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CSK (human)

Overview CSK a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.2; TK group; Csk family Cellular Component: Golgi apparatus; centrosome; intracellular membrane-bound organelle; cytoplasm; plasma membrane; intercellular junction; cytosol Molecular Function: protein C-terminus binding; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; negative regulation of cell proliferation; negative regulation of Golgi to plasma membrane protein transport; T cell costimulation; blood coagulation; protein amino acid phosphorylation; T cell receptor signaling pathway Reference #:  P41240 (UniProtKB) Alt. Names/Synonyms: C-Src kinase; c-src tyrosine kinase; CSK; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK Gene Symbols: CSK Molecular weight: 50,704 Da Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CSK 1BYG - A=173-450 (human) 1CSK - A/B/C/D=1-71 (human) 3D7T - A=188-450 (human) 3D7U - A/C=188-450 (human) 3EAC - A=73-178 (human) 3EAZ - A=73-178 (human) 1JEG - A=1-83 (mouse) 1K9A - A/B/C/D/E/F=1-450 (rat) 2RSY - B=288-321 (rat)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S364‑p phosphorylation: S364‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K43-u	LTIVAVTkDPNWYKA
0	5		Y64-p	EGIIPANyVQKREGV
0	2		Y97-p	EQAERLLyPPETGLF
0	1		K171-u	CTRLIKPkVMEGTVA
1	40		Y184-p	VAAQDEFyRsGWALN
0	1		S186-p	AQDEFyRsGWALNMk
0	2		K193-u	sGWALNMkELkLLQT
0	2		K196-u	ALNMkELkLLQTIGk
0	6		K203-u	kLLQTIGkGEFGDVM
0	7		K222-u	RGNKVAVkCIKNDAT
0	1		Y263-p	VEEKGGLyIVTEYMA
0	4		Y277-p	AKGSLVDyLRSRGRs
0	2		S284-p	yLRSRGRsVLGGDCL
0	1		K329-u	VSEDNVAkVSDFGLT
0	1		K337-u	VSDFGLTkEASSTQD
0	1		K347-u	SSTQDTGkLPVKWTA
3	0		S364-p	ALREKKFsTKSDVWS
0	3		K393-u	PYPRIPLkDVVPRVE
0	1		Y416-p	DGCPPAVyEVMKNCW

	mouse
K43	LTIVAVTKDPNWYKA
Y64	EGIIPANYVQKREGV
Y97-p	EQAERLLyPPETGLF
K171	CTRLIKPKVMEGTVA
Y184-p	VAAQDEFyRSGWALN
S186	AQDEFyRSGWALNMK
K193	SGWALNMKELKLLQT
K196	ALNMKELKLLQTIGK
K203	KLLQTIGKGEFGDVM
K222	RGNKVAVKCIKNDAT
Y263	VEEKGGLYIVTEYMA
Y277	AKGSLVDYLRSRGRS
S284	YLRSRGRSVLGGDCL
K329	VSEDNVAKVSDFGLT
K337	VSDFGLTKEASSTQD
K347	SSTQDTGKLPVKWTA
S364	ALREKKFSTKSDVWS
K393	PYPRIPLKDVVPRVE
Y416	DGCPPAVYEVMKNCW

	rat
K43	LTIVAVTKDPNWYKA
Y64	EGIIPANYVQKREGV
Y97	EQAERLLYPPETGLF
K171	CTRLIKPKVMEGTVA
Y184	VAAQDEFYRSGWALN
S186	AQDEFYRSGWALNMK
K193	SGWALNMKELKLLQT
K196	ALNMKELKLLQTIGK
K203	KLLQTIGKGEFGDVM
K222	RGNKVAVKCIKNDAT
Y263	VEEKGGLYIVTEYMA
Y277	AKGSLVDYLRSRGRS
S284	YLRSRGRSVLGGDCL
K329	VSEDNVAKVSDFGLT
K337	VSDFGLTKEASSTQD
K347	SSTQDTGKLPVKWTA
S364	ALREKKFSTKSDVWS
K393	PYPRIPLKDVVPRVE
Y416	DGCPPAVYDVMKNCW

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