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Protein Page:
Myb (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Myb Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nuclear matrix
Molecular Function: protein binding; chromatin binding
Biological Process: positive regulation of histone H3-K9 methylation; thymus development; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; B cell differentiation; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation; embryonic gut development; G1/S transition of mitotic cell cycle
Reference #:  P10242 (UniProtKB)
Alt. Names/Synonyms: c-myb; c-myb protein (140 AA); c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; c-myb_CDS; Cmyb; efg; MYB; Proto-oncogene c-Myb; Transcriptional activator Myb; v-myb myeloblastosis viral oncogene homolog (avian)
Gene Symbols: MYB
Molecular weight: 72,341 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Myb

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S11‑p, S12‑p
molecular association, regulation: S11‑p, S12‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
5 1 S11-p RPRHSIYssDEDDED
5 2 S12-p PRHSIYssDEDDEDF
0 1 Y69-p DWKVIANyLPNRTDV
0 2 K84-ub QCQHRWQkVLNPELI
0 2 K109-ub RVIELVQkYGPkRWS
0 1 K113-ub LVQkYGPkRWSVIAK
1 0 S116 kYGPkRWSVIAKHLK
1 0 P208 ESSKASQPAVATSFQ
1 0 T354 CLGEHHSTPSLPADP
0 1 S418 NSDLEMPSLtSTPLI
0 1 T420-p DLEMPSLtSTPLIGH
0 1 T433-p GHKLTVTtPFHRDQT
1 0 K442 FHRDQTVKTQKENTV
1 0 K445 DQTVKTQKENTVFRT
1 0 T448 VKTQKENTVFRTPAI
0 1 S458 RTPAIKRSILESsPR
0 1 S463-p KRSILESsPRtPTPF
0 7 T466-p ILESsPRtPTPFkHA
1 3 K471-ac PRtPTPFkHALAAQE
1 1 K480-ac ALAAQEIkYGPLkML
1 0 K485-ac EIkYGPLkMLPQTPS
2 0 T490 PLkMLPQTPSHLVED
5 0 K503-sm EDLQDVIkQESDESG
4 0 K527-sm PPLLKKIkQEVEsPt
5 5 S532-p KIkQEVEsPtDKSGN
0 1 T534-p kQEVEsPtDKSGNFF
1 0 S560 TQLFTQTSPVADAPN
3 0 A576 LTSSVLMAPASEDED
0 1 S599-p PKNRSLAsPLQPCSS
0 1 T621-p GKMEEQMtSSsQARK
0 1 S624-p EEQMtSSsQARKYVN
  Myb iso4  
S11 RPRHSIYSSDEDDED
S12 PRHSIYSSDEDDEDF
Y69 DWKVIANYLPNRTDV
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWS
K113 LVQKYGPKRWSVIAK
S116 KYGPKRWSVIAKHLK
P208 ESSKASQPAVATSFQ
T354 CLGEHHSTPSLPADP
S539 NSDLEMPSLTSTPLI
T541 DLEMPSLTSTPLIGH
T554 GHKLTVTTPFHRDQT
K563 FHRDQTVKTQKENTV
K566 DQTVKTQKENTVFRT
T569 VKTQKENTVFRTPAI
S579 RTPAIKRSILESSPR
S584 KRSILESSPRTPTPF
T587 ILESSPRTPTPFKHA
K592 PRTPTPFKHALAAQE
K601 ALAAQEIKYGPLKML
K606 EIKYGPLKMLPQTPS
T611 PLKMLPQTPSHLVED
K624 EDLQDVIKQESDESG
K648 PPLLKKIKQEVESPT
S653 KIKQEVESPTDKSGN
T655 KQEVESPTDKSGNFF
S681 TQLFTQTSPVADAPN
A697 LTSSVLMAPASEDED
S720 PKNRSLASPLQPCSS
T742 GKMEEQMTSSSQARK
S745 EEQMTSSSQARKYVN
  Myb iso11  
S11 RPRHSIYSSDEDDED
S12 PRHSIYSSDEDDEDF
Y69 DWKVIANYLPNRTDV
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWS
K113 LVQKYGPKRWSVIAK
S116 KYGPKRWSVIAKHLK
P208 ESSKASQPAVATSFQ
- gap
S333-p NSDLEMPsLTSTPLI
T335 DLEMPsLTSTPLIGH
T348 GHKLTVTTPFHRDQT
K357 FHRDQTVKTQKENTV
K360 DQTVKTQKENTVFRT
T363 VKTQKENTVFRTPAI
S373 RTPAIKRSILESSPR
S378 KRSILESSPRTPTPF
T381 ILESSPRTPTPFKHA
K386 PRTPTPFKHALAAQE
K395 ALAAQEIKYGPLKML
K400 EIKYGPLKMLPQTPS
T405 PLKMLPQTPSHLVED
K418 EDLQDVIKQESDESG
K442 PPLLKKIKQEVESPT
S447 KIKQEVESPTDKSGN
T449 KQEVESPTDKSGNFF
S475 TQLFTQTSPVADAPN
A491 LTSSVLMAPASEDED
S514 PKNRSLASPLQPCSS
T536 GKMEEQMTSSSQARK
S539 EEQMTSSSQARKYVN
  mouse

