Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 7q21
Cellular Component: axon; integral to membrane
Molecular Function: integrin binding; protein binding; zinc ion binding; metalloendopeptidase activity
Biological Process: central nervous system development; adult locomotory behavior; negative regulation of cell adhesion; cell adhesion; proteolysis; myelination in the peripheral nervous system
Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 22; ADA22; ADAM 22; ADAM metallopeptidase domain 22; ADAM22; Disintegrin and metalloproteinase domain-containing protein 22; MDC2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; MGC149832
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.