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Protein Page:
Hck (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Hck a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Src family
Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; transport vesicle; cell projection; focal adhesion; lysosome; actin filament; caveola; nucleus; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; respiratory burst after phagocytosis; viral reproduction; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of phagocytosis; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of cell shape; leukocyte migration during immune response; positive regulation of actin filament polymerization; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; regulation of inflammatory response; lipopolysaccharide-mediated signaling pathway; innate immune response; mesoderm development; cell adhesion; innate immune response-activating signal transduction; inflammatory response; negative regulation of apoptosis
Reference #:  P08631 (UniProtKB)
Alt. Names/Synonyms: HCK; Hemopoietic cell kinase; JTK9; p59-HCK/p60-HCK; Tyrosine-protein kinase HCK
Gene Symbols: HCK
Molecular weight: 59,600 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Hck

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y522‑p
activity, inhibited: Y522‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K28-ub RMGCMKSkFLQVGGN
0 1 N35 kFLQVGGNtFSKTET
0 2 T36-p FLQVGGNtFSKTETS
1 74 Y51-p ASPHCPVyVPDPTST
0 1 Y87 DIIVVALYDyEAIHH
0 2 Y89-p IVVALYDyEAIHHED
0 1 K124-ub ARSLATRkEGyIPSN
0 1 Y127-p LATRkEGyIPSNYVA
0 1 Y180-p SETTKGSySLSVRDY
0 1 T202-p VKHYKIRtLDNGGFy
0 424 Y209-p tLDNGGFyISPRSTF
0 1 K228-ac ELVDHYKkGNDGLCQ
0 1 S238-p DGLCQKLsVPCMSSK
0 1 K283-ub VWMATYNkHTkVAVK
0 1 K286-ub ATYNkHTkVAVKTMK
0 1 T311-p AEANVMKtLQHDKLV
0 7 Y330-p VVTKEPIyIITEFMA
3 2105 Y411-p RVIEDNEytAREGAK
0 12 T412-p VIEDNEytAREGAKF
0 1 S442-p TIKSDVWsFGILLME
0 1 S462-p RIPYPGMsNPEVIRA
0 7 S520-p DFYTATEsQyQQQP_
3 326 Y522-p YTATEsQyQQQP___
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  mouse

 
R28 RMGCVKSRFLRDGsK
S34-p SRFLRDGsKASKTEP
A36 FLRDGsKASKTEPSA
Y50-p ANQKGPVyVPDPTSS
Y85-p DTIVVALyDYEAIHR
Y87 IVVALyDYEAIHRED
K122 ARSLATKKEGYIPSN
Y125 LATKKEGYIPSNYVA
Y178 SETTKGSYSLSVRDF
T200-p VKHYKIRtLDSGGFy
Y207-p tLDSGGFyISPRSTF
K226 ELVLHYKKGKDGLCQ
S236 DGLCQKLSVPCVSPK
K281 VWMATYNKHTKVAVK
K284 ATYNKHTKVAVKTMK
S309 AEANLMKSLQHDKLV
F328 VVSQEPIFIVTEFMA
Y409-p RIIEDNEytAREGAK
T410-p IIEDNEytAREGAKF
S440 TIKSDVWSFGILLME
S460 RIPYPGMSNPEVIRA
S518 DFYTATESQyQQQP_
Y520-p YTATESQyQQQP___
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  rat

 
R28 RMGCVKSRFLREGSK
S34 SRFLREGSKASKIEP
A36 FLREGSKASKIEPNA
Y50 ANQKGPVYVPDPTSP
Y85 DTIVVALYDYEAIHR
Y87 IVVALYDYEAIHRED
K122 ARSLATKKEGYIPSN
Y125 LATKKEGYIPSNYVA
Y178 SETTKGSYSLSVRDF
T200 VKHYKIRTLDSGGFy
Y207-p TLDSGGFyISPRSTF
K226 ELVVHYKKGKDGLCQ
S236 DGLCQKLSVPCVSPK
K281 VWMATYNKHTKVAVK
K284 ATYNKHTKVAVKTMK
T309 AEANLMKTLQHDKLV
F328 VVSQEPIFIVTEFMA
Y409-p RIIEDNEytAREGAK
T410-p IIEDNEytAREGAKF
S440 TIKSDVWSFGILLME
S460 RIPYPGMSNPEVIRA
S518 DFYTATESQYQQQP_
Y520 YTATESQYQQQP___
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