a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 18.104.22.168; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Src family
Chromosomal Location of Human Ortholog: 20q11-q12
Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; transport vesicle; cell projection; focal adhesion; lysosome; actin filament; caveola; cytosol; nucleus
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; respiratory burst after phagocytosis; viral reproduction; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of phagocytosis; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of cell shape; leukocyte migration during immune response; regulation of transcription factor activity; positive regulation of actin filament polymerization; leukocyte degranulation; regulation of inflammatory response; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; innate immune response; mesoderm development; innate immune response-activating signal transduction; inflammatory response; cell adhesion; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.