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FGF1 (human)

Overview FGF1 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Cytokine Cellular Component: proteinaceous extracellular matrix; extracellular space; nucleolus; extracellular region; cell cortex; cytosol Molecular Function: heparin binding; protein binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: nervous system development; anatomical structure morphogenesis; positive regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; multicellular organismal development; protein kinase cascade; positive regulation of cholesterol biosynthetic process; signal transduction; positive regulation of angiogenesis; induction of an organ; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of epithelial cell proliferation; lung development; positive regulation of cell migration Reference #:  P05230 (UniProtKB) Alt. Names/Synonyms: Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF; ECGF-beta; ECGFA; ECGFB; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; FGF-alpha; FGF1; FGFA; fibroblast growth factor 1 (acidic); GLIO703; HBGF-1; HBGF1; Heparin-binding growth factor 1 Gene Symbols: FGF1 Molecular weight: 17,460 Da Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FGF1 1AXM - A/B/C/D/E/F=21-155 (human) 1DJS - B=21-155 (human) 1DZC - A=28-155 (human) 1DZD - A=29-155 (human) 1E0O - A/C=16-155 (human) 1EVT - A/B=22-155 (human) 1HKN - A/B/C/D/E/F=17-155 (human) 1JQZ - A/B=16-155 (human) 1JT3 - A/B=16-155 (human) 1JT4 - A/B=16-155 (human) 1JT5 - A/B=16-155 (human) 1JT7 - A/B/C/D=16-155 (human) 1JTC - A/B/C/D=16-155 (human) 1JY0 - A/B=16-155 (human) 1K5U - A/B/C=16-155 (human) 1K5V - A/B=16-155 (human) 1M16 - A/B=16-155 (human) 1NZK - A/B/C/D=16-152 (human) 1P63 - A/B=16-155 (human) 1PZZ - A/B=16-155 (human) 1Q03 - A/B=16-155 (human) 1Q04 - A/B=16-155 (human) 1QCT - A/D=24-153 (human) 1RG8 - A/B=16-155 (human) 1RML - A=1-155 (human) 1RY7 - A=1-155 (human) 1YTO - A/B/C/D=16-155 (human) 1Z2V - A/B=16-155 (human) 1Z4S - A/B/C/D=16-155 (human) 2AFG - A/B/C/D=16-155 (human) 2AQZ - A/B=16-155 (human) 2AXM - A/B=21-155 (human) 2ERM - B=17-155 (human) 2HW9 - A/B=16-155 (human) 2HWA - A/B=16-155 (human) 2HWM - A/B=16-155 (human) 2HZ9 - A/B=16-155 (human) 2K43 - A=23-155 (human) 2K4A - B=23-155 (human) 2K8R - A=23-155 (human) 2KI4 - A/D=23-155 (human) 2KI6 - E/B=23-155 (human) 2LDN - A=23-152 (human) 2NTD - A/B/C/D=16-155 (human) 2Q9X - A=16-155 (human) 2RQ9 - A=22-155 (human) 3B9U - A=16-155 (human) 3BA4 - A/B=16-155 (human) 3BA5 - A/B=16-155 (human) 3BA7 - A/B=16-155 (human) 3BAD - A/B=16-155 (human) 3BAG - A/B=16-155 (human) 3BAH - A/B=16-155 (human) 3BAO - A/B=16-155 (human) 3BAQ - A/B=16-155 (human) 3BAU - A/B=16-155 (human) 3BAV - A/B=16-155 (human) 3BB2 - A/B=16-155 (human) 3CQA - A/B=16-155 (human) 3CRG - A/B=16-155 (human) 3CRH - A/B=16-155 (human) 3CRI - A/B=16-155 (human) 3CU1 - D/B=22-152 (human) 3FJ8 - A/B=16-155 (human) 3FJ9 - A/B=16-155 (human) 3FJA - A/B=16-155 (human) 3FJB - A/B=16-155 (human) 3FJC - A/B=16-155 (human) 3FJD - A/B=16-155 (human) 3FJE - A/B=16-155 (human) 3FJF - A/B=16-155 (human) 3FJH - A/B=16-155 (human) 3FJI - A/D/C/B=16-155 (human) 3FJJ - A/B=16-155 (human) 3FJK - A/D/C/B=16-155 (human) 3HOM - A/B=16-155 (human) 3JUT - F/A/D/C/E/B=24-153 (human) 3K1X - F/A/D/C/E/B=24-153 (human) 3O3Q - A/D/C/B=16-155 (human) 3OJ2 - A/B=1-155 (human) 3OJM - A=1-155 (human) 3OJV - A/B=21-155 (human) 3UD7 - A/C/B=16-155 (human) 3UD8 - A/C/B=16-155 (human) 3UD9 - A/C/B=16-155 (human) 3UDA - A/C/B=16-155 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2LDN 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T45	LRILPDGTVDGTRDR
0	1		S62	QHIQLQLSAESVGEV
0	1		S65	QLQLSAESVGEVYIK
0	1		S153	LFLPLPVSSD_____

	FGF1 iso2
T45-p	LRILPDGtVDGTRDR
-	gap
-	gap
-	gap

	mouse
T45	LRILPDGTVDGTRDR
S62-p	QHIQLQLsAEsAGEV
S65-p	QLQLsAEsAGEVYIK
S153-p	LFLPLPVsSD_____

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