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Protein Page:
FLNC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FLNC Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Defects in FLNC are the cause of myopathy myofibrillar type 5 (MFM5). A neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations, and clinical features of a limb-girdle myopathy. Defects in FLNC are the cause of myopathy distal type 4 (MPD4). MPD4 is a slowly progressive muscular disorder characterized by distal muscle weakness and atrophy affecting the upper and lower limbs. Onset occurs around the third to fourth decades of life, and patients remain ambulatory even after long disease duration. Muscle biopsy shows non-specific changes with no evidence of rods, necrosis, or inflammation. Belongs to the filamin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q32-q35
Cellular Component: cytoskeleton; costamere; cytoplasm; plasma membrane; Z disc; sarcoplasm; cytosol; sarcolemma
Molecular Function: protein binding; cytoskeletal protein binding; ankyrin binding; actin binding
Biological Process: muscle fiber development
Reference #:  Q14315 (UniProtKB)
Alt. Names/Synonyms: ABP-280; ABP-280-like protein; ABP-L; ABP-L, gamma filamin; ABP280A; ABPA; ABPL; actin binding protein 280; Actin-binding-like protein; filamin 2; filamin C, gamma; Filamin-2; Filamin-C; FLJ10186; FLN-C; FLN2; FLNC; Gamma-filamin
Gene Symbols: FLNC
Molecular weight: 291,022 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLNC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MMNNsGYSDAGL
0 4 K35-ac LAEDAPWkkIQQNTF
0 4 K36-ub AEDAPWkkIQQNTFT
0 3 K80-ub LLEVLSQkRMYRKFH
0 1 K162-ac DARKQTPkQRLLGWI
0 1 K189-ub NRDWQDGkALGALVD
0 1 S379-p LGDANKVsARGPGLE
0 3 Y397-p NVANKPTyFDIyTAG
0 1 Y401-p KPTyFDIyTAGAGTG
0 1 T501-p VADFKVFtKGAGSGE
0 1 Y545-p YPVVPGKyVVTITWG
0 2 K734-ac RCSYVPTkPIKHTII
0 1 Y770-p HPERVKVyGPGVEkT
0 1 K776-ac VyGPGVEkTGLKANE
0 1 K776 VyGPGVEKTGLKANE
0 1 K871 SHDASKVKAEGPGLN
0 1 K886-m1 RTGVEVGkPTHFTVL
0 1 S954 GGDPVPKSPFVVNVA
0 1 K968-ac APPLDLSkIKVQGLN
