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CETN2 (human)

Overview CETN2 a calcium-binding proteins and is a structural component of the centrosome. Contains 4 EF-hand calcium-binding domains. Highly conserved from algae to humans. Its association with the centrosome suggests that it plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: centriole; centrosome; intracellular; cytosol; photoreceptor connecting cilium; basal body Molecular Function: protein binding; nucleic acid binding; microtubule binding; G-protein beta/gamma-subunit binding; ATP-dependent helicase activity; calcium ion binding; ATP binding; heterotrimeric G-protein binding Biological Process: mitosis; cell division; nucleotide-excision repair; centriole replication; spermatogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cytokinesis Reference #:  P41208 (UniProtKB) Alt. Names/Synonyms: CALT; caltractin (20kD calcium-binding protein); Caltractin isoform 1; CEN2; centrin, EF-hand protein, 2; Centrin-2; CETN2 Gene Symbols: CETN2 Molecular weight: 19,738 Da Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CETN2 1M39 - A=84-172 (human) 1ZMZ - A=1-98 (human) 2A4J - A=94-172 (human) 2GGM - A/B=1-172 (human) 2K2I - A=94-172 (human) 2OBH - A/B=26-168 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1M39 1ZMZ 2A4J 2GGM 2K2I 2OBH  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S170‑p cell growth, altered: S170‑p protein stabilization: S170‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3-p	_____MAsNFkKANM
0	2		K6-a	__MAsNFkKANMASs
0	1		S13-p	kKANMASssQRKRMs
0	8		S14-p	KANMASssQRKRMsP
0	18		S20-p	ssQRKRMsPKPELtE
0	7		T26-p	MsPKPELtEEQKQEI
0	1		G87	GTGKMNFGDFLTVMT
0	1		K111-u	EEILKAFkLFDDDET
0	19		K120-u	FDDDETGkISFkNLk
0	5		K124-u	ETGkISFkNLkRVAK
0	3		K127-u	kISFkNLkRVAKELG
0	1		K131	kNLkRVAKELGENLt
0	2		T138-p	KELGENLtDEELQEM
2	0		S170-p	LRIMKKTsLY_____

	mouse
S3	_____MASNFKKTTM
K6	__MASNFKKTTMASS
S13	KKTTMASSAQRKRMs
A14	KTTMASSAQRKRMsP
S20-p	SAQRKRMsPKPELtE
T26-p	MsPKPELtEDQKQEI
S87-p	GTGKMNFsDFLTVMT
K111	EEILKAFKLFDDDET
K120-u	FDDDETGkISFkNLk
K124-u	ETGkISFkNLkRVAk
K127-u	kISFkNLkRVAkELG
K131-u	kNLkRVAkELGENLt
T138-p	kELGENLtDEELQEM
S170	LRIMKKTSLY_____

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