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FZD5 (human)

Overview FZD5 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, Fz/Smo family Cellular Component: Golgi membrane; cell surface; cell projection; cytoplasm; plasma membrane; integral to membrane Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; protein kinase binding; PDZ domain binding Biological Process: positive regulation of JNK activity; post-embryonic camera-type eye development; gonad development; apoptosis; embryonic axis specification; cell maturation; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; embryonic camera-type eye development; neuron differentiation; negative regulation of cell proliferation; positive regulation of interferon-gamma production; axonogenesis; determination of anterior/posterior axis, embryo; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; brain development; Spemann organizer formation Reference #:  Q13467 (UniProtKB) Alt. Names/Synonyms: C2orf31; DKFZp434E2135; frizzled homolog 5 (Drosophila); Frizzled-5; Fz-5; FZD5; FzE5; hFz5; MGC129692; seven-transmembrane receptor frizzled-5; Wnt receptor Gene Symbols: FZD5 Molecular weight: 64,507 Da Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FZD5

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S11-p	PDPsAPPsLLLLLLA
0	1		S7-p	_MARPDPsAPPsLLL
0	1		T440-p	IKQGGTKtDKLEKLM
0	1		Y500	QPRAKPEYWVLMLKY
0	5		Y556-p	GAMAAGDyPEASAAL
0	6		T575-p	GPPGPAAtyHKQVSL
0	15		Y576-p	PPGPAAtyHKQVSLS

	mouse
S11	PDPSAPPSLLLLLLA
S7	_MARPDPSAPPSLLL
T440	IKQGGTKTDKLEKLM
Y500	QPRAKPEYWVLMLKY
Y556	GAMAAGDYAEASAAL
A575	GPPGPTAAYHKQVSL
Y576	PPGPTAAYHKQVSLS

	rat
S11	PDPSAPPSLLLLLLA
S7	_MARPDPSAPPSLLL
T440	IKQGGTKTDKLEKLM
Y500-p	QPRAKPEyWVLMLKY
Y556	GAMVAGDYAEASAAL
A575	GPPGPAAAYHKQVSL
Y576	PPGPAAAYHKQVSLS

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