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Protein Page:
STX1A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
STX1A a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Membrane protein, integral
Cellular Component: SNARE complex; neuron projection; synaptic vesicle membrane; extracellular region; integral to membrane; plasma membrane; actomyosin; cell junction; secretory granule
Molecular Function: protein binding, bridging; SNAP receptor activity; protein domain specific binding; ATP-dependent protein binding; SNARE binding; protein binding; protein heterodimerization activity; myosin head/neck binding; protein N-terminus binding; calcium channel inhibitor activity; glycoprotein binding; calcium-dependent protein binding
Biological Process: response to gravity; intracellular protein transport; synaptic transmission; cellular protein metabolic process; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; positive regulation of neurotransmitter secretion; regulation of insulin secretion; positive regulation of exocytosis; calcium ion-dependent exocytosis; synaptic vesicle docking during exocytosis
Reference #:  Q16623 (UniProtKB)
Alt. Names/Synonyms: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A (brain); Syntaxin-1A
Gene Symbols: STX1A
Molecular weight: 33,023 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STX1A

Protein Structure Not Found.


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Sites Implicated In
exocytosis, altered: S14‑p
molecular association, regulation: S14‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T10 DRTQELRTAKDsDDD
0 1 K12 TQELRTAKDsDDDDD
4 15 S14-p ELRTAKDsDDDDDVA
1 0 A21 sDDDDDVAVtVDRDR
0 1 T23-p DDDDVAVtVDRDRFM
0 3 K46 EIRGFIDKIAENVEE
0 3 S59 EEVKRKHSAILAsPN
0 6 S64-p KHSAILAsPNPDEKT
0 1 K70 AsPNPDEKTKEELEE
0 1 S80 EELEELMSDIKKTAN
0 1 K94 NKVRSKLKSIEQSIE
0 2 S95 KVRSKLKSIEQSIEQ
1 1 S162 ITGRTTTSEELEDML
1 0 S188 IIMDSSISKQALSEI
0 2 T282-p LGIVIAStVGGIFA_
  mouse

 
T10-p DRTQELRtAkDsDDD
K12-u TQELRtAkDsDDDDD
S14-p ELRtAkDsDDDDDVT
T21 sDDDDDVTVTVDRDR
T23 DDDDVTVTVDRDRFM
K46-u EIRGFIDkIAENVEE
S59-p EEVKRKHsAILAsPN
S64-p KHsAILAsPNPDEkT
K70-u AsPNPDEkTKEELEE
S80-p EELEELMsDIKKTAN
K94-u NKVRSKLksIEQSIE
S95-p KVRSKLksIEQSIEQ
S162 ITGRTTTSEELEDML
S188 IIMDSSISKQALSEI
T282 LGIIIASTIGGIFG_
  rat

 
T10 DRTQELRTAKDsDDD
K12 TQELRTAKDsDDDDD
S14-p ELRTAKDsDDDDDVt
T21-p sDDDDDVtVTVDRDR
T23 DDDDVtVTVDRDRFM
K46-u EIRGFIDkIAENVEE
S59 EEVKRKHSAILASPN
S64 KHSAILASPNPDEKT
K70 ASPNPDEKTKEELEE
S80 EELEELMSDIKKTAN
K94 NKVRSKLKSIEQSIE
S95 KVRSKLKSIEQSIEQ
S162-p ITGRTTTsEELEDML
S188-p IIMDSSIsKQALSEI
T282 LGIIIASTIGGIFG_
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