May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. Note: This description may include information from UniProtKB.
Cellular Component: asymmetric synapse; filopodium membrane; cytoskeleton; protein complex; cell soma; perinuclear region of cytoplasm; basolateral plasma membrane; postsynaptic density; plasma membrane; dendritic spine; dendritic shaft; cytosol
Molecular Function: calmodulin binding; protein domain specific binding; protein binding; G-protein-coupled receptor binding; cadherin binding; protein kinase A binding; protein complex binding; GABA receptor binding; actin binding; protein kinase binding; adenylate cyclase binding; protein phosphatase 2B binding
Biological Process: response to muscle activity; maternal process involved in pregnancy; cellular protein complex disassembly; positive regulation of NFAT protein import into nucleus; negative regulation of potassium ion transport; negative regulation of adenylate cyclase activity; hippocampus development; positive regulation of dendrite morphogenesis; signal transduction; synaptic transmission; spinal cord development; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of adenylate cyclase activity; response to electrical stimulus; regulation of insulin secretion; protein targeting
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; AKAP 79; AKAP-5; AKAP5; AKAP75; AKAP79; cAMP-dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.