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Protein Page:
TYMS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TYMS an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer. Note: This description may include information from UniProtKB.
Protein type: Methyltransferase; DNA repair, damage; Nucleotide Metabolism - pyrimidine; EC 2.1.1.45; Cofactor and Vitamin Metabolism - one carbon pool by folate; Mitochondrial
Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; nucleolus; cytosol; nucleus
Molecular Function: mRNA binding; protein homodimerization activity; nucleotide binding; drug binding; cofactor binding; thymidylate synthase activity; folic acid binding
Biological Process: uracil metabolic process; immortalization of host cell by virus; methylation; tetrahydrofolate metabolic process; circadian rhythm; developmental growth; response to organophosphorus; response to toxin; response to glucocorticoid stimulus; dTTP biosynthetic process; response to vitamin A; pyrimidine base metabolic process; response to folic acid; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; polysaccharide metabolic process; DNA replication; aging; response to drug; organ regeneration; phosphoinositide-mediated signaling; nucleobase, nucleoside and nucleotide metabolic process; dTMP biosynthetic process; DNA repair; deoxyribonucleoside monophosphate biosynthetic process; G1/S-specific transcription in mitotic cell cycle; response to ethanol; cartilage development; response to cytokine stimulus; pyrimidine nucleoside biosynthetic process; dUMP metabolic process; mitotic cell cycle; response to progesterone stimulus; G1/S transition of mitotic cell cycle
Reference #:  P04818 (UniProtKB)
Alt. Names/Synonyms: HST422; MGC88736; Thymidylate synthase; thymidylate synthetase; TMS; TS; TSase; TYMS; TYSY
Gene Symbols: TYMS
Molecular weight: 35,716 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TYMS

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: S124‑p
protein conformation: S124‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MPVAGsELPRRPL
0 1 T53-p RKDDRTGtGTLSVFG
0 2 K77-ub EFPLLTTkRVFWKGV
0 3 K93-ub EELLWFIkGSTNAkE
0 2 K99-ub IkGSTNAkELSSkGV
0 2 K104-ub NAkELSSkGVkIWDA
0 4 K107-ub ELSSkGVkIWDANGs
0 5 S114-p kIWDANGsRDFLDsL
0 1 S120-p GsRDFLDsLGFsTRE
2 0 S124-p FLDsLGFsTREEGDL
0 6 Y135-p EGDLGPVyGFQWRHF
0 4 Y146-p WRHFGAEyRDMEsDy
0 2 S151-p AEyRDMEsDysGQGV
0 21 Y153-p yRDMEsDysGQGVDQ
0 1 S154-p RDMEsDysGQGVDQL
0 1 T167-p QLQRVIDtIkTNPDD
0 19 K169-ub QRVIDtIkTNPDDRR
0 1 K284-ub PKLRILRkVEkIDDF
0 2 K287-ub RILRkVEkIDDFkAE
1 0 K292-sm VEkIDDFkAEDFQIE
0 1 K292-ub VEkIDDFkAEDFQIE
0 12 K308-ub YNPHPTIkMEMAV__
  mouse

 
S6 __MLVVGSELQSDAQ
T47 KKEDRTGTGTLSVFG
K71 EFPLLTTKRVFWKGV
K87 EELLWFIKGSTNAKE
K93 IKGSTNAKELSSKGV
K98 NAKELSSKGVRIWDA
R101 ELSSKGVRIWDANGs
S108-p RIWDANGsRDFLDSL
S114 GsRDFLDSLGFSARQ
S118 FLDSLGFSARQEGDL
Y129 EGDLGPVYGFQWRHF
Y140 WRHFGAEYKDMDSDY
S145 AEYKDMDSDYSGQGV
Y147 YKDMDSDYSGQGVDQ
S148 KDMDSDYSGQGVDQL
T161 QLQKVIDTIKTNPDD
K163 QKVIDTIKTNPDDRR
K278 PKLKILRKVETIDDF
T281 KILRKVETIDDFKVE
K286 VETIDDFKVEDFQIE
K286 VETIDDFKVEDFQIE
K302 YNPHPTIKMEMAV__
  rat

 
S6 __MLVEGSELQSGAQ
T47 KKEDRTGTGTLSVFG
K71 EFPLLTTKRVFWKGV
K87 EELLWFIKGSTNAKE
K93 IKGSTNAKELSSKGV
K98 NAKELSSKGVRIWDA
R101 ELSSKGVRIWDANGS
S108 RIWDANGSRDFLDSL
S114 GSRDFLDSLGFSARQ
S118 FLDSLGFSARQEGDL
Y129 EGDLGPVYGFQWRHF
Y140 WRHFGADYKDMDSDY
S145 ADYKDMDSDYSGQGV
Y147 YKDMDSDYSGQGVDQ
S148 KDMDSDYSGQGVDQL
T161 QLQKVIDTIKTNPDD
K163 QKVIDTIKTNPDDRR
K278 PKLRILRKVETIDDF
T281 RILRKVETIDDFKVE
K286 VETIDDFKVEDFQIE
K286 VETIDDFKVEDFQIE
K302 YNPHPTIKMEMAV__
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