a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Membrane protein, integral
Molecular Function: protein binding, bridging; SNAP receptor activity; protein domain specific binding; ATP-dependent protein binding; protein binding; SNARE binding; protein heterodimerization activity; myosin head/neck binding; protein N-terminus binding; calcium channel inhibitor activity; glycoprotein binding; calcium-dependent protein binding
Biological Process: synaptic transmission; response to gravity; intracellular protein transport; cellular protein metabolic process; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; regulation of insulin secretion; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle docking during exocytosis; positive regulation of exocytosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.