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Protein Page:
ADAM22 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADAM22 Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: integral to membrane
Molecular Function: integrin binding; protein binding; zinc ion binding; metalloendopeptidase activity
Biological Process: central nervous system development; adult locomotory behavior; negative regulation of cell adhesion; cell adhesion; proteolysis; myelination in the peripheral nervous system
Reference #:  Q9P0K1 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 22; ADA22; ADAM 22; ADAM metallopeptidase domain 22; ADAM22; Disintegrin and metalloproteinase domain-containing protein 22; MDC2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; MGC149832
Gene Symbols: ADAM22
Molecular weight: 100,433 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Select Structure to View Below

ADAM22

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S834‑p, S857‑p
molecular association, regulation: S834‑p, S857‑p
protein stabilization: S834‑p, S857‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S32-p CGQAGDAsLMELEKR
0 1 T262-p HRLSVVHtNtYAKSV
0 1 T264-p LSVVHtNtYAKSVVN
0 1 S302-p TDNKFAIsENPLItL
0 1 T308-p IsENPLItLREFMKY
0 1 S389 SDKRKLASGECKCED
0 1 Y556-p TRDRQCKyIWGQKVT
0 1 S565-p WGQKVTAsDKYCYEK
0 1 S800 STNSASSSKKRSNGL
0 1 S804 ASSSKKRSNGLSHSW
0 7 S810 RSNGLSHSWsERIPD
0 4 S812-p NGLSHSWsERIPDTK
0 1 K819 sERIPDTKHIsDICE
0 1 S822-p IPDTKHIsDICENGR
0 5 S832-p CENGRPRsNsWQGNL
1 105 S834-p NGRPRsNsWQGNLGG
0 6 S855-p GKRFRPRsNstETLS
1 72 S857-p RFRPRsNstETLSPA
0 4 T858-p FRPRsNstETLSPAK
0 1 - gap
0 2 - gap
0 1 T860 PRsNstETLSPAKSP
0 2 S862 sNstETLSPAKSPSs
0 4 S866 ETLSPAKSPSsstGs
0 3 S868 LSPAKSPSsstGsIA
0 6 S869-p SPAKSPSsstGsIAS
0 6 S870-p PAKSPSsstGsIASS
0 2 T871-p AKSPSsstGsIASSR
0 5 S873-p SPSsstGsIASSRKy
0 1 Y880-p sIASSRKyPyPMPPL
0 7 Y882-p ASSRKyPyPMPPLPD
  ADAM22 iso2  
S32 CGQAGDASLMELEKR
T262 HRLSVVHTNTYAKSV
T264 LSVVHTNTYAKSVVN
S302 TDNKFAISENPLITL
T308 ISENPLITLREFMKY
S389 SDKRKLASGECKCED
Y556 TRDRQCKYIWGQKVT
S565 WGQKVTASDKYCYEK
- gap
S768 KNYREQRSNGLSHSW
S774 RSNGLSHSWSERIPD
S776 NGLSHSWSERIPDTK
K783 SERIPDTKHISDICE
S786 IPDTKHISDICENGR
S796 CENGRPRSNsWQGNL
S798-p NGRPRSNsWQGNLGG
S819-p GKRFRPRsNsTEyLN
S821-p RFRPRsNsTEyLNPW
T822 FRPRsNsTEyLNPWF
Y824-p PRsNsTEyLNPWFKR
Y850-p NKNTEGPyFRTLSPA
T853 TEGPyFRTLSPAKSP
S855 GPyFRTLSPAKSPSs
S859 RTLSPAKSPSsSTGs
S861 LSPAKSPSsSTGsIA
S862-p SPAKSPSsSTGsIAS
S863 PAKSPSsSTGsIASS
T864 AKSPSsSTGsIASSR
S866-p SPSsSTGsIASSRKY
Y873 sIASSRKYPYPMPPL
Y875 ASSRKYPYPMPPLPD
  mouse

