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Protein Page:
HAND1 (human)

Overview
HAND1 Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). Note: This description may include information from UniProtKB.
Protein type: Nucleolus; DNA binding protein; Cell development/differentiation; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: identical protein binding; protein binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; bHLH transcription factor binding; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; blastocyst development; negative regulation of transcription factor activity; heart development; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation; odontogenesis of dentine-containing teeth; mesoderm formation; ventricular cardiac muscle morphogenesis; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; heart looping; angiogenesis; negative regulation of transcription, DNA-dependent
Reference #:  O96004 (UniProtKB)
Alt. Names/Synonyms: BHLHA27; Class A basic helix-loop-helix protein 27; EHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; HAND1; heart and neural crest derivatives expressed 1; Heart- and neural crest derivatives-expressed protein 1; Hxt; Thing1
Gene Symbols: HAND1
Molecular weight: 23,627 Da
Basal Isoelectric point: 9.69  Predict pI for various phosphorylation states
Select Structure to View Below

HAND1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S98-p RLGRRKGsGPKKERR
1 0 T107 PKKERRRTESINSAF
1 0 S109 KERRRTESINSAFAE
  mouse

 
S98 RLPKRKGSGPKKERR
T107-p PKKERRRtEsINSAF
S109-p KERRRtEsINSAFAE
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