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ADAM22 (human)

Overview ADAM22 Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: integral to membrane Molecular Function: integrin binding; protein binding; zinc ion binding; metalloendopeptidase activity Biological Process: central nervous system development; adult locomotory behavior; negative regulation of cell adhesion; cell adhesion; proteolysis; myelination in the peripheral nervous system Reference #:  Q9P0K1 (UniProtKB) Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 22; ADA22; ADAM 22; ADAM metallopeptidase domain 22; ADAM22; Disintegrin and metalloproteinase domain-containing protein 22; MDC2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; MGC149832 Gene Symbols: ADAM22 Molecular weight: 100,433 Da Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states

Select Structure to View Below ADAM22 3G5C - A/B=233-736 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S834‑p, S857‑p molecular association, regulation: S834‑p, S857‑p protein stabilization: S834‑p, S857‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S32-p	CGQAGDAsLMELEKR
0	1		T262-p	HRLSVVHtNtYAKSV
0	1		T264-p	LSVVHtNtYAKSVVN
0	1		S302-p	TDNKFAIsENPLItL
0	1		T308-p	IsENPLItLREFMKY
0	1		S389	SDKRKLASGECKCED
0	1		S800	STNSASSSKKRSNGL
0	1		S804	ASSSKKRSNGLSHSW
0	7		S810	RSNGLSHSWSERIPD
0	3		S812	NGLSHSWSERIPDTK
0	1		K819	SERIPDTKHIsDICE
0	1		S822-p	IPDTKHIsDICENGR
0	4		S832-p	CENGRPRsNsWQGNL
1	100		S834-p	NGRPRsNsWQGNLGG
0	5		S855-p	GKRFRPRsNstETLS
1	60		S857-p	RFRPRsNstETLSPA
0	4		T858-p	FRPRsNstETLSPAK
0	1		-	gap
0	2		-	gap
0	1		T860	PRsNstETLSPAKSP
0	2		S862	sNstETLSPAKSPSs
0	4		S866	ETLSPAKSPSsstGs
0	3		S868	LSPAKSPSsstGsIA
0	4		S869-p	SPAKSPSsstGsIAS
0	5		S870-p	PAKSPSsstGsIASS
0	2		T871-p	AKSPSsstGsIASSR
0	4		S873-p	SPSsstGsIASSRKy
0	1		Y880-p	sIASSRKyPyPMPPL
0	7		Y882-p	ASSRKyPyPMPPLPD

	ADAM22 iso2
S32	CGQAGDASLMELEKR
T262	HRLSVVHTNTYAKSV
T264	LSVVHTNTYAKSVVN
S302	TDNKFAISENPLITL
T308	ISENPLITLREFMKY
S389	SDKRKLASGECKCED
-	under review
S768	KNYREQRSNGLSHSW
S774	RSNGLSHSWSERIPD
S776	NGLSHSWSERIPDTK
K783	SERIPDTKHISDICE
S786	IPDTKHISDICENGR
S796	CENGRPRSNsWQGNL
S798-p	NGRPRSNsWQGNLGG
S819-p	GKRFRPRsNsTEyLN
S821-p	RFRPRsNsTEyLNPW
T822	FRPRsNsTEyLNPWF
Y824-p	PRsNsTEyLNPWFKR
Y850-p	NKNTEGPyFRTLSPA
T853	TEGPyFRTLSPAKSP
S855	GPyFRTLSPAKSPSS
S859	RTLSPAKSPSSSTGS
S861	LSPAKSPSSSTGSIA
S862	SPAKSPSSSTGSIAS
S863	PAKSPSSSTGSIASS
T864	AKSPSSSTGSIASSR
S866	SPSSSTGSIASSRKY
Y873	SIASSRKYPYPMPPL
Y875	ASSRKYPYPMPPLPD

