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Protein Page:
ALK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALK2 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 2q23-q24
Cellular Component: integral to plasma membrane; apical part of cell; activin receptor complex
Molecular Function: protein homodimerization activity; peptide hormone binding; metal ion binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; positive regulation of osteoblast differentiation; negative regulation of activin receptor signaling pathway; mesoderm formation; regulation of skeletal muscle development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; regulation of ossification; determination of left/right symmetry; urogenital system development; acute inflammatory response; G1/S transition of mitotic cell cycle
Reference #:  Q04771 (UniProtKB)
Alt. Names/Synonyms: activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR-I; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK-2; ALK2; FOP; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSRI
Gene Symbols: ACVR1
Molecular weight: 57,153 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ALK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T203-p LPFLVQRtVARQITL
0 2 S226-p YGEVWRGsWQGENVA
0 1 K446 PSFEDMRKVVCVDQQ
0 1 K497 RIKKTLTKIDNsLDK
0 2 S501-p TLTKIDNsLDKLKTD
0 1 K504 KIDNsLDKLKTDC__
  mouse

 
T203 LPFLVQRTVARQITL
S226 YGEVWRGSWQGENVA
K446-ub PSFEDMRkVVCVDQQ
K497-ub RIKKTLTkIDNSLDk
S501 TLTkIDNSLDkLKTD
K504-ub kIDNSLDkLKTDC__
  rat

 
T203 LPFLVQRTVARQITL
S226 YGEVWRGSWQGENVA
K446 PSFEDMRKVVCVDQQ
K497 RIKKTLTKIDNSLDK
S501 TLTKIDNSLDKLKTD
K504 KIDNSLDKLKTDC__
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