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SEMA4B (human)

Overview SEMA4B a single-pass type I membrane protein that inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Cell surface; Membrane protein, integral Cellular Component: integral to membrane Molecular Function: receptor activity Biological Process: nervous system development; cell differentiation Reference #:  NP_064595 (RefSeq) Alt. Names/Synonyms: KIAA1745; MGC131831; SEM4B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B; SEMA4B; SEMAC; Semaphorin-4B; SemC Gene Symbols: SEMA4B Molecular weight: 92,766 Da Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SEMA4B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T4-p	____MLRtAMGLRSW
0	1		Y70-p	EAEHISNytALLLSR
0	1		T71-p	AEHISNytALLLSRD
0	1		K408-a	TNSARERkINSSLQL
0	1		K745-u	YRHRNSMkVFLKQGE
0	1		T769-p	PVVLPPEtRPLNGLG
0	1		S779-p	LNGLGPPstPLDHRG
0	5		T780-p	NGLGPPstPLDHRGy
0	9		Y787-p	tPLDHRGyQSLSDsP
0	2		S793-p	GyQSLSDsPPGSRVF
0	5		P794	yQSLSDsPPGSRVFt
0	2		T801-p	PPGSRVFtESEKRPL
0	54		S809-p	ESEKRPLsIQDsFVE
0	19		S813-p	RPLsIQDsFVEVsPV
0	129		S818-p	QDsFVEVsPVCPRPR
0	341		S830-p	RPRVRLGsEIRDsVV
0	3		S835-p	LGsEIRDsVV_____

	mouse
-	gap
Y57	EAENISNYTALLLSQ
T58	AENISNYTALLLSQD
K395	TNSARERKINSSLQL
K731	YRHRDGMKLFLKQGE
T755	PIVLPPETRPLNGVG
S765	LNGVGPPStPLDHRG
T766-p	NGVGPPStPLDHRGy
Y773-p	tPLDHRGyQALSDSs
S779	GyQALSDSsPGPRVF
S780-p	yQALSDSsPGPRVFT
T787	sPGPRVFTESEKRPL
S795-p	ESEKRPLsIQDsFVE
S799-p	RPLsIQDsFVEVsPV
S804-p	QDsFVEVsPVCPRPR
S816-p	RPRVRLGsEIRDSVV
S821	LGsEIRDSVV_____

	rat
-	gap
Y55	EAENISNYTALLLSQ
T56	AENISNYTALLLSQD
K393	TNSARERKINSSLQL
K729	YRNRDGMKLFLKQGE
T753	PAVLPPETRPLNGVG
S763	LNGVGPPSTPLDHRG
T764	NGVGPPSTPLDHRGY
Y771	TPLDHRGYQALSDSS
S777	GYQALSDSSPGPRVF
S778	YQALSDSSPGPRVFT
T785	SPGPRVFTESEKRPL
S793	ESEKRPLSIQDSFVE
S797	RPLSIQDSFVEVSPV
S802	QDSFVEVSPVCPRPR
S814	RPRVRLGSEIRDSVV
S819	LGSEIRDSVV_____

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