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TIE2 (human)

Overview TIE2 a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; TK group; Tie family Cellular Component: focal adhesion; cell surface; microvillus; basolateral plasma membrane; integral to plasma membrane; extracellular region; actin filament; intercellular junction; lipid raft; apical plasma membrane; cytoplasm; stress fiber; plasma membrane; basal plasma membrane Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor activity; ATP binding; protein kinase activity Biological Process: peptidyl-tyrosine phosphorylation; heart development; protein amino acid autophosphorylation; cell-matrix adhesion; signal transduction; cell-cell adhesion; positive regulation of focal adhesion formation; cell-cell signaling; angiogenesis; Tie receptor signaling pathway; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of peptidyl-serine phosphorylation; protein oligomerization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; negative regulation of angiogenesis; negative regulation of inflammatory response; endothelial cell proliferation; positive regulation of endothelial cell proliferation; regulation of vascular permeability; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis Reference #:  Q02763 (UniProtKB) Alt. Names/Synonyms: Angiopoietin-1 receptor; CD202B; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK; TEK tyrosine kinase, endothelial; TIE-2; TIE2; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1 Gene Symbols: TEK Molecular weight: 125,830 Da Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TIE2 1FVR - A/B=808-1124 (human) 2GY5 - A=23-445 (human) 2GY7 - B=23-445 (human) 2OO8 - X=808-1124 (human) 2OSC - A=808-1124 (human) 2P4I - A/B=808-1124 (human) 2WQB - A=802-1124 (human) 3BEA - A=917-935 (human) 3L8P - A=808-1124 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P  |  ENZYME  |  Phospho3D  |  DISEASE 600195 600221  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: Y1102‑p enzymatic activity, induced: Y1102‑p, Y1108‑p, S1119‑p enzymatic activity, inhibited: Y897‑p molecular association, regulation: Y1102‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T115-p	GEAIRIRtMKMRQQA
0	1		S142-p	KGDNVNIsFKKVLIK
0	1		S164-p	KNGSFIHsVPRHEVP
0	1		Y816-p	NNPDPTIyPVLDWND
1	25		Y897-p	GACEHRGyLyLAIEY
0	1		Y899-p	CEHRGyLyLAIEYAP
0	11		Y976-p	NILVGENyVAKIADF
2	0		Y992-p	LSRGQEVyVKKTMGR
1	0		Y1048-p	GMTCAELyEKLPQGY
5	0		Y1102-p	MLEERKTyVNTTLyE
4	1		Y1108-p	TyVNTTLyEKFTyAG
3	0		Y1113-p	TLyEKFTyAGIDCsA
1	0		S1119-p	TyAGIDCsAEEAA__

	mouse
T115	GQAIRIRTMKMRQQA
S142	RGDNVNISFKKVLIK
S164	KNGSFIHSVPRHEVP
Y814	NNPDPTIYPVLDWND
Y895	GACEHRGYLYLAIEY
Y897	CEHRGYLYLAIEYAP
Y974	NILVGENYIAKIADF
Y990	LSRGQEVYVKKTMGR
Y1046	GMTCAELYEKLPQGY
Y1100-p	MLEERKTyVNTTLyE
Y1106-p	TyVNTTLyEKFTyAG
Y1111-p	TLyEKFTyAGIDCSA
S1117	TyAGIDCSAEEAA__

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