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Protein Page:
FGF1 (human)

Overview
FGF1 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytokine; Cell development/differentiation
Cellular Component: proteinaceous extracellular matrix; extracellular space; nucleolus; extracellular region; cell cortex; nucleus; cytosol
Molecular Function: heparin binding; protein binding; growth factor activity; Hsp70 protein binding; fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; multicellular organismal development; positive regulation of cholesterol biosynthetic process; signal transduction; positive regulation of angiogenesis; induction of an organ; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of epithelial cell proliferation; lung development; positive regulation of cell migration
Reference #:  P05230 (UniProtKB)
Alt. Names/Synonyms: Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF; ECGF-beta; ECGFA; ECGFB; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; FGF-alpha; FGF1; FGFA; fibroblast growth factor 1 (acidic); GLIO703; HBGF-1; HBGF1; Heparin-binding growth factor 1
Gene Symbols: FGF1
Molecular weight: 17,460 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGF1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T45 LRILPDGTVDGTRDR
0 1 S62 QHIQLQLSAESVGEV
0 1 S65 QLQLSAESVGEVYIK
1 0 S131-p VGLKKNGsCKRGPRT
0 1 S153 LFLPLPVSSD_____
  FGF1 iso2  
T45-p LRILPDGtVDGTRDR
- gap
- gap
- gap
- gap
  mouse

 
T45 LRILPDGTVDGTRDR
S62-p QHIQLQLsAEsAGEV
S65-p QLQLsAEsAGEVYIK
S131 VGLKKNGSCKRGPRT
S153-p LFLPLPVsSD_____
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