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TYMS (human)

Overview TYMS an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer. Note: This description may include information from UniProtKB. Protein type: Nucleotide Metabolism - pyrimidine; EC 2.1.1.45; DNA repair; Cofactor and Vitamin Metabolism - one carbon pool by folate; Mitochondrial; Methyltransferase Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; cytosol; nucleus Molecular Function: nucleotide binding; cofactor binding; thymidylate synthase activity; folic acid binding Biological Process: response to drug; immortalization of host cell by virus; developmental growth; organ regeneration; response to organophosphorus; phosphoinositide-mediated signaling; nucleobase, nucleoside and nucleotide metabolic process; response to glucocorticoid stimulus; dTTP biosynthetic process; dTMP biosynthetic process; DNA repair; deoxyribonucleoside monophosphate biosynthetic process; G1/S-specific transcription in mitotic cell cycle; pyrimidine base metabolic process; cartilage development; pyrimidine nucleoside biosynthetic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; dUMP metabolic process; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle; aging Reference #:  P04818 (UniProtKB) Alt. Names/Synonyms: HST422; MGC88736; Thymidylate synthase; thymidylate synthetase; TMS; TS; TSase; TYMS; TYSY Gene Symbols: TYMS Molecular weight: 35,716 Da Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TYMS 1HVY - A/B/C/D=26-313 (human) 1HW3 - A=1-313 (human) 1HW4 - A=1-313 (human) 1HZW - A/B=30-313 (human) 1I00 - A/B=30-313 (human) 1JU6 - A/B/C/D=1-313 (human) 1JUJ - A/B/C/D=1-313 (human) 1YPV - A=0-312 (human) 2ONB - A=1-313 (human) 2RD8 - A/B=1-313 (human) 2RDA - F/A/D/C/E/B=1-313 (human) 3EAW - X=1-313 (human) 3EBU - A=1-313 (human) 3ED7 - A=1-313 (human) 3EDW - X=1-313 (human) 3EF9 - A=1-313 (human) 3EGY - X=1-313 (human) 3EHI - X=1-313 (human) 3EJL - A/D/C/B=1-313 (human) 3GG5 - A/D/C/B=1-313 (human) 3GH0 - A=1-313 (human) 3GH2 - X=1-313 (human) 3H9K - A/D/C/E/B=1-313 (human) 3HB8 - A/D/C/E/B=1-313 (human) 3N5E - A/B=1-313 (human) 3N5G - A=1-313 (human) 3OB7 - A/D/C/E/B=1-313 (human) 4E28 - A=1-313 (human) 4FGT - A=29-311 (human) 4GYH - A=1-313 (human) 4H1I - A/D/C/B=1-313 (human) 3IHH - F/A/D/C/E/B=1-307 (mouse) 3IHI - A/B=1-307 (mouse) 4E5O - F/A/D/C/E/B=1-307 (mouse) 4EB4 - A/D/C/B=1-307 (mouse) 4EIN - A/B=1-307 (mouse) 4EZ8 - A=1-307 (mouse) 1RTS (rat) 2TSR (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4GYH 4H1I  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: S124‑p protein conformation: S124‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S6-p	__MPVAGsELPRRPL
0	1		T53-p	RKDDRTGtGTLSVFG
0	2		K77-u	EFPLLTTkRVFWKGV
0	3		K93-u	EELLWFIkGSTNAkE
0	2		K99-u	IkGSTNAkELSSkGV
0	2		K104-u	NAkELSSkGVkIWDA
0	4		K107-u	ELSSkGVkIWDANGs
0	2		S114-p	kIWDANGsRDFLDSL
2	0		S124-p	FLDSLGFsTREEGDL
0	3		Y135-p	EGDLGPVyGFQWRHF
0	10		Y146-p	WRHFGAEyRDMEsDy
0	2		S151-p	AEyRDMEsDysGQGV
0	34		Y153-p	yRDMEsDysGQGVDQ
0	1		S154-p	RDMEsDysGQGVDQL
0	1		T167-p	QLQRVIDtIkTNPDD
0	19		K169-u	QRVIDtIkTNPDDRR
0	1		K284-u	PKLRILRkVEkIDDF
0	2		K287-u	RILRkVEkIDDFkAE
1	0		K292-s	VEkIDDFkAEDFQIE
0	1		K292-u	VEkIDDFkAEDFQIE
0	12		K308-u	YNPHPTIkMEMAV__

	mouse
S6	__MLVVGSELQSDAQ
T47	KKEDRTGTGTLSVFG
K71	EFPLLTTKRVFWKGV
K87	EELLWFIKGSTNAKE
K93	IKGSTNAKELSSKGV
K98	NAKELSSKGVRIWDA
R101	ELSSKGVRIWDANGs
S108-p	RIWDANGsRDFLDSL
S118	FLDSLGFSARQEGDL
Y129	EGDLGPVYGFQWRHF
Y140	WRHFGAEYKDMDSDY
S145	AEYKDMDSDYSGQGV
Y147	YKDMDSDYSGQGVDQ
S148	KDMDSDYSGQGVDQL
T161	QLQKVIDTIKTNPDD
K163	QKVIDTIKTNPDDRR
K278	PKLKILRKVETIDDF
T281	KILRKVETIDDFKVE
K286	VETIDDFKVEDFQIE
K286	VETIDDFKVEDFQIE
K302	YNPHPTIKMEMAV__

	rat
S6	__MLVEGSELQSGAQ
T47	KKEDRTGTGTLSVFG
K71	EFPLLTTKRVFWKGV
K87	EELLWFIKGSTNAKE
K93	IKGSTNAKELSSKGV
K98	NAKELSSKGVRIWDA
R101	ELSSKGVRIWDANGS
S108	RIWDANGSRDFLDSL
S118	FLDSLGFSARQEGDL
Y129	EGDLGPVYGFQWRHF
Y140	WRHFGADYKDMDSDY
S145	ADYKDMDSDYSGQGV
Y147	YKDMDSDYSGQGVDQ
S148	KDMDSDYSGQGVDQL
T161	QLQKVIDTIKTNPDD
K163	QKVIDTIKTNPDDRR
K278	PKLRILRKVETIDDF
T281	RILRKVETIDDFKVE
K286	VETIDDFKVEDFQIE
K286	VETIDDFKVEDFQIE
K302	YNPHPTIKMEMAV__

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