 
S11-p RPRHSIYssDEDDED
S12-p PRHSIYssDEDDEDI
Y69 DWKVIANYLPNRTDV
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWS
K113 LVQKYGPKRWSVIAK
S116 KYGPKRWSVIAKHLK
T208-p EPSKASQtPVATSFQ
T354-p CLGEHHAtPSLPADP
T418 SSGLDAPTLPSTPLI
P420 GLDAPTLPSTPLIGH
- gap
K438-ac PCRDQTVkTQkENsI
K441-ac DQTVkTQkENsIFRT
S444-p VkTQkENsIFRTPAI
S454-gl RTPAIKRsILESSPR
S459 KRsILESSPRTPTPF
T462 ILESSPRTPTPFKHA
K467 PRTPTPFKHALAAQE
K476 ALAAQEIKYGPLKML
K481 EIKYGPLKMLPQtPS
T486-p PLKMLPQtPSHAVED
K499-sm EDLQDVIkQESDESG
K523-sm PPLLKKIkQEVEsPT
S528-p KIkQEVEsPTEKSGN
T530 kQEVEsPTEKSGNFF
S556-p TQLFSQAsPVADAPN
T572-p LTSSVLMtPVSEDED
G595 PKNRPLVGPLQPCSG
T617 GKTEDQMTASGPARK
G620 EDQMTASGPARKYVN
  rat

 
S12 RPVHSIYSSDEDDED
S13 PVHSIYSSDEDDEDI
- under review  
K86 QCQHRWQKVLNPELI
K111 RVIELVQKYGPKRWS
K115 LVQKYGPKRWSVIAK
S118 KYGPKRWSVIAKHLK
- under review  
T349 CLGENHATPSLPADP
T526 NSGLDTPTLPSTPLI
P528 GLDTPTLPSTPLIGH
- under review  
K547 CHRDQTVKTQkENSI
K550-ac DQTVKTQkENSIFRT
S553 VKTQkENSIFRTPAI
S563 RTPAIKRSILESSPR
S568 KRSILESSPRTPTPF
T571 ILESSPRTPTPFkHA
K576-ac PRTPTPFkHALAAQE
K585 ALAAQEIKYGPLKML
K590 EIKYGPLKMLPQTPS
T595 PLKMLPQTPSHVVED
K608 EDLQDVIKQESDESG
K632 PPLLKKIKQEVDsPT
S637-p KIKQEVDsPTEKAGN
T639 KQEVDsPTEKAGNFF
S665 TQLFAQASPVADAPN
T681 LTSSVLMTPVSEDED
G704 PKNRPLVGPLQPCVG
T727 GKTEDQMTASGQARK
G730 EDQMTASGQARKYVN
  chicken

 
S11-p RPRHSIYssDDDEED
S12-p PRHSIYssDDDEEDV
F69 DWKVIASFLPNRTDV
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWs
K113 LVQKYGPKRWsVIAK
S116-p KYGPKRWsVIAKHLK
P208 ESSKAGLPSATTGFQ
T355 LGEHHHCTPSPPVDH
A419 NLNLDNPALTSTPVC
T421 NLDNPALTSTPVCGH
T434 GHKMSVTTPFHRDQP
K443 FHRDQPFKTQKENHV
K446 DQPFKTQKENHVFRT
H449 FKTQKENHVFRTPAI
S459 RTPAIKRSILESSPR
S464 KRSILESSPRTPTPF
T467 ILESSPRTPTPFKNA
K472 PRTPTPFKNALAAQE
K481 ALAAQEIKYGPLKML
K486 EIKYGPLKMLPQTPT
T491 PLKMLPQTPTHLVED
K504 EDLQDVIKQESEESA
K528 PPLLKKIKQEVESPT
S533 KIKQEVESPTDKAGN
T535 KQEVESPTDKAGNFF
S561 TQLFTHASTMEDVPN
M577 LTSSILKMPVSEEEG
S600 PRNRPLASPMQHLNN
A622 GKTEDQMALTDQARK
D625 EDQMALTDQARKYMA
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