K53 SDVAALHKAIMVKGV
K53 SDVAALHKAIMVKGV
K58 LHKAIMVKGVDEATI
T64 VKGVDEATIIDILTk
T70 ATIIDILTkRTNAQR
K71-ac TIIDILTkRTNAQRQ
K71 TIIDILTKRTNAQRQ
K81 NAQRQQIKAAYLQEN
Y84 RQQIKAAYLQENGKP
N88 KAAYLQENGKPLDEV
K90 AYLQENGKPLDEVLR
K90 AYLQENGKPLDEVLR
V95 NGKPLDEVLRKALTG
R97 KPLDEVLRKALTGHL
R97 KPLDEVLRKALTGHL
R97 KPLDEVLRKALTGHL
K98 PLDEVLRKALTGHLE
K98 PLDEVLRKALTGHLE
K128-ub DELRGAMkGLGTDED
T136 GLGTDEDTLIEILTT
T143 TLIEILTTRSNEQIR
K161-ac RVYREELkRDLAkDI
K166 ELkRDLAKDITSDTs
K166-ub ELkRDLAkDITSDTs
K166 ELkRDLAKDITSDTs
T169 RDLAkDITSDTsGDF
S170 DLAkDITSDTsGDFR
T172 AkDITSDTsGDFRKA
S173-p kDITSDTsGDFRKAL
A182 DFRKALLALAKGDRC
K185 KALLALAKGDRCQDL
K185 KALLALAKGDRCQDL
K185 KALLALAKGDRCQDL
C189 ALAKGDRCQDLSVNQ
Y207-p DTDARALyEAGERRK
K214 yEAGERRKGTDVNVF
T216 AGERRKGTDVNVFTT
T226 NVFTTILTSRSFPHL
F230 TILTSRSFPHLRRVF
N239 HLRRVFQNYGKYSQH
Y240 LRRVFQNYGKYSQHD
K250 YSQHDMNKALDLELk
K250 YSQHDMNKALDLELk
K257 KALDLELKGDIEKCL
K257-sm KALDLELkGDIEKCL
T265 GDIEKCLTTIVKCAt
T266 DIEKCLTTIVKCAtS
T272-p TTIVKCAtSTPAFFA
T274 IVKCAtSTPAFFAEK
K281 TPAFFAEKLYEAMKG
K281 TPAFFAEKLYEAMKG
K287 EKLYEAMKGAGTRHK
K312-ac EIDMNEIkVFYQKKY
K312 EIDMNEIKVFYQKKY
K332 QAILDETKGDYEKIL
Y335 LDETKGDYEKILVAL
K337 ETKGDYEKILVALCG
  rat

 
S5-p ___MAMVsEFLKQAC
K9 AMVsEFLKQACYIEK
Y21-p IEKQEQEyVQAVKSY
A24 QEQEyVQAVKSYKGG
K26 QEyVQAVKSYKGGPG
S27 EyVQAVKSYKGGPGS
Y28 yVQAVKSYKGGPGSA
K29 VQAVKSYKGGPGSAV
K29 VQAVKSYKGGPGSAV
S34 SYKGGPGSAVSPYPS
S37 GGPGSAVSPYPSFNP
S37 GGPGSAVSPYPSFNP
Y39 PGSAVSPYPSFNPSS
S41 SAVSPYPSFNPSSDV
S45 PYPSFNPSSDVAALH
K53 SDVAALHKAIMVKGV
K53 SDVAALHKAIMVKGV
K58 LHKAIMVKGVDEATI
T64 VKGVDEATIIDILTk
T70 ATIIDILTkRTNAQR
K71-ac TIIDILTkRTNAQRQ
K71 TIIDILTKRTNAQRQ
K81 NAQRQQIKAAYLQET
Y84 RQQIKAAYLQETGkP
T88 KAAYLQETGkPLDET
K90-ac AYLQETGkPLDETLk
K90 AYLQETGKPLDETLk
T95 TGkPLDETLkKALTG
K97-ac kPLDETLkKALTGHL
K97 kPLDETLKKALTGHL
K97 kPLDETLKKALTGHL
K98 PLDETLkKALTGHLE
K98 PLDETLkKALTGHLE
K128 DELRAAMKGLGTDED
T136 GLGTDEDTLIEILTT
T143 TLIEILTTRSNQQIR
K161-ac RVYREELkRDLAkDI
K166-ac ELkRDLAkDITSDTS
K166 ELkRDLAKDITSDTS
K166 ELkRDLAKDITSDTS
T169 RDLAkDITSDTSGDF
S170 DLAkDITSDTSGDFR
T172 AkDITSDTSGDFRNA
S173 kDITSDTSGDFRNAL
A182 DFRNALLALAkGDRC
