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Protein Page:
TIE2 (human)

Overview
TIE2 a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; TK group; Tie family
Cellular Component: cell surface; microvillus; focal adhesion; basolateral plasma membrane; integral to plasma membrane; extracellular region; actin filament; intercellular junction; lipid raft; cytoplasm; apical plasma membrane; stress fiber; basal plasma membrane; plasma membrane
Molecular Function: protein binding; protein-tyrosine kinase activity; growth factor binding; transmembrane receptor protein tyrosine kinase activity; receptor activity; ATP binding; protein kinase activity
Biological Process: response to peptide hormone stimulus; response to cAMP; peptidyl-tyrosine phosphorylation; heart development; cell-matrix adhesion; protein amino acid autophosphorylation; signal transduction; cell-cell adhesion; positive regulation of focal adhesion formation; cell-cell signaling; angiogenesis; endochondral ossification; organ regeneration; Tie receptor signaling pathway; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of peptidyl-serine phosphorylation; protein oligomerization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; negative regulation of angiogenesis; response to estrogen stimulus; endothelial cell proliferation; negative regulation of inflammatory response; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; regulation of vascular permeability; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Reference #:  Q02763 (UniProtKB)
Alt. Names/Synonyms: Angiopoietin-1 receptor; CD202B; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK; TEK tyrosine kinase, endothelial; TIE-2; TIE2; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1
Gene Symbols: TEK
Molecular weight: 125,830 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIE2

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y1102‑p
enzymatic activity, induced: Y1102‑p, Y1108‑p, S1119‑p
enzymatic activity, inhibited: Y897‑p
molecular association, regulation: Y1102‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y697-p KNATITQyQLKGLEP
1 25 Y897-p GACEHRGyLYLAIEY
0 11 Y976-p NILVGENyVAKIADF
2 0 Y992-p LSRGQEVyVKKTMGR
1 0 Y1048-p GMTCAELyEKLPQGY
5 0 Y1102-p MLEERKTyVNTTLyE
4 1 Y1108-p TyVNTTLyEKFTyAG
3 0 Y1113-p TLyEKFTyAGIDCsA
1 0 S1119-p TyAGIDCsAEEAA__
4221 : Phospho-Tie2 (Tyr992) Antibody
4226 : Phospho-Tie2 (Ser1119) Antibody
  mouse

 
Y696 KNATVTQYQLKGLEP
Y895 GACEHRGYLYLAIEY
Y974 NILVGENYIAKIADF
Y990 LSRGQEVYVKKTMGR
Y1046 GMTCAELYEKLPQGY
Y1100-p MLEERKTyVNTTLyE
Y1106-p TyVNTTLyEKFTyAG
Y1111-p TLyEKFTyAGIDCsA
S1117-p TyAGIDCsAEEAA__
4221 : Phospho-Tie2 (Tyr992) Antibody
4226 : Phospho-Tie2 (Ser1119) Antibody
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