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calpain 1 (human)

Overview calpain 1 Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. Note: This description may include information from UniProtKB. Protein type: EC 3.4.22.52; Motility/polarity/chemotaxis; Protease Cellular Component: cytoplasm; plasma membrane Molecular Function: protein binding; cytoskeletal protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: protein autoprocessing; receptor catabolic process; positive regulation of cell proliferation; proteolysis Reference #:  P07384 (UniProtKB) Alt. Names/Synonyms: Calcium-activated neutral proteinase 1; calpain 1, (mu/I) large subunit; Calpain mu-type; calpain, large polypeptide L1; Calpain-1 catalytic subunit; Calpain-1 large subunit; CAN1; CANP; CANP 1; CANP1; CANPL1; CAPN1; Cell proliferation-inducing gene 30 protein; cell proliferation-inducing protein 30; Micromolar-calpain; muCANP; muCL Gene Symbols: CAPN1 Molecular weight: 81,890 Da Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Apoptosis  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below calpain 1 1ZCM - A=33-353 (human) 2ARY - A/B=27-360 (human) 1KXR - A/B=27-356 (rat) 1QXP - A/B=60-647 (rat) 1TL9 - A=27-356 (rat) 1TLO - A=27-356 (rat) 2G8E - A=27-356 (rat) 2G8J - A=27-356 (rat) 2NQG - A=27-356 (rat) 2NQI - A=27-356 (rat) 2R9C - A=27-356 (rat) 2R9F - A=27-356 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ZCM 2ARY  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K71-u	VPQSLGYkDLGPNSS
0	1		K36-u	GRHENAIkYLGQDyE
0	1		Y42-p	IkYLGQDyEQLRVRC
0	1		K79-u	DLGPNSSkTYGIkWK
0	1		K84-a	SSkTYGIkWKRPTEL
0	1		K84-u	SSkTYGIkWKRPTEL
0	1		K193-u	FWSALLEkAYAKVNG
0	1		K229-m3	TEWYELRkAPSDLYQ
0	1		K229-u	TEWYELRkAPSDLYQ
0	1		K266	DMEAITFKKLVKGHA
0	1		K280-u	AYSVTGAkQVNYRGQ
0	1		K328-u	ERDQLRVkMEDGEFW
0	1		R347	DFMREFTRLEICNLt
0	1		T354-p	RLEICNLtPDALkSR
0	4		K359-u	NLtPDALkSRTIRkW
0	2		K365-u	LkSRTIRkWNTTLyE
0	4		Y371-p	RkWNTTLyEGtWRRG
0	6		T374-p	NTTLyEGtWRRGSTA
0	6		Y387-p	TAGGCRNyPATFWVN
0	1		T390	GCRNyPATFWVNPQF
0	2		K398-u	FWVNPQFkIRLDETD
0	5		Y410-p	ETDDPDDyGDRESGC
0	1		K461-u	GQPAVHLkRDFFLAN
0	1		K505-u	PSTFEPNkEGDFVLR
0	1		K564-u	EDMEISVkELRTILN
0	1		S622	NRIRNYLSIFRKFDL
0	1		S632	RKFDLDKSGSMSAYE
0	1		S634	FDLDKSGSMSAYEMR
0	1		S636	LDKSGSMSAYEMRMA
0	1		Y638	KSGSMSAYEMRMAIE

	mouse
K71	VSHSLGFKELGPHSS
K36	GRHENAIKYLGQDYE
Y42	IKYLGQDYETLRARC
K79	ELGPHSSKTYGIKWK
K84	SSKTYGIKWKRPTEL
K84	SSKTYGIKWKRPTEL
K193	FWSALLEKAYAKVNG
K229	TEWYDLQKAPSDLYQ
K229	TEWYDLQKAPSDLYQ
K266-u	DLEAITFkNLVRGHA
K280	AYSVTGAKQVTYQGQ
K328	EREQLRVKMEDGEFW
K347-u	DFIREFTkLEICNLT
T354	kLEICNLTPDALkSR
K359-u	NLTPDALkSRTLRNW
N365	LkSRTLRNWNTTFYE
Y371	RNWNTTFYEGTWRRG
T374	NTTFYEGTWRRGSTA
Y387-p	TAGGCRNyPAtFWVN
T390-p	GCRNyPAtFWVNPQF
K398-u	FWVNPQFkIRLEEVD
Y410	EVDDADDYDNRESGC
K460	AGQPVHLKRDFFLAN
K504	PSTFEPNKEGDFLLR
K563	DDMEISVKELQTILN
T621-p	NRIRNYLtIFRKFDL
S631-p	RKFDLDKsGsMsAyE
S633-p	FDLDKsGsMsAyEMR
S635-p	LDKsGsMsAyEMRMA
Y637-p	KsGsMsAyEMRMAIE

	rat
K71	VSHSLGFKELGPNSS
K36	GRHENAIKYLGQDYE
Y42	IKYLGQDYENLRARC
K79	ELGPNSSKTYGIKWK
K84	SSKTYGIKWKRPTEL
K84	SSKTYGIKWKRPTEL
K193	FWSALLEKAYAKVNG
K229	TEWYDLQKAPSDLYQ
K229	TEWYDLQKAPSDLYQ
K266	DLEAITFKNLVRGHA
K280	AYSVTDAKQVTYQGQ
K328	EREQLRVKMEDGEFW
K347	DFIREFTKLEICNLT
T354	KLEICNLTPDALKSR
K359	NLTPDALKSRTLRNW
N365	LKSRTLRNWNTTFYE
Y371	RNWNTTFYEGTWRRG
T374	NTTFYEGTWRRGSTA
Y387	TAGGCRNYPATFWVN
T390	GCRNYPATFWVNPQF
K398	FWVNPQFKIRLEEVD
Y410	EVDDADDYDSRESGC
K460	AGQPVHLKRDFFLAN
K504	PSTFEPNKEGDFLLR
K563	DDMEISVKELQTILN
T621	NRIRNYLTIFRKFDL
S631	RKFDLDKSGSMSAYE
S633	FDLDKSGSMSAYEMR
S635	LDKSGSMSAYEMRMA
Y637	KSGSMSAYEMRMAIE

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