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Protein Page:
SEMA4B iso3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SEMA4B iso3 a single-pass type I membrane protein that inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q25
Cellular Component: integral to membrane
Molecular Function: receptor activity
Biological Process: nervous system development; cell differentiation
Reference #:  J3KNP4 (UniProtKB)
Alt. Names/Synonyms: KIAA1745; MGC131831; SEM4B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B; SEMA4B; SEMAC; Semaphorin-4B; SemC
Gene Symbols: SEMA4B
Molecular weight: 92,766 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEMA4B iso3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 Y65-p EAEHISNytALLLSR
0 1 T66-p AEHISNytALLLSRD
0 1 K403-ac TNSARERkINSSLQL
0 1 K740-ub YRHRNSMkVFLKQGE
0 1 T764-p PVVLPPEtRPLNGLG
0 1 S774-p LNGLGPPstPLDHRG
0 5 T775-p NGLGPPstPLDHRGy
0 9 Y782-p tPLDHRGyQsLSDsP
0 1 S784-p LDHRGyQsLSDsPPG
0 7 S788-p GyQsLSDsPPGSRVF
0 5 P789 yQsLSDsPPGSRVFt
0 2 T796-p PPGSRVFtESEKRPL
0 55 S804-p ESEKRPLsIQDsFVE
0 20 S808-p RPLsIQDsFVEVsPV
0 134 S813-p QDsFVEVsPVCPRPR
0 355 S825-p RPRVRLGsEIRDsVV
0 3 S830-p LGsEIRDsVV_____
5622 : Phospho-Semaphorin 4B (Ser825) Antibody
  SEMA4B iso3  
T4-p ____MLRtAMGLRSW
Y70 EAEHISNYTALLLSR
T71 AEHISNYTALLLSRD
K408 TNSARERKINSSLQL
K745 YRHRNSMKVFLKQGE
T769 PVVLPPETRPLNGLG
S779 LNGLGPPSTPLDHRG
T780 NGLGPPSTPLDHRGY
Y787 TPLDHRGYQSLSDSP
S789 LDHRGYQSLSDSPPG
S793 GYQSLSDSPPGSRVF
P794 YQSLSDSPPGSRVFT
T801 PPGSRVFTESEKRPL
S809 ESEKRPLSIQDSFVE
S813 RPLSIQDSFVEVSPV
S818 QDSFVEVSPVCPRPR
S830 RPRVRLGSEIRDSVV
S835 LGSEIRDSVV_____
5622 : Phospho-Semaphorin 4B (Ser825) Antibody
  mouse

 
- gap
Y57 EAENISNYTALLLSQ
T58 AENISNYTALLLSQD
K395 TNSARERKINSSLQL
K731 YRHRDGMKLFLKQGE
T755 PIVLPPETRPLNGVG
S765 LNGVGPPStPLDHRG
T766-p NGVGPPStPLDHRGy
Y773-p tPLDHRGyQALSDSs
A775 LDHRGyQALSDSsPG
S779 GyQALSDSsPGPRVF
S780-p yQALSDSsPGPRVFT
T787 sPGPRVFTESEKRPL
S795-p ESEKRPLsIQDsFVE
S799-p RPLsIQDsFVEVsPV
S804-p QDsFVEVsPVCPRPR
S816-p RPRVRLGsEIRDSVV
S821 LGsEIRDSVV_____
5622 : Phospho-Semaphorin 4B (Ser825) Antibody
  rat

 
- gap
Y55 EAENISNYTALLLSQ
T56 AENISNYTALLLSQD
K393 TNSARERKINSSLQL
K729 YRNRDGMKLFLKQGE
T753 PAVLPPETRPLNGVG
S763 LNGVGPPSTPLDHRG
T764 NGVGPPSTPLDHRGY
Y771 TPLDHRGYQALSDSS
A773 LDHRGYQALSDSSPG
S777 GYQALSDSSPGPRVF
S778 YQALSDSSPGPRVFT
T785 SPGPRVFTESEKRPL
S793 ESEKRPLSIQDSFVE
S797 RPLSIQDSFVEVSPV
S802 QDSFVEVSPVCPRPR
S814-p RPRVRLGsEIRDSVV
S819 LGsEIRDSVV_____
5622 : Phospho-Semaphorin 4B (Ser825) Antibody
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