K185-ac NALLALAkGDRCEDM
K185 NALLALAKGDRCEDM
K185 NALLALAKGDRCEDM
C189 ALAkGDRCEDMSVNQ
Y207 DTDARALYEAGERRK
K214 YEAGERRKGtDVNVF
T216-p AGERRKGtDVNVFNT
T226 NVFNTILTTRSYPHL
Y230 TILTTRSYPHLRKVF
N239 HLRKVFQNYRKYSQH
Y240 LRKVFQNYRKYSQHD
K250 YSQHDMNKALDLELK
K250 YSQHDMNKALDLELK
K257 KALDLELKGDIEKCL
K257 KALDLELKGDIEKCL
T265-p GDIEKCLttIVKCAT
T266-p DIEKCLttIVKCATS
T272 ttIVKCATSTPAFFA
T274 IVKCATSTPAFFAEK
K281 TPAFFAEKLYEAMKG
K281 TPAFFAEKLYEAMKG
K287 EKLYEAMKGAGTRHK
K312-ac EIDMNEIkVFYQKKY
K312 EIDMNEIKVFYQKKY
K332 QAILDETKGDYEKIL
Y335 LDETKGDYEKILVAL
K337 ETKGDYEKILVALCG
  cow

 
S5-p ___MAMVsEFLKQAW
K9 AMVsEFLKQAWFIEN
Y21 IENEEQEYIKtVKGs
T24-p EEQEYIKtVKGsKGG
K26 QEYIKtVKGsKGGPG
G27 EYIKtVKGsKGGPGS
S28-p YIKtVKGsKGGPGSA
K29 IKtVKGsKGGPGSAV
K29 IKtVKGsKGGPGSAV
S34 GsKGGPGSAVSPYPT
S37 GGPGSAVSPYPTFNP
S37 GGPGSAVSPYPTFNP
Y39 PGSAVSPYPTFNPSS
T41 SAVSPYPTFNPSSDV
S45 PYPTFNPSSDVEALH
K53 SDVEALHKAITVKGV
K53 SDVEALHKAITVKGV
K58 LHKAITVKGVDEATI
T64 VKGVDEATIIEILTK
T70 ATIIEILTKRNNAQR
K71 TIIEILTKRNNAQRQ
K71 TIIEILTKRNNAQRQ
K81 NAQRQQIKAAYLQEK
Y84 RQQIKAAYLQEKGKP
K88 KAAYLQEKGKPLDEV
K90 AYLQEKGKPLDEVLK
K90 AYLQEKGKPLDEVLK
V95 KGKPLDEVLKKALLG
K97 KPLDEVLKKALLGHL
K97 KPLDEVLKKALLGHL
K97 KPLDEVLKKALLGHL
K98 PLDEVLKKALLGHLE
K98 PLDEVLKKALLGHLE
K128 EELRAAMKGLGTDED
T136 GLGTDEDTLNEILAS
S143 TLNEILASRTNREIR
K161 RVYREELKRDLAKDI
K166 ELKRDLAKDIASDTS
K166 ELKRDLAKDIASDTS
K166 ELKRDLAKDIASDTS
A169 RDLAKDIASDTSGDY
S170 DLAKDIASDTSGDYE
T172 AKDIASDTSGDYEKA
S173 KDIASDTSGDYEKAL
S182 DYEKALLSLAKGDRS
K185 KALLSLAKGDRSEEL
K185 KALLSLAKGDRSEEL
K185 KALLSLAKGDRSEEL
S189 SLAKGDRSEELAVND
Y207 DSDARALYEAGERRK
K214 YEAGERRKGTDVNVF
T216 AGERRKGTDVNVFIT
T226 NVFITILTTRSYPHL
Y230 TILTTRSYPHLRRVF
K239 HLRRVFQKYSKYSKH
Y240 LRRVFQKYSKYSKHD
K250 YSKHDMNKVLDLELK
K250 YSKHDMNKVLDLELK
K257 KVLDLELKGDIEKCL
K257 KVLDLELKGDIEKCL
T265 GDIEKCLTVIVKCAT
V266 DIEKCLTVIVKCATS
T272 TVIVKCATSQPMFFA
Q274 IVKCATSQPMFFAEK
K281 QPMFFAEKLHQAMKG
K281 QPMFFAEKLHQAMKG
K287 EKLHQAMKGIGTRHK
K312 EIDMNDIKACYQKLY
K312 EIDMNDIKACYQKLY
K332 QAILDETKGDYEKIL
Y335 LDETKGDYEKILVAL
K337 ETKGDYEKILVALCG
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