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Protein Page:
AKAP5 (human)

Overview
AKAP5 May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: plasma membrane; cytosol
Molecular Function: calmodulin binding; protein binding; protein kinase A binding; adenylate cyclase binding
Biological Process: synaptic transmission; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; signal transduction; regulation of insulin secretion; protein targeting
Reference #:  P24588 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; AKAP 79; AKAP-5; AKAP5; AKAP75; AKAP79; cAMP-dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21
Gene Symbols: AKAP5
Molecular weight: 47,088 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AKAP5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T4 ____METTISEIHVE
0 2 S6 __METTISEIHVENK
0 1 S18-p ENKDEKRsAEGsPGA
0 4 S22-p EKRsAEGsPGAERQK
0 2 S53-p ALKPKAGsEAADVAR
0 1 S92-p LVTRRKRsESsKQQK
0 1 S95-p RRKRsESsKQQKPLE
0 1 S148 HSKIIEDSDCSIKVQ
0 3 S178-p DQATKAKsTQDLSEG
0 5 T227 HSAIQTGTLILEEIE
0 5 S248 DVQPQQASPLETSET
0 5 H257 LETSETDHQQPVLSD
0 3 - gap
  AKAP5 iso2  
T4 ____METTISEIHVE
S6 __METTISEIHVENK
S18 ENKDEKRSAEGSPGA
S22 EKRSAEGSPGAERQK
S53 ALKPKAGSEAADVAR
S92 LVTRRKRSESSKQQK
S95 RRKRSESSKQQKPLE
S148 HSKIIEDSDCSIKVQ
S178 DQATKAKSTQDLSEG
T227 HSAIQTGTLILEEIE
S248 DVQPQQASPLETSET
H257 LETSETDHQQPVLSD
- gap
  mouse

 
S4-p ____METsVsEIQVE
S6-p __METsVsEIQVETK
P18 ETKDEKGPVAAsPQK
S22-p EKGPVAAsPQKERQE
S52 KTKPKAGSRTAEETK
S90 LVTHRKRSEPAKKQK
A93 HRKRSEPAKKQKPPE
S142-p HSKLTEDsGYVRVQG
S171 DQAIQAGSTQGLQEG
T220-p SSAIQMGtPELEKET
S242-p SVQTQRAsLLESSAA
S251-p LESSAAGsPRSVTSA
S349-p QAKEGKLsQAEETTV
  rat

 
S4 ____METSVSEIQIE
S6 __METSVSEIQIETK
P18 ETKDEKRPEAASPQK
S22 EKRPEAASPQKERQE
S52 KKKAKAGSKTAEETE
S90 LVTHRKPSESAEKQK
A93 HRKPSESAEKQKPSE
S142 PSKLTEDSGYVRVQG
S171 EQATQAKSTQGLQED
T220 SSALRMRTPGSEKEA
S242 GVQVQEASVLENSAA
S251 LENSAADSPQPVTST
S351 QAKEGKLSQAEEATV
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