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Protein Page:
BST2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BST2 IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma- associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Belongs to the tetherin family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral
Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; cytoplasm; late endosome; apical plasma membrane; plasma membrane; lipid raft
Molecular Function: metalloendopeptidase inhibitor activity; protein binding; signal transducer activity; protein homodimerization activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; B cell activation; multicellular organismal development; response to virus; signal transduction; humoral immune response; cell proliferation; negative regulation of plasmacytoid dendritic cell cytokine production; negative regulation of viral genome replication; cell-cell signaling; regulation of actin cytoskeleton organization and biogenesis; innate immune response; negative regulation of cell growth; defense response to virus; negative regulation of cell migration
Reference #:  Q10589 (UniProtKB)
Alt. Names/Synonyms: Bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; BST-2; BST2; CD317; HM1.24 antigen; NPC-A-7; Tetherin
Gene Symbols: BST2
Molecular weight: 19,769 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Select Structure to View Below

BST2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 Y6-p __MASTSyDyCRVPM
0 11 Y8-p MASTSyDyCRVPMED
1 0 K18-u VPMEDGDkRCKLLLG
0 1 K106 MASLDAEKAQGQKKV
0 1 T121-ga EELEGEIttLNHKLQ
0 1 T122-ga ELEGEIttLNHKLQD
0 1 - gap
0 1 S131-ga NHKLQDAsAEVERLR
  mouse

 
Y6 __MAPSFYHYLPVPM
Y8 MAPSFYHYLPVPMDE
K19 PMDEMGGKQGWGSHR
K110-u LQESLEKkVSQALEQ
- gap
- gap
K130-u ELENEVTkLNQELEN
N132 ENEVTkLNQELENLR
  rat

 
Y6 __MAPSFYHYLPVAM
Y8 MAPSFYHYLPVAMDE
K20 MDERWEPKGWSIRRW
K110 LRDSLKKKVSQTQEQ
- gap
- gap
R130 ELENKIERLNQELEN
N132 ENKIERLNQELENLR
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