Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
FZD5 (human)

Overview
FZD5 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB.
Protein type: GPCR, Fz/Smo family; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: Golgi membrane; cell surface; cell projection; perinuclear region of cytoplasm; cytoplasm; early endosome; integral to membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; protein kinase binding; PDZ domain binding
Biological Process: positive regulation of JNK activity; post-embryonic camera-type eye development; gonad development; apoptosis; cell maturation; embryonic axis specification; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; embryonic camera-type eye development; neuron differentiation; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; positive regulation of interferon-gamma production; axonogenesis; determination of anterior/posterior axis, embryo; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; brain development; Spemann organizer formation
Reference #:  Q13467 (UniProtKB)
Alt. Names/Synonyms: C2orf31; DKFZp434E2135; frizzled homolog 5 (Drosophila); Frizzled-5; Fz-5; FZD5; FzE5; hFz5; MGC129692; seven-transmembrane receptor frizzled-5; Wnt receptor
Gene Symbols: FZD5
Molecular weight: 64,507 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FZD5

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MARPDPsAPPsLLL
0 1 S11-p PDPsAPPsLLLLLLA
0 1 T440-p IKQGGTKtDKLEKLM
0 5 Y556-p GAMAAGDyPEASAAL
0 6 T575-p GPPGPAAtyHKQVSL
0 17 Y576-p PPGPAAtyHKQVSLS
  mouse

 
S7 _MARPDPSAPPSLLL
S11 PDPSAPPSLLLLLLA
T440 IKQGGTKTDKLEKLM
Y556 GAMAAGDYAEASAAL
A575 GPPGPTAAYHKQVSL
Y576 PPGPTAAYHKQVSLS
  rat

 
S7 _MARPDPSAPPSLLL
S11 PDPSAPPSLLLLLLA
T440 IKQGGTKTDKLEKLM
Y556 GAMVAGDYAEASAAL
A575 GPPGPAAAYHKQVSL
Y576 PPGPAAAYHKQVSLS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.