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TSPO (human)

Overview TSPO Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Receptor, misc.; Mitochondrial; Apoptosis; Membrane protein, integral Cellular Component: mitochondrial outer membrane; integral to membrane Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding Biological Process: response to drug; steroid metabolic process; adrenal gland development; apoptosis; positive regulation of apoptosis; negative regulation of nitric oxide biosynthetic process; regulation of steroid biosynthetic process; negative regulation of tumor necrosis factor production; response to testosterone stimulus; glial cell migration; axon regeneration in the peripheral nervous system; anion transport; response to vitamin B1; response to manganese ion; cell proliferation; behavioral response to pain; positive regulation of mitochondrial depolarization; positive regulation of calcium ion transport; response to progesterone stimulus; regulation of cholesterol transport; protein targeting to mitochondrion; steroid biosynthetic process; heme biosynthetic process; aging Reference #:  P30536 (UniProtKB) Alt. Names/Synonyms: benzodiazepine peripheral binding site; BZRP; DBI; IBP; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Translocator protein; translocator protein (18kDa); TSPO; TSPOA Gene Symbols: TSPO Molecular weight: 18,828 Da Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

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	Modification Sites and Domains

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