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Protein Page:
CSK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CSK a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.2; TK group; Csk family
Cellular Component: cytoplasm; plasma membrane; intercellular junction; cytosol; lipid raft
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; platelet activation; negative regulation of phagocytosis; peptidyl-tyrosine phosphorylation; negative regulation of Golgi to plasma membrane protein transport; protein amino acid autophosphorylation; T cell receptor signaling pathway; protein amino acid phosphorylation; negative regulation of cell proliferation; positive regulation of MAP kinase activity; T cell costimulation; negative regulation of interleukin-6 production; oligodendrocyte differentiation; brain development; blood coagulation; negative regulation of bone resorption
Reference #:  P41240 (UniProtKB)
Alt. Names/Synonyms: C-Src kinase; c-src tyrosine kinase; CSK; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
Gene Symbols: CSK
Molecular weight: 50,704 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CSK

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S364‑p
phosphorylation: S364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K43-ub LTIVAVTkDPNWYKA
0 6 Y64-p EGIIPANyVQKREGV
0 2 Y97-p EQAERLLyPPETGLF
0 1 K171-ub CTRLIKPkVMEGTVA
1 38 Y184-p VAAQDEFyRsGWALN
0 1 S186-p AQDEFyRsGWALNMk
0 2 K193-ub sGWALNMkELkLLQT
0 2 K196-ub ALNMkELkLLQTIGk
0 6 K203-ub kLLQTIGkGEFGDVM
0 7 K222-ub RGNKVAVkCIKNDAT
0 1 Y263-p VEEKGGLyIVTEYMA
0 6 Y277-p AKGSLVDyLRSRGRs
0 2 S284-p yLRSRGRsVLGGDCL
0 1 K329-ub VSEDNVAkVSDFGLT
0 1 K337-ub VSDFGLTkEASSTQD
0 1 K347-ub SSTQDTGkLPVKWTA
3 0 S364-p ALREKKFsTKSDVWS
0 3 K393-ub PYPRIPLkDVVPRVE
0 1 Y416-p DGCPPAVyEVMKNCW
  mouse

 
K43 LTIVAVTKDPNWYKA
Y64 EGIIPANYVQKREGV
Y97-p EQAERLLyPPETGLF
K171 CTRLIKPKVMEGTVA
Y184-p VAAQDEFyRSGWALN
S186 AQDEFyRSGWALNMK
K193 SGWALNMKELKLLQT
K196 ALNMKELKLLQTIGK
K203 KLLQTIGKGEFGDVM
K222 RGNKVAVKCIKNDAT
Y263 VEEKGGLYIVTEYMA
Y277 AKGSLVDYLRSRGRS
S284 YLRSRGRSVLGGDCL
K329 VSEDNVAKVSDFGLT
K337 VSDFGLTKEASSTQD
K347 SSTQDTGKLPVKWTA
S364 ALREKKFSTKSDVWS
K393 PYPRIPLKDVVPRVE
Y416 DGCPPAVYEVMKNCW
  rat

 
K43 LTIVAVTKDPNWYKA
Y64 EGIIPANYVQKREGV
Y97 EQAERLLYPPETGLF
K171 CTRLIKPKVMEGTVA
Y184 VAAQDEFYRSGWALN
S186 AQDEFYRSGWALNMK
K193 SGWALNMKELKLLQT
K196 ALNMKELKLLQTIGK
K203 KLLQTIGKGEFGDVM
K222 RGNKVAVKCIKNDAT
Y263 VEEKGGLYIVTEYMA
Y277 AKGSLVDYLRSRGRS
S284 YLRSRGRSVLGGDCL
K329 VSEDNVAKVSDFGLT
K337 VSDFGLTKEASSTQD
K347 SSTQDTGKLPVKWTA
S364 ALREKKFSTKSDVWS
K393 PYPRIPLKDVVPRVE
Y416 DGCPPAVYDVMKNCW
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