Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Blk (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Blk a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; TK group; Src family
Cellular Component: plasma membrane
Molecular Function: protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of insulin secretion
Reference #:  P51451 (UniProtKB)
Alt. Names/Synonyms: B lymphocyte kinase; B lymphoid tyrosine kinase; BLK; BLK nonreceptor tyrosine kinase; MGC10442; p55-Blk; Tyrosine-protein kinase Blk
Gene Symbols: BLK
Molecular weight: 57,706 Da
Basal Isoelectric point: 7.98  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Blk

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K157-u IRESETNkGAFSLSV
0 144 Y187-p RCLDEGGyyISPRIT
0 95 Y188-p CLDEGGyyISPRITF
1 2 Y205-p LQALVQHySKKGDGL
0 2 Y309-p VVTKEPIyIVTEYMA
0 4 K325-u GCLLDFLkTDEGSRL
0 7 K375-u VSEALCCkIADFGLA
0 78 Y389-p ARIIDSEyTAQEGAK
2 16 Y501-p YTATERQyELQP___
  mouse

 
K151 IRESESNKGAFSLSV
Y181-p RSLDNGGyyISPRIT
Y182-p SLDNGGyyISPRITF
Y199 LQALVQHYSKKGDGL
Y303-p VVTREPIyIVTEYMA
K319 GCLLDFLKTDEGSRL
K369 VSETLCCKIADFGLA
Y383-p ARIIDSEyTAQEGAK
Y495-p YTATEGQyELQP___
  rat

 
K151 IRESESNKGAFSLSV
Y181 RSLDNGGYYISPRIT
Y182 SLDNGGYYISPRITF
Y199 LQALVQHYSEKGDGL
Y303 VVTREPIYIVTEYMA
K319 GCLLDFLKTDEGSRL
K369 VSETLCCKIADFGLA
Y383 ARIIDSEYTAQEGAK
Y495 YTATEGQYELQP___
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.