	mouse ► Hide Isoforms
S30	CGRAGVASLKGLERG
T260	HRLSVVYTNTYAKSV
T262	LSVVYTNTYAKSVVN
S300	ADNKFAISENPLITL
T306	ISENPLITLREFMKY
S387-p	SDKRKLAsGECKCED
S798-p	STNSASSsKKRsNGL
S802-p	ASSsKKRsNGLSHsW
S808-p	RsNGLSHsWsERIPD
S810-p	NGLSHsWsERIPDTk
K817-u	sERIPDTkHISDICE
S820	IPDTkHISDICENGR
S830-p	CENGRPRsNsWQGNM
S832-p	NGRPRsNsWQGNMGG
S853-p	GKRFRPRsNsTEtLs
S855-p	RFRPRsNsTEtLsPA
T856	FRPRsNsTEtLsPAK
-	gap
-	gap
T858-p	PRsNsTEtLsPAKsP
S860-p	sNsTEtLsPAKsPss
S864-p	EtLsPAKsPssstGs
S866-p	LsPAKsPssstGsIA
S867-p	sPAKsPssstGsIAS
S868-p	PAKsPssstGsIASS
T869-p	AKsPssstGsIASSR
S871-p	sPssstGsIASSRKY
Y878	sIASSRKYPYPMPPL
Y880	ASSRKYPYPMPPLPD

	ADAM22 iso8
S30	CGRAGVASLKGLERG
T260	HRLSVVYTNTYAKSV
T262	LSVVYTNTYAKSVVN
S300	ADNKFAISENPLITL
T306	ISENPLITLREFMKY
S387	SDKRKLASGECKCED
-	under review
S766	KNYREQRSNGLSHsW
S772-p	RSNGLSHsWSERIPD
S774	NGLSHsWSERIPDTK
K781	SERIPDTKHISDICE
S784	IPDTKHISDICENGR
S794	CENGRPRSNsWQGNM
S796-p	NGRPRSNsWQGNMGG
S817-p	GKRFRPRsNstEYLN
S819-p	RFRPRsNstEYLNPW
T820-p	FRPRsNstEYLNPWF
Y822	PRsNstEYLNPWFKR
Y848	NKNTEGPYFSSQDSP
T861	SPHQQDRTLsPAKsP
S863-p	HQQDRTLsPAKsPss
S867-p	RTLsPAKsPssstGs
S869-p	LsPAKsPssstGsIA
S870-p	sPAKsPssstGsIAS
S871-p	PAKsPssstGsIASS
T872-p	AKsPssstGsIASSR
S874-p	sPssstGsIASSRKY
Y881	sIASSRKYPYPMPPL
Y883	ASSRKYPYPMPPLPD

	ADAM22 iso11
S30	CGRAGVASLKGLERG
T260	HRLSVVYTNTYAKSV
T262	LSVVYTNTYAKSVVN
S300	ADNKFAISENPLITL
T306	ISENPLITLREFMKY
S387	SDKRKLASGECKCED
S798	STNSASSSKKRSNGL
S802	ASSSKKRSNGLSHSW
S808	RSNGLSHSWSERIPD
S810	NGLSHSWSERIPDTK
K817	SERIPDTKHISDICE
S820	IPDTKHISDICENGR
S830	CENGRPRSNSWQGNM
S832	NGRPRSNSWQGNMGG
S853	GKRFRPRSNSTEREP
S855	RFRPRSNSTEREPQA
T856	FRPRSNSTEREPQAP
Y895	TGSLDHRYLNPWFKR
Y921	NKNTEGPYFRTLSPA
T924	TEGPYFRTLSPAKSP
S926	GPYFRTLSPAKSPSS
S930	RTLSPAKSPSSSTGS
S932	LSPAKSPSSSTGSIA
S933	SPAKSPSSSTGSIAS
S934	PAKSPSSSTGSIASS
T935	AKSPSSSTGSIASSR
S937	SPSSSTGSIASSRKY
Y944	SIASSRKYPYPMPPL
Y946	ASSRKYPYPMPPLPD

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