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Protein Page:
Blk (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Blk a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Src family
Cellular Component: plasma membrane
Molecular Function: protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: B cell receptor signaling pathway; protein kinase cascade; positive regulation of insulin secretion
Reference #:  P51451 (UniProtKB)
Alt. Names/Synonyms: B lymphocyte kinase; B lymphoid tyrosine kinase; BLK; BLK nonreceptor tyrosine kinase; MGC10442; p55-Blk; Tyrosine-protein kinase Blk
Gene Symbols: BLK
Molecular weight: 57,706 Da
Basal Isoelectric point: 7.98  Predict pI for various phosphorylation states
CST Pathways:  GPCRs Signaling to MAPK/Erk  |  Tyrosine Kinases
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Blk
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 K157-u IRESETNkGAFSLSV
0 1 Y107-p LVTGREGyVPSNFVA
0 144 Y187-p RCLDEGGyyISPRIT
0 94 Y188-p CLDEGGyyISPRITF
0 1 S197-p SPRITFPsLQALVQH
1 2 Y205-p LQALVQHySKkGDGL
0 1 K208-u LVQHySKkGDGLCQR
0 1 Y300 HERLVRLYAVVTkEP
0 1 K305-u RLYAVVTkEPIyIVT
0 2 Y309-p VVTkEPIyIVTEyMA
0 1 Y314-p PIyIVTEyMARGCLL
0 4 K325-u GCLLDFLkTDEGSRL
0 7 K375-u VSEALCCkIADFGLA
0 78 Y389-p ARIIDSEyTAQEGAK
0 1 Y494-p QSVLEDFyTATERQy
2 16 Y501-p yTATERQyELQP___
  mouse

 
K151 IRESESNKGAFSLSV
Y101 LVTGREGYVPSNFVA
Y181-p RSLDNGGyyISPRIT
Y182-p SLDNGGyyISPRITF
T191 SPRITFPTLQALVQH
Y199 LQALVQHYSKKGDGL
K202 LVQHYSKKGDGLCQK
Y294-p HERLVRLyAVVTREP
R299 RLyAVVTREPIyIVT
Y303-p VVTREPIyIVTEYMA
Y308 PIyIVTEYMARGCLL
K319 GCLLDFLKTDEGSRL
K369 VSETLCCKIADFGLA
Y383-p ARIIDSEyTAQEGAK
Y488 QSVLEDFYTATEGQy
Y495-p YTATEGQyELQP___
  rat

 
K151 IRESESNKGAFSLSV
Y101 LVTGREGYVPSNFVA
Y181 RSLDNGGYYISPRIT
Y182 SLDNGGYYISPRITF
T191 SPRITFPTLQALVQH
Y199 LQALVQHYSEKGDGL
K202 LVQHYSEKGDGLCQK
Y294 HERLVRLYAVVTREP
R299 RLYAVVTREPIYIVT
Y303 VVTREPIYIVTEYMA
Y308 PIYIVTEYMARGCLL
K319 GCLLDFLKTDEGSRL
K369 VSETLCCKIADFGLA
Y383 ARIIDSEYTAQEGAK
Y488 QSVLEDFYTATEGQY
Y495 YTATEGQYELQP___
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