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Protein Page:
FGFR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGFR2 a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with many craniosynostotic syndromes and bone malformations. Mutations cause syndromes with defects in facial and limb development, including Crouzon syndrome, Beare-Stevenson cutis gyrata syndrome, Pfeiffer syndrome, Apert syndrome, and Jackson-Weiss syndrome. Somatic mutations seen in gastric cancer. Amplified in gastric, breast and some B cell cancers, but deleted in glioblastoma Twenty splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; FGFR family
Cellular Component: Golgi apparatus; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; integral to membrane; extracellular region; excitatory synapse; cell cortex; extracellular matrix; membrane; cytoplasm; nucleolus; plasma membrane; nucleus
Molecular Function: heparin binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding
Biological Process: nerve growth factor receptor signaling pathway; mesodermal cell differentiation; embryonic pattern specification; post-embryonic development; embryonic organ morphogenesis; morphogenesis of embryonic epithelium; cell-cell signaling; embryonic digestive tract morphogenesis; positive regulation of mesenchymal cell proliferation; midbrain development; ventricular cardiac muscle morphogenesis; neuromuscular junction development; positive regulation of cardiac muscle cell proliferation; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; cell fate commitment; regulation of osteoblast differentiation; positive regulation of cell cycle; regulation of fibroblast growth factor receptor signaling pathway; embryonic cranial skeleton morphogenesis; neuroblast division in the ventricular zone; organ growth; organ morphogenesis; mesenchymal cell differentiation; positive regulation of cell division; negative regulation of mitosis; embryonic organ development; gland morphogenesis; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; peptidyl-tyrosine phosphorylation; branching morphogenesis of a nerve; apoptosis; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; pyramidal neuron development; negative regulation of transcription from RNA polymerase II promoter; orbitofrontal cortex development; bone mineralization; odontogenesis; regulation of osteoblast proliferation; positive regulation of MAPKKK cascade; epithelial cell differentiation; ureteric bud development; epidermis morphogenesis; positive regulation of cell proliferation; regulation of smooth muscle cell differentiation; lacrimal gland development; angiogenesis; otic vesicle formation; positive regulation of Wnt receptor signaling pathway; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hair follicle morphogenesis; in utero embryonic development; multicellular organism growth; synaptic vesicle transport; regulation of multicellular organism growth; limb bud formation; gut development; axonogenesis; skeletal morphogenesis; regulation of cell fate commitment; insulin receptor signaling pathway; epithelial to mesenchymal transition; innate immune response; reproductive structure development; lung development; regulation of smoothened signaling pathway
Reference #:  P21802 (UniProtKB)
Alt. Names/Synonyms: bacteria-expressed kinase; BEK; BEK fibroblast growth factor receptor; BFR-1; CD332; CEK3; CFD1; ECT1; FGF receptor; FGFR-2; FGFR2; Fibroblast growth factor receptor 2; FLJ98662; JWS; K-sam; Keratinocyte growth factor receptor; KGFR; KSAM; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; TK14; TK25
Gene Symbols: FGFR2
Molecular weight: 92,025 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGFR2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S782‑p
cell growth, altered: Y769‑p, S782‑p
enzymatic activity, induced: Y769‑p
molecular association, regulation: Y769‑p, S782‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 S347-p YTCLAGNsIGISFHS
0 1 S437-p VSAESSSsMNsNtPL
0 1 S440-p ESSSsMNsNtPLVRI
0 1 T442-p SSsMNsNtPLVRItt
0 11 T448-p NtPLVRIttRLsstA
0 6 T449-p tPLVRIttRLsstAD
0 17 S452-p VRIttRLsstADtPM
0 15 S453-p RIttRLsstADtPML
0 15 T454-p IttRLsstADtPMLA
0 2 T457-p RLsstADtPMLAGVS
0 5 Y466-p MLAGVSEyELPEDPK
0 1 K539-ac VSEMEMMkMIGKHKN
0 13 Y586-p RRPPGMEysyDINRV
0 3 S587-p RPPGMEysyDINRVP
0 8 Y588-p PPGMEysyDINRVPE
0 1 S605 MTFKDLVSCTyQLAR
0 6 Y608-p KDLVSCTyQLARGME
0 2 Y616-p QLARGMEyLASQKCI
0 70 Y656-p RDINNIDyyKKTTNG
0 40 Y657-p DINNIDyyKKTTNGR
0 2 Y733-p ANCTNELyMMMRDCW
0 2 K751-ub PSQRPTFkQLVEDLD
4 0 Y769-p TLTTNEEyLDLSQPL
0 1 S780-p SQPLEQYsPsYPDTR
2 0 S782-p PLEQYsPsYPDTRss
0 1 S788-p PsYPDTRssCssGDD
0 1 S789-p sYPDTRssCssGDDS
0 1 S791-p PDTRssCssGDDSVF
0 1 S792-p DTRssCssGDDSVFS
0 1 Y805-p FSPDPMPyEPCLPQy
0 1 Y812-p yEPCLPQyPHINGSV
  mouse

