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Protein Page:
ORC1L (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ORC1L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Belongs to the ORC1 family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleolus; cytosol; nucleus; nuclear origin of replication recognition complex; origin recognition complex
Molecular Function: protein binding; DNA binding; nucleoside-triphosphatase activity; chromatin binding; ATP binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; DNA replication initiation; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
Reference #:  Q13415 (UniProtKB)
Alt. Names/Synonyms: HSORC1; ORC1; ORC1L; origin recognition complex 1; Origin recognition complex subunit 1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition complex, subunit 1-like (yeast); PARC1; Replication control protein 1
Gene Symbols: ORC1
Molecular weight: 97,350 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ORC1L

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6 __MAHYPTRLKTRKT
0 1 S194-p QKPVRAKsKsAEsPs
0 1 S196-p PVRAKsKsAEsPsWt
0 3 S199-p AKsKsAEsPsWtPAE
0 1 S201-p sKsAEsPsWtPAEHV
0 5 T203-p sAEsPsWtPAEHVAK
0 1 S221-p SRHSASKsRQtPTHP
0 6 T224-p SASKsRQtPTHPLtP
0 10 T230-p QtPTHPLtPRARKRL
0 1 S252 PQMSQQTSCAsLDsP
0 2 S255-p SQQTSCAsLDsPGRI
1 2 S258-p TSCAsLDsPGRIKRK
0 1 S269-p IKRKVAFsEITsPsK
1 5 S273-p VAFsEITsPsKRSQP
0 1 S275-p FsEITsPsKRSQPDK
0 5 S287-p PDKLQTLsPALKAPE
0 8 S311-p TEDDKKAsPEHRIIL
0 1 K326-ac RTRIAASkTIDIREE
0 9 T337-p IREERTLtPIsGGQR
0 3 S340-p ERTLtPIsGGQRSSV
0 1 K354 VVPSVILKPENIKKR
0 1 K364-ac NIKKRDAkEAKAQNE
0 2 T373-p AKAQNEAtStPHRIR
1 6 T375-p AQNEAtStPHRIRRK
0 4 S383-p PHRIRRKssVLTMNR
0 3 S384-p HRIRRKssVLTMNRI
0 2 S417-p ILPAAEIsDsssDEE
0 1 S419-p PAAEIsDsssDEEEA
0 2 S420-p AAEIsDsssDEEEAS
0 2 S421-p AEIsDsssDEEEAST
0 1 S449-p NLRSSLKssLHtLtK
0 1 S450-p LRSSLKssLHtLtKV
0 1 T453-p SLKssLHtLtKVPKK
0 1 T455-p KssLHtLtKVPKKsL
0 1 S461-p LtKVPKKsLKPRTPR
0 3 S478-p APQIRSRsLAAQEPA
0 5 S850-p LRVRLNVsQDDVLYA
0 1 K859-ub DDVLYALkDE_____
  mouse

