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Protein Page:
Myb (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Myb Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nuclear matrix
Molecular Function: protein binding; DNA binding; chromatin binding; transcription factor activity
Biological Process: positive regulation of histone H3-K9 methylation; transcription, DNA-dependent; thymus development; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; calcium ion transport; B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transcription, DNA-dependent; embryonic gut development; G1/S transition of mitotic cell cycle
Reference #:  P10242 (UniProtKB)
Alt. Names/Synonyms: c-myb; c-myb protein (140 AA); c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; c-myb_CDS; Cmyb; efg; MYB; Proto-oncogene c-Myb; Transcriptional activator Myb; v-myb myeloblastosis viral oncogene homolog (avian)
Gene Symbols: MYB
Molecular weight: 72,341 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Myb

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S11‑p, S12‑p
molecular association, regulation: S11‑p, S12‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
5 1 S11-p RPRHSIYssDEDDED
5 2 S12-p PRHSIYssDEDDEDF
0 2 K84-u QCQHRWQkVLNPELI
0 2 K109-u RVIELVQkYGPKRWS
1 0 S116 kYGPKRWSVIAKHLK
1 0 P208 ESSKASQPAVATSFQ
1 0 T354 CLGEHHSTPSLPADP
1 0 K442 FHRDQTVKTQKENTV
1 0 K445 DQTVKTQKENTVFRT
1 0 T448 VKTQKENTVFRTPAI
0 1 S458 RTPAIKRSILESSPR
0 7 T466-p ILESSPRtPTPFkHA
1 3 K471-a PRtPTPFkHALAAQE
1 1 K480-a ALAAQEIkYGPLkML
1 0 K485-a EIkYGPLkMLPQTPS
2 0 T490 PLkMLPQTPSHLVED
5 0 K503-s EDLQDVIkQESDESG
4 0 K527-s PPLLKKIkQEVEsPt
5 5 S532-p KIkQEVEsPtDKSGN
0 1 T534-p kQEVEsPtDKSGNFF
1 0 S560 TQLFTQTSPVADAPN
3 0 A576 LTSSVLMAPASEDED
0 1 S599-p PKNRSLAsPLQPCSS
  Myb iso4  
S11 RPRHSIYSSDEDDED
S12 PRHSIYSSDEDDEDF
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWS
S116 KYGPKRWSVIAKHLK
P208 ESSKASQPAVATSFQ
T354 CLGEHHSTPSLPADP
K563 FHRDQTVKTQKENTV
K566 DQTVKTQKENTVFRT
T569 VKTQKENTVFRTPAI
S579 RTPAIKRSILESSPR
T587 ILESSPRTPTPFKHA
K592 PRTPTPFKHALAAQE
K601 ALAAQEIKYGPLKML
K606 EIKYGPLKMLPQTPS
T611 PLKMLPQTPSHLVED
K624 EDLQDVIKQESDESG
K648 PPLLKKIKQEVESPT
S653 KIKQEVESPTDKSGN
T655 KQEVESPTDKSGNFF
S681 TQLFTQTSPVADAPN
A697 LTSSVLMAPASEDED
S720 PKNRSLASPLQPCSS
  Myb iso11  
S11 RPRHSIYSSDEDDED
S12 PRHSIYSSDEDDEDF
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWS
S116 KYGPKRWSVIAKHLK
P208 ESSKASQPAVATSFQ
- gap
K357 FHRDQTVKTQKENTV
K360 DQTVKTQKENTVFRT
T363 VKTQKENTVFRTPAI
S373 RTPAIKRSILESSPR
T381 ILESSPRTPTPFKHA
K386 PRTPTPFKHALAAQE
K395 ALAAQEIKYGPLKML
K400 EIKYGPLKMLPQTPS
T405 PLKMLPQTPSHLVED
K418 EDLQDVIKQESDESG
K442 PPLLKKIKQEVESPT
S447 KIKQEVESPTDKSGN
T449 KQEVESPTDKSGNFF
S475 TQLFTQTSPVADAPN
A491 LTSSVLMAPASEDED
S514 PKNRSLASPLQPCSS
  mouse

 
S11-p RPRHSIYssDEDDED
S12-p PRHSIYssDEDDEDI
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWS
S116 KYGPKRWSVIAKHLK
T208-p EPSKASQtPVATSFQ
T354-p CLGEHHAtPSLPADP
K438-a PCRDQTVkTQkENsI
K441-a DQTVkTQkENsIFRT
S444-p VkTQkENsIFRTPAI
S454-gl RTPAIKRsILESSPR
T462 ILESSPRTPTPFKHA
K467 PRTPTPFKHALAAQE
K476 ALAAQEIKYGPLKML
K481 EIKYGPLKMLPQtPS
T486-p PLKMLPQtPSHAVED
K499-s EDLQDVIkQESDESG
K523-s PPLLKKIkQEVEsPT
S528-p KIkQEVEsPTEKSGN
T530 kQEVEsPTEKSGNFF
S556-p TQLFSQAsPVADAPN
T572-p LTSSVLMtPVSEDED
G595 PKNRPLVGPLQPCSG
  chicken

 
S11-p RPRHSIYssDDDEED
S12-p PRHSIYssDDDEEDV
K84 QCQHRWQKVLNPELI
K109 RVIELVQKYGPKRWs
S116-p KYGPKRWsVIAKHLK
P208 ESSKAGLPSATTGFQ
T355 LGEHHHCTPSPPVDH
K443 FHRDQPFKTQKENHV
K446 DQPFKTQKENHVFRT
H449 FKTQKENHVFRTPAI
S459 RTPAIKRSILESSPR
T467 ILESSPRTPTPFKNA
K472 PRTPTPFKNALAAQE
K481 ALAAQEIKYGPLKML
K486 EIKYGPLKMLPQTPT
T491 PLKMLPQTPTHLVED
K504 EDLQDVIKQESEESA
K528 PPLLKKIKQEVESPT
S533 KIKQEVESPTDKAGN
T535 KQEVESPTDKAGNFF
S561 TQLFTHASTMEDVPN
M577 LTSSILKMPVSEEEG
- under review  
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