► Hide Isoforms
 
- gap
S347 YTCLAGNSIGISFHS
S437 VSAESSSSMNSNTPL
S440 ESSSSMNSNTPLVRI
T442 SSSMNSNTPLVRItT
T448-p NTPLVRItTRLSSTA
T449 TPLVRItTRLSSTAD
S452 VRItTRLSSTADTPM
S453 RItTRLSSTADTPML
T454 ItTRLSSTADTPMLA
T457 RLSSTADTPMLAGVS
Y466 MLAGVSEYELPEDPK
K539 VSEMEMMKMIGKHKN
Y586 RRPPGMEYSYDINRV
S587 RPPGMEYSYDINRVP
Y588 PPGMEYSYDINRVPE
S605 MTFKDLVSCTYQLAR
Y608 KDLVSCTYQLARGME
Y616 QLARGMEYLASQKCI
Y656-p RDINNIDyyKKTTNG
Y657-p DINNIDyyKKTTNGR
Y733 TNCTNELYMMMRDCW
K751 PSQRPTFKQLVEDLD
Y769 TLTTNEEYLDLTQPL
S780 TQPLEQYSPSYPDTS
S782 PLEQYSPSYPDTSSS
S788 PSYPDTSSSCSSGDD
S789 SYPDTSSSCSSGDDS
S791 PDTSSSCSSGDDSVF
S792 DTSSSCSSGDDSVFS
Y805 FSPDPMPYEPCLPQY
Y812 YEPCLPQYPHINGSV
  FGFR2 iso2  
S228-p GEYICKVsNYIGQAN
Y230 YICKVsNYIGQANQS
S323 VSAESSSSMNSNTPL
S326 ESSSSMNSNTPLVRI
T328 SSSMNSNTPLVRITT
T334 NTPLVRITTRLSSTA
T335 TPLVRITTRLSSTAD
S338 VRITTRLSSTADTPM
S339 RITTRLSSTADTPML
T340 ITTRLSSTADTPMLA
T343 RLSSTADTPMLAGVS
Y352 MLAGVSEYELPEDPK
K425 VSEMEMMKMIGKHKN
Y472 RRPPGMEYSYDINRV
S473 RPPGMEYSYDINRVP
Y474 PPGMEYSYDINRVPE
S491 MTFKDLVSCTYQLAR
Y494 KDLVSCTYQLARGME
Y502 QLARGMEYLASQKCI
Y542 RDINNIDYYKKTTNG
Y543 DINNIDYYKKTTNGR
Y619 TNCTNELYMMMRDCW
K637 PSQRPTFKQLVEDLD
Y655 TLTTNEEYLDLTQPL
S666 TQPLEQYSPSYPDTS
S668 PLEQYSPSYPDTSSS
S674 PSYPDTSSSCSSGDD
S675 SYPDTSSSCSSGDDS
S677 PDTSSSCSSGDDSVF
S678 DTSSSCSSGDDSVFS
Y691 FSPDPMPYEPCLPQY
Y698 YEPCLPQYPHINGSV
  rat

 
S362 GEYICKVSNYIGQAN
Y364 YICKVSNYIGQANQS
S457 VSAESSSSMNSNTPL
S460 ESSSSMNSNTPLVRI
T462 SSSMNSNTPLVRITT
T468 NTPLVRITTRLSSTA
T469 TPLVRITTRLSSTAD
S472 VRITTRLSSTADTPM
S473 RITTRLSSTADTPML
T474 ITTRLSSTADTPMLA
T477 RLSSTADTPMLAGVS
Y486 MLAGVSEYELPEDPK
K559 VSEMEMMKMIGKHKN
Y606-p RRPPGMEySYDINRV
S607 RPPGMEySYDINRVP
Y608 PPGMEySYDINRVPE
S625-p MTFKDLVsCTYQLAR
Y628 KDLVsCTYQLARGME
Y636 QLARGMEYLASQKCI
Y676-p RDINNIDyyKKTTNG
Y677-p DINNIDyyKKTTNGR
Y753 TNCTNELYMMMRDCW
K771 PSQRPTFKQLVEDLD
Y789-p TLTTNEEyLDLTQPL
S800 TQPLEQYSPSYPDTR
S802 PLEQYSPSYPDTRSS
S808 PSYPDTRSSCSSGDD
S809 SYPDTRSSCSSGDDS
S811 PDTRSSCSSGDDSVF
S812 DTRSSCSSGDDSVFS
Y825 FSPDPMPYDPCLPQY
Y832 YDPCLPQYPHINGSV
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