0 1 R1002 GQGQLDVRMTsPSRR
0 1 S1005-p QLDVRMTsPSRRPIP
0 1 K1014-ac SRRPIPCkLEPGGGA
0 1 K1014 SRRPIPCKLEPGGGA
0 1 S1050 DGHPVPGSPFAVEGV
0 25 Y1068-p DPSKVCAyGPGLKGG
0 1 S1161-p DPSKVRAsGPGLERG
0 1 S1296 TARVLNPSGAKtDty
0 1 K1299 VLNPSGAKtDtyVTD
0 1 T1300-p LNPSGAKtDtyVTDN
0 1 T1302-p PSGAKtDtyVTDNGD
0 1 Y1303-p SGAKtDtyVTDNGDG
0 1 Y1312-p TDNGDGTyRVQYTAY
0 1 K1337-ac YDEVAVPksPFRVGV
0 1 S1338-p DEVAVPksPFRVGVT
0 1 T1351 VTEGCDPTRVRAFGP
0 1 K1367 LEGGLVNKANRFTVE
0 5 S1527-p ADQEVPRsPFKIKVL
0 1 K1530 EVPRsPFKIKVLPAH
0 1 K1532 PRsPFKIKVLPAHDA
0 1 Y1602-p DGTYTVSyLPDMSGR
0 1 S1624 GGDEIPYSPFRIHAL
0 1 S1728 GGEHIPNSPFHVLAC
0 1 T1809-p VRMPSGKtARPNITD
0 1 T1821-p ITDNKDGtItVRYAP
0 1 T1823-p DNKDGtItVRYAPTE
0 2 K1831-ac VRYAPTEkGLHQMGI
0 1 K1839 GLHQMGIKYDGNHIP
0 1 S1848 DGNHIPGSPLQFYVD
0 1 K1935 IIVRFDDKHIPGSPF
0 1 S1972-p VSLKITEsDLSQLtA
0 1 T1978-p EsDLSQLtAsIRAPS
0 1 S1980-p DLSQLtAsIRAPSGN
0 1 K1994-ac NEEPCLLkRLPNRHI
0 2 K1994-ub NEEPCLLkRLPNRHI
0 1 T2006-p RHIGISFtPKEVGEH
0 1 S2016-p EVGEHVVsVRKSGKH
0 1 S2042-p PSEIGDAsKVRVWGK
0 2 S2122-p ADKHVPGsPFtVKVT
0 1 T2125-p HVPGsPFtVKVTGEG
0 2 S2146-p TRRRQAPsIATIGST
0 2 T2179-p ERLTRTFtRSSHTYT
2 176 S2233-p LGRERLGsFGsItRQ
0 14 S2236-p ERLGsFGsItRQQEG
0 6 T2238-p LGsFGsItRQQEGEA
0 1 K2291 GPHTVAVKYRGQHVP
0 2 S2300-p RGQHVPGsPFQFTVG
1 3 T2412-p SDDARRLtVtsLQET
0 1 T2414-p DARRLtVtsLQETGL
0 1 S2415-p ARRLtVtsLQETGLK
0 1 T2446 VIDARVHTPSGAVEE
0 5 Y2455-p SGAVEECyVsELDSD
0 1 S2457-p AVEECyVsELDSDKH
0 1 S2490-p NGAHIPGsPFkIRVG
0 2 K2493-ac HIPGsPFkIRVGEQS
0 1 Y2577-p NYLIAIKyGGPQHIV
0 1 S2586-p GPQHIVGsPFKAKVT
0 3 S2598-p KVTGPRLsGGHSLHE
0 1 T2613-p TSTVLVEtVtKsSss
0 1 T2615-p TVLVEtVtKsSssRG
0 1 S2617-p LVEtVtKsSssRGss
0 1 S2619-p EtVtKsSssRGssys
0 3 S2620-p tVtKsSssRGssyss
0 1 S2623-p KsSssRGssyssIPK
0 3 S2624-p sSssRGssyssIPKF
0 2 Y2625-p SssRGssyssIPKFs
0 2 S2626-p ssRGssyssIPKFsS
0 3 S2627-p sRGssyssIPKFsSD
0 1 S2632-p yssIPKFsSDASKVV
0 214 Y2683-p KTPCEEVyVKHMGNR
0 1 K2699-sc YNVTYTVkEKGDYIL
0 5 S2714-p IVKWGDEsVPGsPFK
0 3 S2718-p GDEsVPGsPFKVKVP
  mouse

 
S5 ___MMNNSNYSDASG
K36-ac LAEDAPWkkIQQNTF
