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CALCOCO2 (human)

Overview CALCOCO2 May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4. Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. Note: This description may include information from UniProtKB. Protein type: Calcium-binding protein Cellular Component: Golgi apparatus; cytoskeleton; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus Molecular Function: protein binding; protein homodimerization activity Biological Process: viral reproduction Reference #:  Q13137 (UniProtKB) Alt. Names/Synonyms: Antigen nuclear dot 52 kDa protein; CACO2; calcium binding and coiled-coil domain 2; Calcium-binding and coiled-coil domain-containing protein 2; CALCOCO2; MGC17318; NDP52; Nuclear domain 10 protein 52; Nuclear domain 10 protein NDP52; Nuclear dot protein 52 Gene Symbols: CALCOCO2 Molecular weight: 52,254 Da Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CALCOCO2 3VVV - A=21-141 (human) 3VVW - A=21-141 (human) 4GXL - B=368-381 (human) 4HAN - A/B=184-317 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3VVV 3VVW 4GXL 4HAN  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K87-u	DLNNKSAkQQEVQFK
0	1		Y96-p	QEVQFKAyYLPKDDE
0	1		Y104-p	YLPKDDEyyQFCYVD
0	1		Y105-p	LPKDDEyyQFCYVDE
0	9		Y204-p	KVKEQKDyWETELLQ
0	1		K242-u	AQLSTQEkEMEKLVQ
0	5		K281-u	EQRKDQKkLEQTVEQ
0	3		K299-u	NETTAMKkQQELMDE
0	9		K312-u	DENFDLSkRLSENEI
0	28		K339-u	EGENDLLkRENSRLL
0	1		S347-p	RENSRLLsYMGLDFN
0	9		S355-p	YMGLDFNsLPyQVPT
0	5		Y358-p	LDFNsLPyQVPTSDE
0	2		Y376-p	RQNPGLAyGNPySGI
0	2		Y380-p	GLAyGNPySGIQESS
0	36		K395-u	SPSPLSIkkCPICKA
0	4		K396-u	PSPLSIkkCPICKAD

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