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Myb (human)

Overview Myb Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: nuclear matrix Molecular Function: protein binding; DNA binding; chromatin binding; transcription factor activity Biological Process: positive regulation of histone H3-K9 methylation; transcription, DNA-dependent; thymus development; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; B cell differentiation; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transcription, DNA-dependent; embryonic gut development; G1/S transition of mitotic cell cycle Reference #:  P10242 (UniProtKB) Alt. Names/Synonyms: c-myb; c-myb protein (140 AA); c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; c-myb_CDS; Cmyb; efg; MYB; Proto-oncogene c-Myb; Transcriptional activator Myb; v-myb myeloblastosis viral oncogene homolog (avian) Gene Symbols: MYB Molecular weight: 72,341 Da Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Myb 1GUU - A=38-89 (mouse) 1GV2 - A=89-193 (mouse) 1GV5 - A=90-141 (mouse) 1GVD - A=90-141 (mouse) 1H88 - C=37-193 (mouse) 1H89 - C=37-193 (mouse) 1IDY - A=141-193 (mouse) 1IDZ - A=141-193 (mouse) 1MBE - A=38-89 (mouse) 1MBF - A=38-89 (mouse) 1MBG - A=90-141 (mouse) 1MBH - A=90-141 (mouse) 1MBJ - A=142-193 (mouse) 1MBK - A=142-193 (mouse) 1MSE - C=90-193 (mouse) 1MSF - C=90-193 (mouse) 1SB0 - B=291-315 (mouse) 2AGH - A=291-315 (mouse) 1POM - A=142-192 (chicken)

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	Sites Implicated In
transcription, altered: S11‑p, S12‑p molecular association, regulation: S11‑p, S12‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
5	1		S11-p	RPRHSIYssDEDDED
5	2		S12-p	PRHSIYssDEDDEDF
0	1		Y69-p	DWKVIANyLPNRTDV
0	2		K84-u	QCQHRWQkVLNPELI
0	2		K109-u	RVIELVQkYGPkRWS
0	1		K113-u	LVQkYGPkRWSVIAK
1	0		S116	kYGPkRWSVIAKHLK
1	0		T354	CLGEHHSTPSLPADP
0	1		S418	NSDLEMPSLtSTPLI
0	1		T420-p	DLEMPSLtSTPLIGH
0	1		T433-p	GHKLTVTtPFHRDQT
1	0		K442	FHRDQTVKTQKENTV
1	0		K445	DQTVKTQKENTVFRT
0	1		S458	RTPAIKRSILESsPR
0	1		S463-p	KRSILESsPRtPTPF
0	7		T466-p	ILESsPRtPTPFkHA
1	3		K471-a	PRtPTPFkHALAAQE
1	1		K480-a	ALAAQEIkYGPLkML
1	0		K485-a	EIkYGPLkMLPQTPS
1	0		T490	PLkMLPQTPSHLVED
4	0		K503-s	EDLQDVIkQESDESG
4	0		K527-s	PPLLKKIkQEVEsPT
5	4		S532-p	KIkQEVEsPTDKSGN
1	0		S560	TQLFTQTSPVADAPN
3	0		A576	LTSSVLMAPASEDED

	Myb iso4
S11	RPRHSIYSSDEDDED
S12	PRHSIYSSDEDDEDF
Y69	DWKVIANYLPNRTDV
K84	QCQHRWQKVLNPELI
K109	RVIELVQKYGPKRWS
K113	LVQKYGPKRWSVIAK
S116	KYGPKRWSVIAKHLK
T354	CLGEHHSTPSLPADP
S539	NSDLEMPSLTSTPLI
T541	DLEMPSLTSTPLIGH
T554	GHKLTVTTPFHRDQT
K563	FHRDQTVKTQKENTV
K566	DQTVKTQKENTVFRT
S579	RTPAIKRSILESSPR
S584	KRSILESSPRTPTPF
T587	ILESSPRTPTPFKHA
K592	PRTPTPFKHALAAQE
K601	ALAAQEIKYGPLKML
K606	EIKYGPLKMLPQTPS
T611	PLKMLPQTPSHLVED
K624	EDLQDVIKQESDESG
K648	PPLLKKIKQEVESPT
S653	KIKQEVESPTDKSGN
S681	TQLFTQTSPVADAPN
A697	LTSSVLMAPASEDED

