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Protein Page:
FGFR4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR4 a tyrosine-kinase receptor that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of the MAP kinase and AKT signaling pathways. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Two isoforms of the human protein are formed by alternative splicing. This description may include information from UniProtKB.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; FGFR family
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: endoplasmic reticulum; integral to plasma membrane; cytoplasm; plasma membrane; nucleolus; extracellular region; intercellular junction; nucleus; endosome
Molecular Function: heparin binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; cell migration; regulation of lipid metabolic process; peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of proteolysis; protein amino acid autophosphorylation; positive regulation of metalloenzyme activity; glucose homeostasis; induction of an organ; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; phosphate ion homeostasis
Reference #:  P22455 (UniProtKB)
Alt. Names/Synonyms: CD334; FGFR-4; FGFR4; Fibroblast growth factor receptor 4; JTK2; MGC20292; TKF; tyrosine kinase related to fibroblast growth factor receptor
Gene Symbols: FGFR4
Molecular weight: 87,954 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGFR4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 T167-p HAVPAGNtVKFRCPA
0 1 T368-p AAPEARYtDIILYAS
0 1 K408 RPPATVQKLsRFPLA
0 1 S410-p PATVQKLsRFPLARQ
0 8 S419-p FPLARQFsLESGSSG
0 1 K427 LESGSSGKSSSSLVR
0 13 S439-p LVRGVRLsssGPALL
0 12 S440-p VRGVRLsssGPALLA
0 3 S441-p RGVRLsssGPALLAG
0 2 K471 RDRLVLGKPLGEGCF
0 1 S519-p KDLADLVsEMEVMKL
0 5 S573-p RPPGPDLsPDGPRSS
0 1 K627-ub VTEDNVMkIADFGLA
0 55 Y642-p RGVHHIDyyKKTSNG
0 34 Y643-p GVHHIDyyKKTSNGR
1 8 Y754-p LLAVSEEyLDLRLTF
  FGFR4 iso3  
K223-ub IGTVTPSkVSRSPRT
T282 HAVPAGNTVKFRCPA
T600 AAPEARYTDIILYAS
K640 RPPATVQKLSRFPLA
S642 PATVQKLSRFPLARQ
S651-p FPLARQFsLESGSSG
K659 LESGSSGKSSSSLVR
S671 LVRGVRLSSSGPALL
S672 VRGVRLSSSGPALLA
S673 RGVRLSSSGPALLAG
K703 RDRLVLGKPLGEGCF
S751 KDLADLVSEMEVMKL
S805 RPPGPDLSPDGPRSS
K859 VTEDNVMKIADFGLA
Y874 RGVHHIDYYKKTSNG
Y875 GVHHIDYYKKTSNGR
Y986 LLAVSEEYLDLRLTF
  mouse

 
- gap
T164 HAVPAGNTVKFRCPA
T365 ATPEARYTDIILYVS
K405-ub RQPVTIQkLSRFPLA
S407 PVTIQkLSRFPLARQ
S416 FPLARQFSLESRSSG
K424-ub LESRSSGkSSLSLVR
S436 LVRGVRLSSSGPPLL
S437 VRGVRLSSSGPPLLT
S438 RGVRLSSSGPPLLTG
K468-ub RDRLVLGkPLGEGCF
S516 KDLADLVSEMEVMKL
S570 RPPGPDLSPDGPRSS
K624 VTEDDVMKIADFGLA
Y639-p RGVHHIDyyKKTSNG
Y640-p GVHHIDyyKKTSNGR
Y751-p LLAVSEEyLDLRLTF
  rat

 
- gap
T163 HAVPAGNTVKFRCPA
T366 ATSEARYTDIILYVS
K406 RQPVTVQKLSRFPLA
S408 PVTVQKLSRFPLARQ
S417-p FPLARQFsLESRSSG
K425 LESRSSGKSSLSLVR
S437 LVRGVRLSSSGPPLL
S438 VRGVRLSSSGPPLLT
S439 RGVRLSSSGPPLLTG
K469 RDRLVLGKPLGEGCF
S517 KDLADLISEMEMMKL
S571 RPPGPDLSPDGPRSS
K625 VTEDDVMKIADFGLA
Y640 RGVHHIDYYKKTSNG
Y641 GVHHIDYYKKTSNGR
Y752 LLAVSEEYLDLRLTF
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