K37-ub AEDAPWkkIQQNTFT
K81 LLEVLSQKRMYRKFH
K163 DARKQTPKQRLLGWI
K190 NRDWQDGKALGALVD
S380 LGDANKVSARGPGLE
Y398 NVANKPTYFDIYTAG
Y402 KPTYFDIYTAGAGTG
T502 VADFKVFTKGAGSGE
Y546 YPVVPGKYVVTITWG
K735-ac RCSYVPTkPIKHTII
Y771 HPERVKVYGPGVEkT
K777 VYGPGVEKTGLKANE
K777-ub VYGPGVEkTGLKANE
K872-ub SHDASKVkAEGPGLS
K887 RTGVEVGKPTHFTVL
S955-p GGDPVPKsPFVVNVA
K969 APPLDLSKVKVQGLN
R1003-m1 GQGQLDVrMTSPSRR
S1006 QLDVrMTSPSRRPIP
K1015 SRRPIPCKLEPGGGA
K1015-ub SRRPIPCkLEPGGGA
S1051-p DGHPVPGsPFAVEGV
Y1069-p DPSKVCAyGPGLKGG
S1162 DPSKVRASGPGLERG
S1297-p TARVLNPsGAkTDTY
K1300-ub VLNPsGAkTDTYVTD
T1301 LNPsGAkTDTYVTDN
T1303 PsGAkTDTYVTDNGD
Y1304 sGAkTDTYVTDNGDG
Y1313 TDNGDGTYRVQYTAY
K1338 YDEVAVPKSPFRVGV
S1339 DEVAVPKSPFRVGVT
T1352-p VTEGCDPtRVRAFGP
K1368-ub LEGGLVNkANRFTVE
S1528-p ADQEVPRsPFkIkVL
K1531-ub EVPRsPFkIkVLPSH
K1533-ub PRsPFkIkVLPSHDA
Y1603 DGTYTVSYLPDMSGR
S1625-p GGDEIPYsPFRIHAL
S1729-p GGEHIPNsPFHVLAC
T1810 VRMPSGKTARPNITD
T1822 ITDNKDGTITVRYAP
T1824 DNKDGTITVRYAPTE
K1832-ac VRYAPTEkGLHQMGI
K1840-ac GLHQMGIkYDGNHIP
S1849-p DGNHIPGsPLQFYVD
K1936-ub IIVRFDDkHIPGSPF
G1973 VSLKITEGDLSQLTA
T1979 EGDLSQLTASIRAPS
S1981 DLSQLTASIRAPSGN
K1995 NEEPCLLKRLPNRHI
K1995-ub NEEPCLLkRLPNRHI
T2007-p RHIGISFtPKEVGEH
S2017 EVGEHVVSVRKSGKH
S2043 PSEIGDASKVRVWGK
S2123-p ADKHVPGsPFTVKVT
T2126 HVPGsPFTVKVTGEG
S2147-p TRRRQAPsIATIGST
T2180-p ERLTRTFtRSSHTYT
S2234-p LGRERLGsFGsItRQ
S2237-p ERLGsFGsItRQQEG
T2239-p LGsFGsItRQQEGEA
K2292-ub GPHTVTVkYRGQHVP
S2301-p RGQHVPGsPFQFTVG
T2413 SDDARRLTVTSLQET
T2415 DARRLTVTSLQETGL
S2416 ARRLTVTSLQETGLK
T2447-p VIDARVHtPSGAVEE
Y2456 SGAVEECYVSELDSD
S2458 AVEECYVSELDSDKH
S2491-p NGAHIPGsPFKIRVG
K2494 HIPGsPFKIRVGEQS
Y2578 NYLIAIKYGGPQHIV
S2587 GPQHIVGSPFKAKVT
S2599-p KVTGPRLsGGHSLHE
T2614 TSTVLVETVTKSSSS
T2616 TVLVETVTKSSSSRG
S2618 LVETVTKSSSSRGAs
S2620 ETVTKSSSSRGAsYS
S2621 TVTKSSSSRGAsYSS
A2624 KSSSSRGAsYSSIPK
S2625-p SSSSRGAsYSSIPKF
Y2626 SSSRGAsYSSIPKFS
S2627 SSRGAsYSSIPKFSS
S2628 SRGAsYSSIPKFSSD
S2633 YSSIPKFSSDASKVV
Y2684-p KTPCEEVyVKHMGNR
K2700 YNVTYTVKEKGDYIL
S2715 IVKWGDESVPGSPFK
S2719 GDESVPGSPFKVNVP
  rat

 
