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Protein Page:
STX16 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STX16 SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B). Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Belongs to the syntaxin family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein
Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; integral to membrane; nucleolus
Molecular Function: SNAP receptor activity; protein binding
Biological Process: intra-Golgi vesicle-mediated transport; intracellular protein transport; retrograde transport, endosome to Golgi
Reference #:  O14662 (UniProtKB)
Alt. Names/Synonyms: hsyn16; MGC90328; STX16; Syn16; syntaxin 16; Syntaxin-16
Gene Symbols: STX16
Molecular weight: 37,031 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Select Structure to View Below

STX16

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 13 T7-p _MATRRLtDAFLLLR
0 2 S17-p FLLLRNNsIQNRQLL
0 1 S29 QLLAEQVSSHITSsP
0 1 S34 QVSSHITSsPLHSRs
0 4 S35-p VSSHITSsPLHSRsI
0 7 S41-p SsPLHSRsIAAELDE
0 2 T71-p PEAAIGVtKRPPPKW
0 4 P74 AIGVtKRPPPKWVDG
0 1 K77 VtKRPPPKWVDGVDE
0 14 Y87-p DGVDEIQyDVGRIKQ
0 1 K97-m1 GRIKQKMkELASLHD
0 1 T200-p RSQHFFDtSVPLMDD
0 1 T212-p MDDGDDNtLyHRGFT
0 63 Y214-p DGDDNtLyHRGFTED
0 1 K301-ub QYQKKNRkMLVILIL
  STX16 iso5  
T7 _MATRRLTDAFLLLR
S17 FLLLRNNSIQNRQLL
S29 QLLAEQVSSHITSSP
S34 QVSSHITSSPLHSRs
S35 VSSHITSSPLHSRsI
S41-p SSPLHSRsIAALADD
T67-p PEAAIGVtKRPPPKW
P70 AIGVtKRPPPKWVDG
K73 VtKRPPPKWVDGVDE
Y83 DGVDEIQYDVGRIKQ
K93 GRIKQKMKELASLHD
T196 RSQHFFDTSVPLMDD
T208 MDDGDDNTLYHRGFT
Y210 DGDDNTLYHRGFTED
K297 QYQKKNRKMLVILIL
  mouse

 
T7-p _MATRRLtDAFLLLR
S17 FLLLRNNSIQTRQLL
S29-p QLLAEQVsSHTTssP
S34-p QVsSHTTssPLHSRs
S35-p VsSHTTssPLHSRsI
S41-p ssPLHSRsIAAELDE
T71-p PEAAIGVtKRsPPkW
S74-p AIGVtKRsPPkWVDG
K77-ub VtKRsPPkWVDGVDE
Y87-p DGVDEIQyDVGRIKQ
K97 GRIKQKMKELASLHD
T201 RSQHFFDTPVPLMDD
T213 MDDGDDATLYGQGFT
Y215 DGDDATLYGQGFTDD
K302 QYQKKNRKMLVIVIL
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