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Protein Page:
CETN2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CETN2 a calcium-binding proteins and is a structural component of the centrosome. Contains 4 EF-hand calcium-binding domains. Highly conserved from algae to humans. Its association with the centrosome suggests that it plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Cell cycle regulation; DNA repair, damage
Cellular Component: centriole; centrosome; intracellular; cytosol; photoreceptor connecting cilium
Molecular Function: protein binding; nucleic acid binding; microtubule binding; G-protein beta/gamma-subunit binding; ATP-dependent helicase activity; calcium ion binding; ATP binding; heterotrimeric G-protein binding
Biological Process: ATP catabolic process; mitosis; nucleotide-excision repair; spermatogenesis; centriole replication; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cytokinesis
Reference #:  P41208 (UniProtKB)
Alt. Names/Synonyms: CALT; caltractin (20kD calcium-binding protein); Caltractin isoform 1; CEN2; centrin, EF-hand protein, 2; Centrin-2; CETN2
Gene Symbols: CETN2
Molecular weight: 19,738 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CETN2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S170‑p
cell growth, altered: S170‑p
intracellular localization: T118‑p
protein stabilization: S170‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MAsNFkKANM
0 2 K6-ac __MAsNFkKANMASs
0 1 S13-p kKANMASssQRKRMs
0 8 S14-p KANMASssQRKRMsP
0 24 S20-p ssQRKRMsPKPELtE
0 9 T26-p MsPKPELtEEQKQEI
0 1 G87 GTGKMNFGDFLTVMT
0 1 K111-ub EEILKAFkLFDDDEt
1 0 T118-p kLFDDDEtGkISFkN
0 19 K120-ub FDDDEtGkISFkNLk
0 5 K124-ub EtGkISFkNLkRVAK
0 3 K127-ub kISFkNLkRVAKELG
0 1 K131 kNLkRVAKELGENLt
2 2 T138-p KELGENLtDEELQEM
1 0 S158-p RDGDGEVsEQEFLRI
3 0 S170-p LRIMKKTsLY_____
  mouse

 
S3 _____MASNFKKTTM
K6 __MASNFKKTTMASS
S13 KKTTMASSAQRKRMs
A14 KTTMASSAQRKRMsP
S20-p SAQRKRMsPKPELtE
T26-p MsPKPELtEDQKQEI
S87-p GTGKMNFsDFLTVMT
K111 EEILKAFKLFDDDET
T118 KLFDDDETGkISFkN
K120-ub FDDDETGkISFkNLk
K124-ub ETGkISFkNLkRVAk
K127-ub kISFkNLkRVAkELG
K131-ub kNLkRVAkELGENLt
T138-p kELGENLtDEELQEM
N158 RDGDGEVNEQEFLRI
S170 LRIMKKTSLY_____
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