S5 ___MMNNSNYSDASG
K36-ac LAEDAPWkKIQQNTF
K37 AEDAPWkKIQQNTFT
K81 LLEVLSQKRMYRKFH
K163 DARKQTPKQRLLGWI
K190 NRDWQDGKALGALVD
S380 LGDANKVSARGPGLE
Y398 NVANKPTYFDIYTAG
Y402 KPTYFDIYTAGAGTG
T502 VADFKVFTKGAGSGE
Y546 YPVIPGKYVVTITWG
K735-ac RCSYVPTkPIKHTVI
Y771 HPERVKVYGPGVEKT
K777 VYGPGVEKTGLKANE
K777 VYGPGVEKTGLKANE
K872 SHDASKVKAEGPGLS
K887 RTGVEVGKPTHFTVL
S955 GGDPVPKSPFVVNVA
K969 APPLDLSKVKVQGLN
R1003 GQGQLDVRMTSPSRR
S1006 QLDVRMTSPSRRPIP
K1015-ac SRRPIPCkLEPGSGA
K1015 SRRPIPCKLEPGSGA
S1051 DGHPVPGSPFAVEGV
Y1069 DPSKVCAYGPGLKGG
S1162 DPSKVRASGPGLERG
S1297 TARVLNPSGAKTDTY
K1300 VLNPSGAKTDTYVTD
T1301 LNPSGAKTDTYVTDN
T1303 PSGAKTDTYVTDNGD
Y1304 SGAKTDTYVTDNGDG
Y1313 TDNGDGTYRVQYTAY
K1338 YDEVAVPKsPFRVGV
S1339-p DEVAVPKsPFRVGVT
T1352 VTEGCDPTRVRAFGP
K1368 LEGGLVNKANRFTVE
S1528 ADQEVPRSPFKIKVL
K1531 EVPRSPFKIKVLPAH
K1533 PRSPFKIKVLPAHDA
Y1603 DGTYTVSYLPDMSGR
S1625 GGDEIPYSPFRIHAL
S1729 GGEHIPNSPFHVLAC
T1810 VRMPSGKTARPNITD
T1822 ITDNKDGTITVRYAP
T1824 DNKDGTITVRYAPTE
K1832 VRYAPTEKGLHQMGI
K1840 GLHQMGIKYDGNHIP
S1849 DGNHIPGSPLQFYVD
K1936 IIVRFDDKHIPGSPF
G1973 VSLKITEGDLSQLTA
T1979 EGDLSQLTASIRAPS
S1981 DLSQLTASIRAPSGN
K1995 NEEPCLLKRLPNRHI
K1995 NEEPCLLKRLPNRHI
T2007 RHIGISFTPKEVGEH
S2017 EVGEHVVSVRKSGKH
S2043 PSEIGDASKVRVWGK
S2123 ADKHVPGSPFTVKVT
T2126 HVPGSPFTVKVTGEG
S2147 TRRRQAPSIATIGST
T2180 ERLTRTFTRSSHTYT
S2234-p LGRERLGsFGsITRQ
S2237-p ERLGsFGsITRQQEG
T2239 LGsFGsITRQQEGEA
K2292 GPHTVAVKYRGQHVP
S2301 RGQHVPGSPFQFTVG
T2413-p SDDARRLtVTSLQET
T2415 DARRLtVTSLQETGL
S2416 ARRLtVTSLQETGLK
T2447 VIDARVHTPSGAVEE
Y2456 SGAVEECYVSELDSD
S2458 AVEECYVSELDSDKH
S2491 NGAHIPGSPFKIRVG
K2494 HIPGSPFKIRVGEQS
Y2578 NYLIAIKYGGPQHIV
S2587 GPQHIVGSPFKAKVT
S2599 KVTGPRLSGGHSLHE
T2614 TSTVLVETVTKSSSS
T2616 TVLVETVTKSSSSRG
S2618 LVETVTKSSSSRGAs
S2620 ETVTKSSSSRGAsYS
S2621 TVTKSSSSRGAsYSS
A2624 KSSSSRGAsYSSIPK
S2625-p SSSSRGAsYSSIPKF
Y2626 SSSRGAsYSSIPKFS
S2627 SSRGAsYSSIPKFSS
S2628 SRGAsYSSIPKFSSD
S2633 YSSIPKFSSDASKVV
Y2684 KTPCEEVYVKHMGNR
K2700 YNVTYTVKEKGDYIL
S2715 IVKWGDESVPGSPFK
S2719 GDESVPGSPFKVNVP
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