	Myb iso5
S11	RPRHSIYSSDEDDED
S12	PRHSIYSSDEDDEDF
Y69	DWKVIANYLPNRTDV
K84	QCQHRWQKVLNPELI
K109	RVIELVQKYGPKRWS
K113	LVQKYGPKRWSVIAK
S116	KYGPKRWSVIAKHLK
-	gap
S333-p	NSDLEMPsLTSTPLI
T335	DLEMPsLTSTPLIGH
T348	GHKLTVTTPFHRDQT
K357	FHRDQTVKTQKENTV
K360	DQTVKTQKENTVFRT
S373	RTPAIKRSILESSPR
S378	KRSILESSPRTPTPF
T381	ILESSPRTPTPFKHA
K386	PRTPTPFKHALAAQE
K395	ALAAQEIKYGPLKML
K400	EIKYGPLKMLPQTPS
T405	PLKMLPQTPSHLVED
K418	EDLQDVIKQESDESG
K442	PPLLKKIKQEVESPT
S447	KIKQEVESPTDKSGN
S475	TQLFTQTSPVADAPN
A491	LTSSVLMAPASEDED

	mouse
S11-p	RPRHSIYssDEDDED
S12-p	PRHSIYssDEDDEDI
Y69	DWKVIANYLPNRTDV
K84	QCQHRWQKVLNPELI
K109	RVIELVQKYGPKRWS
K113	LVQKYGPKRWSVIAK
S116	KYGPKRWSVIAKHLK
T354-p	CLGEHHAtPSLPADP
T418	SSGLDAPTLPSTPLI
P420	GLDAPTLPSTPLIGH
-	gap
K438-a	PCRDQTVkTQkENSI
K441-a	DQTVkTQkENSIFRT
S454-g	RTPAIKRsILESSPR
S459	KRsILESSPRTPTPF
T462	ILESSPRTPTPFKHA
K467	PRTPTPFKHALAAQE
K476	ALAAQEIKYGPLKML
K481	EIKYGPLKMLPQtPS
T486-p	PLKMLPQtPSHAVED
K499-s	EDLQDVIkQESDESG
K523-s	PPLLKKIkQEVEsPT
S528-p	KIkQEVEsPTEKSGN
S556-p	TQLFSQAsPVADAPN
T572-p	LTSSVLMtPVSEDED

	chicken
S11-p	RPRHSIYssDDDEED
S12-p	PRHSIYssDDDEEDV
F69	DWKVIASFLPNRTDV
K84	QCQHRWQKVLNPELI
K109	RVIELVQKYGPKRWs
K113	LVQKYGPKRWsVIAK
S116-p	KYGPKRWsVIAKHLK
T355	LGEHHHCTPSPPVDH
A419	NLNLDNPALTSTPVC
T421	NLDNPALTSTPVCGH
T434	GHKMSVTTPFHRDQP
K443	FHRDQPFKTQKENHV
K446	DQPFKTQKENHVFRT
S459	RTPAIKRSILESSPR
S464	KRSILESSPRTPTPF
T467	ILESSPRTPTPFKNA
K472	PRTPTPFKNALAAQE
K481	ALAAQEIKYGPLKML
K486	EIKYGPLKMLPQTPT
T491	PLKMLPQTPTHLVED
K504	EDLQDVIKQESEESA
K528	PPLLKKIKQEVESPT
S533	KIKQEVESPTDKAGN
S561	TQLFTHASTMEDVPN
M577	LTSSILKMPVSEEEG

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