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Protein Page:
STX1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STX1A a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: SNARE complex; neuron projection; synaptic vesicle membrane; extracellular region; integral to membrane; plasma membrane; actomyosin; cell junction; secretory granule
Molecular Function: protein binding, bridging; protein domain specific binding; SNAP receptor activity; ATP-dependent protein binding; SNARE binding; protein binding; protein heterodimerization activity; myosin head/neck binding; protein N-terminus binding; calcium channel inhibitor activity; glycoprotein binding; calcium-dependent protein binding
Biological Process: response to gravity; synaptic transmission; intracellular protein transport; cellular protein metabolic process; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; regulation of insulin secretion; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle docking during exocytosis; positive regulation of exocytosis
Reference #:  Q16623 (UniProtKB)
Alt. Names/Synonyms: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A (brain); Syntaxin-1A
Gene Symbols: STX1A
Molecular weight: 33,023 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STX1A

Protein Structure Not Found.


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Sites Implicated In
exocytosis, altered: S14‑p
molecular association, regulation: S14‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T10 DRTQELRTAKDsDDD
0 1 K12 TQELRTAKDsDDDDD
4 17 S14-p ELRTAKDsDDDDDVA
1 0 A21 sDDDDDVAVtVDRDR
0 1 T23-p DDDDVAVtVDRDRFM
0 3 K46 EIRGFIDKIAENVEE
0 3 S59 EEVKRKHSAILAsPN
0 7 S64-p KHSAILAsPNPDEKT
0 1 K70 AsPNPDEKTKEELEE
0 1 S80 EELEELMSDIKKTAN
0 1 K83 EELMSDIKKTANKVR
0 1 K94 NKVRSKLKSIEQSIE
0 3 S95 KVRSKLKSIEQSIEQ
1 1 S162 ITGRTTTSEELEDML
1 0 S188 IIMDSSISKQALSEI
0 1 S249-p DYVERAVsDTKKAVK
0 1 S281-p ILGIVIAstVGGIFA
0 2 T282-p LGIVIAstVGGIFA_
0 1 - gap
  STX1A iso2  
T10 DRTQELRTAKDSDDD
K12 TQELRTAKDSDDDDD
S14 ELRTAKDSDDDDDVA
A21 SDDDDDVAVTVDRDR
T23 DDDDVAVTVDRDRFM
K46 EIRGFIDKIAENVEE
S59 EEVKRKHSAILASPN
S64 KHSAILASPNPDEKT
K70 ASPNPDEKTKEELEE
S80 EELEELMSDIKKTAN
K83 EELMSDIKKTANKVR
K94 NKVRSKLKSIEQSIE
S95 KVRSKLKSIEQSIEQ
S162 ITGRTTTSEELEDML
S188 IIMDSSISKQALSEI
- gap
- gap
- gap
S234-p PQGAFLKsCPEPQPN
  mouse

 
T10-p DRTQELRtAkDsDDD
K12-ub TQELRtAkDsDDDDD
S14-p ELRtAkDsDDDDDVT
T21 sDDDDDVTVTVDRDR
T23 DDDDVTVTVDRDRFM
K46-ub EIRGFIDkIAENVEE
S59-p EEVKRKHsAILAsPN
S64-p KHsAILAsPNPDEkT
K70-ub AsPNPDEkTKEELEE
S80-p EELEELMsDIKKTAN
K83 EELMsDIKKTANKVR
K94-ub NKVRSKLksIEQSIE
S95-p KVRSKLksIEQSIEQ
S162 ITGRTTTSEELEDML
S188 IIMDSSISKQALSEI
S249 DYVERAVSDTKKAVK
S281 ILGIIIASTIGGIFG
T282 LGIIIASTIGGIFG_
- gap
  rat

 
T10 DRTQELRTAKDsDDD
K12 TQELRTAKDsDDDDD
S14-p ELRTAKDsDDDDDVt
T21-p sDDDDDVtVTVDRDR
T23 DDDDVtVTVDRDRFM
K46-ub EIRGFIDkIAENVEE
S59 EEVKRKHSAILAsPN
S64-p KHSAILAsPNPDEKT
K70 AsPNPDEKTKEELEE
S80 EELEELMSDIkKTAN
K83-ac EELMSDIkKTANKVR
K94 NKVRSKLKsIEQSIE
S95-p KVRSKLKsIEQSIEQ
S162-p ITGRTTTsEELEDML
S188-p IIMDSSIsKQALSEI
S249 DYVERAVSDTKKAVK
S281 ILGIIIASTIGGIFG
T282 LGIIIASTIGGIFG_
- gap
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