► Hide Isoforms
 
S30 CGRAGVASLKGLERG
T260 HRLSVVYTNTYAKSV
T262 LSVVYTNTYAKSVVN
S300 ADNKFAISENPLITL
T306 ISENPLITLREFMKY
S387-p SDKRKLAsGECKCED
Y554 TRDRQCKYIWGQKVT
S563 WGQKVTASDRYCYEK
S798-p STNSASSsKKRsNGL
S802-p ASSsKKRsNGLSHsW
S808-p RsNGLSHsWsERIPD
S810-p NGLSHsWsERIPDTk
K817-ub sERIPDTkHISDICE
S820 IPDTkHISDICENGR
S830-p CENGRPRsNsWQGNM
S832-p NGRPRsNsWQGNMGG
S853-p GKRFRPRsNsTEtLs
S855-p RFRPRsNsTEtLsPA
T856 FRPRsNsTEtLsPAK
- gap
- gap
T858-p PRsNsTEtLsPAKsP
S860-p sNsTEtLsPAKsPss
S864-p EtLsPAKsPssstGs
S866-p LsPAKsPssstGsIA
S867-p sPAKsPssstGsIAS
S868-p PAKsPssstGsIASS
T869-p AKsPssstGsIASSR
S871-p sPssstGsIASSRKY
Y878 sIASSRKYPYPMPPL
Y880 ASSRKYPYPMPPLPD
  ADAM22 iso8  
S30 CGRAGVASLKGLERG
T260 HRLSVVYTNTYAKSV
T262 LSVVYTNTYAKSVVN
S300 ADNKFAISENPLITL
T306 ISENPLITLREFMKY
S387 SDKRKLASGECKCED
Y554 TRDRQCKYIWGQKVT
S563 WGQKVTASDRYCYEK
- gap
S766 KNYREQRSNGLSHsW
S772-p RSNGLSHsWSERIPD
S774 NGLSHsWSERIPDTK
K781 SERIPDTKHISDICE
S784 IPDTKHISDICENGR
S794 CENGRPRSNsWQGNM
S796-p NGRPRSNsWQGNMGG
S817-p GKRFRPRsNstEYLN
S819-p RFRPRsNstEYLNPW
T820-p FRPRsNstEYLNPWF
Y822 PRsNstEYLNPWFKR
Y848 NKNTEGPYFSSQDSP
T861 SPHQQDRTLsPAKsP
S863-p HQQDRTLsPAKsPss
S867-p RTLsPAKsPssstGs
S869-p LsPAKsPssstGsIA
S870-p sPAKsPssstGsIAS
S871-p PAKsPssstGsIASS
T872-p AKsPssstGsIASSR
S874-p sPssstGsIASSRKY
Y881 sIASSRKYPYPMPPL
Y883 ASSRKYPYPMPPLPD
  ADAM22 iso11  
S30 CGRAGVASLKGLERG
T260 HRLSVVYTNTYAKSV
T262 LSVVYTNTYAKSVVN
S300 ADNKFAISENPLITL
T306 ISENPLITLREFMKY
S387 SDKRKLASGECKCED
Y554 TRDRQCKYIWGQKVT
S563 WGQKVTASDRYCYEK
S798 STNSASSSKKRSNGL
S802 ASSSKKRSNGLSHSW
S808 RSNGLSHSWSERIPD
S810 NGLSHSWSERIPDTK
K817 SERIPDTKHISDICE
S820 IPDTKHISDICENGR
S830 CENGRPRSNSWQGNM
S832 NGRPRSNSWQGNMGG
S853 GKRFRPRSNSTEREP
S855 RFRPRSNSTEREPQA
T856 FRPRSNSTEREPQAP
Y895 TGSLDHRYLNPWFKR
Y921 NKNTEGPYFRTLSPA
T924 TEGPYFRTLSPAKSP
S926 GPYFRTLSPAKSPSS
S930 RTLSPAKSPSSSTGS
S932 LSPAKSPSSSTGSIA
S933 SPAKSPSSSTGSIAS
S934 PAKSPSSSTGSIASS
T935 AKSPSSSTGSIASSR
S937 SPSSSTGSIASSRKY
Y944 SIASSRKYPYPMPPL
Y946 ASSRKYPYPMPPLPD
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