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Protein Page:
TSPO (human)

TSPO Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Apoptosis; Membrane protein, multi-pass; Receptor, misc.; Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: mitochondrial outer membrane; nuclear membrane; intracellular membrane-bound organelle; mitochondrion; cytoplasm; integral to membrane
Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding
Biological Process: steroid metabolic process; positive regulation of apoptosis; apoptosis; regulation of steroid biosynthetic process; axon regeneration in the peripheral nervous system; anion transport; response to vitamin B1; synaptic transmission; behavioral response to pain; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; aging; response to drug; adrenal gland development; negative regulation of nitric oxide biosynthetic process; chloride transport; negative regulation of tumor necrosis factor production; response to testosterone stimulus; lipid transport; glial cell migration; response to manganese ion; cell proliferation; positive regulation of calcium ion transport; regulation of cholesterol transport; response to progesterone stimulus; steroid biosynthetic process; heme biosynthetic process
Reference #:  P30536 (UniProtKB)
Alt. Names/Synonyms: benzodiazepine peripheral binding site; BZRP; DBI; IBP; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; RP3-526I14.4; Translocator protein; translocator protein (18kDa); TSPO; TSPOA
Gene Symbols: TSPO
Molecular weight: 18,828 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains  

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