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Protein Page:
MCPH1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MCPH1 a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center
Molecular Function: identical protein binding; protein binding
Biological Process: mitotic cell cycle
Reference #:  Q8NEM0 (UniProtKB)
Alt. Names/Synonyms: BRCT-repeat inhibitor of TERT expression 1; BRIT1; FLJ12847; MCPH1; MCT; Microcephalin; microcephalin 1
Gene Symbols: MCPH1
Molecular weight: 92,877 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCPH1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T120-p PKDFNFKtPENDKRF
0 6 T143-p KELQRQKtNLDDDVP
0 2 S156 VPILLFESNGSLIYT
0 3 - gap
0 1 - gap
0 1 S277 KANNIHSSPsFTHLD
0 2 S279-p NNIHSSPsFTHLDKS
0 1 S287-p FTHLDKSsPQKFLSN
0 1 N294 sPQKFLSNLSKEEIN
0 1 S296 QKFLSNLSKEEINLQ
0 3 S333-p FEEKYRLsPtLsSTK
0 2 T335-p EKYRLsPtLsSTKGH
0 2 S337-p YRLsPtLsSTKGHLL
0 3 K370 SHSPPKEKCKRKRST
0 1 S526 CPEGNGFSYTIEDPA
0 1 Y527 PEGNGFSYTIEDPAL
0 1 - gap
0 2 S548-p DLTPLEGsLEEMKEA
0 2 Y606-p KENLPGGySGSVKNR
0 2 R642 EELKKSGRGKKPTRT
  MCPH1 iso3  
T120 PKDFNFKTPENDKRF
T143-p KELQRQKtNLDDDVP
S156 VPILLFESNGSLIYT
- gap
- gap
S277 KANNIHSSPSFTHLD
S279 NNIHSSPSFTHLDKS
S287 FTHLDKSSPQKFLSN
N294 SPQKFLSNLSKEEIN
S296 QKFLSNLSKEEINLQ
S333 FEEKYRLSPTLSSTK
T335 EKYRLSPTLSSTKGH
S337 YRLSPTLSSTKGHLL
K370 SHSPPKEKCKRKRST
S526 CPEGNGFSYTIEDPA
Y527 PEGNGFSYTIEDPAL
- gap
S548 DLTPLEGSLEEMKEA
Y606-p KENLPGGySGSM___
- gap
  mouse

 
T126 PKDFILKTPENDKRL
A149 EELQRQKAALDDDVP
S162-p VPVLLFEsPRSLVYS
S170-p PRSLVYSsPVNVMKR
S267-p SPVLRASsFYGsAsP
S271-p RASsFYGsAsPNHLR
S273-p SsFYGsAsPNHLRQP
- gap
S288-p RPQKAPDsPsKESIN
S290-p QKAPDsPsKESINCQ
S327-p PDEKLCLsPtMsIIE
T329-p EKLCLsPtMsIIEEH
S331-p LCLsPtMsIIEEHQV
K360-a ADLGSSPkGKLKKRY
S520-p DDTGPEGssHPDTLS
S521-p DTGPEGssHPDTLSS
S529-p HPDTLSSsAHHITPL
S540 ITPLKGNSTETRDPG
Y596 KENIATGYSESVKNG
K629-a QKPKKSEkEEKPTRT
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