a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 188.8.131.52; TK group; Src family
Chromosomal Location of Human Ortholog: 20q11-q12
Cellular Component: Golgi apparatus; transport vesicle; extrinsic to internal side of plasma membrane; cell projection; focal adhesion; lysosome; actin filament; caveola; cytosol; nucleus
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: integrin-mediated signaling pathway; respiratory burst after phagocytosis; peptidyl-tyrosine phosphorylation; viral reproduction; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of cell shape; leukocyte migration during immune response; positive regulation of actin filament polymerization; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; regulation of inflammatory response; lipopolysaccharide-mediated signaling pathway; innate immune response; mesoderm development; innate immune response-activating signal transduction; cell adhesion; inflammatory response; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.