► Hide Isoforms
 
T6-p __MPSYLtRQKTRQT
I192 QKPLKAKIKNVKSPA
N194 PLKAKIKNVKSPARN
S197 AKIKNVKSPARNTTE
A199 IKNVKSPARNTTEQE
N201 NVKSPARNTTEQEVK
F219 SNHSTSKFHQTPANI
T222 STSKFHQTPANIVIP
I228 QTPANIVIPNAKKSL
S255-p TRWSKKSsCDsLDYQ
S258-p SKKSsCDsLDYQKTS
Y261 SsCDsLDYQKTSKRR
S272 SKRRAAFSETTsPPK
S276-p AAFSETTsPPKKPNK
P278 FSETTsPPKKPNKPR
S290 KPREIKPSSALETRV
C306 NGQTQPFCAKSSVVL
T321 RARNPAMTTTKLGVD
S332-p LGVDNTLsPIRNGLR
R335 DNTLsPIRNGLRSSV
T349-p VVPSGGLtPVYIRRK
K358 VYIRRKAKEQETHKE
R368 ETHKEPIRTSRVHRK
S370 HKEPIRTSRVHRKss
S376-p TSRVHRKssLLTLKR
S377-p SRVHRKssLLTLKRI
- gap
S406 EEEESVDSESEEEDE
E407 EEESVDSESEEEDEF
S408 EESVDSESEEEDEFI
- gap
T429 NSLGQSRTRQTPSKS
T432 GQSRTRQTPSKSPQK
S434 SRTRQTPSKSPQKNP
N440 PSKSPQKNPKPRTPH
N457 TPQIRDRNLAVQEPA
S829 LRVRLNVSQNDVLFA
K838 NDVLFALKEE_____
  ORC1L var1  
T6 __MPSYLTRQKTRQT
I192 QKPLKAKIKNVKSPA
N194 PLKAKIKNVKSPARN
S197 AKIKNVKSPARNTTE
A199 IKNVKSPARNTTEQE
N201 NVKSPARNTTEQEVK
F219 SNHSTSKFHQTPANI
T222 STSKFHQTPANIVIP
I228 QTPANIVIPsAKKSL
S255 TRWSKKSSCDSLDYQ
S258 SKKSSCDSLDYQKTS
Y261 SSCDSLDYQKTSKRR
S272 SKRRAAFSETTSPPK
S276 AAFSETTSPPKKPNK
P278 FSETTSPPKKPNKPR
S290 KPREIKPSSALETRV
C306 NGQTQPFCAKSSVVL
T321 RARNPAMTTTKLGVD
S332 LGVDNTLSPIRNGLR
R335 DNTLSPIRNGLRSSV
T349 VVPSGGLTPVYIRRK
K358 VYIRRKAKEQETHKE
R368 ETHKEPIRTSRVHRK
S370 HKEPIRTSRVHRKSS
S376 TSRVHRKSSLLTLKR
S377 SRVHRKSSLLTLKRI
- gap
S406 EEEESVDSESEEEDE
E407 EEESVDSESEEEDEF
S408 EESVDSESEEEDEFI
- gap
T429 NSLGQSRTRQTPSKS
T432 GQSRTRQTPSKSPQK
S434 SRTRQTPSKSPQKNP
N440 PSKSPQKNPKPRTPH
N457 TPQIRDRNLAVQEPA
S829 LRVRLNVSQNDVLFA
K838 NDVLFALKEE_____
  rat

 
T6 __MPSYVTRQKTRQT
T188 QKPLEAKTKSVKSPS
S190 PLEAKTKSVKSPSWS
S193 AKTKSVKSPSWSTAE
S195 TKSVKSPSWSTAEQE
S197 SVKSPSWSTAEQEVK
S215 SSHSTSRSYQDPAHT
D218 STSRSYQDPAHTVTP
T224 QDPAHTVTPNAMKSL
L249 MRLSRKILCDSLDSQ
S252 SRKILCDSLDSQKTC
S255 ILCDSLDSQKTCKRR
S266 CKRRAAFSETTSPPK
S270 AAFSETTSPPKKPQP
P272 FSETTSPPKKPQPGE
S283 QPGEIKTSSALETLG
F299 NGHTQPFFAKSSMVL
K314 RTRGTAVKTTKLTVE
S325-p LTVESALsPVRSRSR
R328 ESALsPVRSRSRYSV
T342 VAPSVGLTPQYIGRK
K351 QYIGRKAKEQETHKE
H361 ETHKEPIHTSLRARR
S363 HKEPIHTSLRARRRS
S370 SLRARRRSSLLTLKR
S371 LRARRRSSLLTLKRI
S404 SISSVEVSDSSSEEE
S406 SSVEVSDSSSEEEDE
S407 SVEVSDSSSEEEDES
S408 VEVSDSSSEEEDESV
- gap
S437 RRTASKPSSQTPSKS
T440 ASKPSSQTPSKSPKK
S442 KPSSQTPSKSPKKTF
T448 PSKSPKKTFRPRPPL
N465 TPQIRDRNLAVQEPA
S837 LRVRLNVSQNDVLYA
K846 NDVLYALKEE_____
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