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Protein Page:
SAV1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SAV1 Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA. Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding
Biological Process: keratinocyte differentiation; hair follicle development; positive regulation of apoptosis; negative regulation of cardiac muscle cell proliferation; negative regulation of epithelial cell proliferation
Reference #:  Q9H4B6 (UniProtKB)
Alt. Names/Synonyms: 1700040G09Rik; 45 kDa WW domain protein; hWW45; Protein salvador homolog 1; salvador homolog 1 (Drosophila); SAV; SAV1; WW domain-containing; WW45; WWP4
Gene Symbols: SAV1
Molecular weight: 44,634 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SAV1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: T26‑p, S27‑p, S36‑p, S269‑p
protein conformation: T26‑p, S27‑p, S36‑p, S269‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T26-p GKYVKKEtsPLLRNL
0 3 S27-p KYVKKEtsPLLRNLM
0 1 S36-p LLRNLMPsFIRHGPT
0 1 S56-p DICLPDSsPNAFSTS
0 1 S72-p DVVSRNQsFLrtPIQ
0 1 R75-m1 SRNQsFLrtPIQRTP
0 1 T76-p RNQsFLrtPIQRTPH
0 2 S90-p HEIMRREsNRLsAPS
0 4 S94-p RREsNRLsAPSYLAR
0 1 S102 APSYLARSLADVPRE
0 1 Y135-p DSGSRYYysDNFFDG
0 2 S136-p SGSRYYysDNFFDGQ
0 1 Y158-p RAHEDYRyYEYNHDL
0 1 S206-p LPLPPGWsVDWtMRG
0 6 T210-p PGWsVDWtMRGRKYY
0 1 Y357-p IVKMYEAyRQALLTE
  mouse

 
T26 GKYVKKETSPLLRNL
S27 KYVKKETSPLLRNLM
S36 LLRNLMPSFIRHGPT
S56 DLCLPDSSATAFSAS
S73 GVVSRNQSFLRTAIQ
R76 SRNQSFLRTAIQRTP
T77 RNQSFLRTAIQRTPH
S91 HEVMRRESHRLsAPS
S95-p RRESHRLsAPSYLVR
S103-p APSYLVRsLADVPRE
F136 DSGSRYFFsDNFFDG
S137-p SGSRYFFsDNFFDGQ
Y159 RAQEDYRYYEYNHDL
S207 LPLPPGWSVDWTMRG
T211 PGWSVDWTMRGRKYY
Y358 IVKLYEAYRQALLTE
  rat

 
T26 GKYVKKETSPLLRNL
S27 KYVKKETSPLLRNLM
S36 LLRNLMPSFIRHGPT
S56 DLCLPESSASAFSAS
S73 GVVSRNQSFLRTPVQ
R76 SRNQSFLRTPVQRTP
T77 RNQSFLRTPVQRTPH
S91 HEVMRRESNRLSAPS
S95 RRESNRLSAPSSYLV
S104 PSSYLVRSLADVPRE
Y137 DSGSRYFYSDNFFDG
S138 SGSRYFYSDNFFDGQ
Y160 RAQEDYRYYEYNHDL
S208 LPLPPGWSVDWTMRG
T212 PGWSVDWTMRGRKYY
Y359 IVKLYEAYRQALVTE
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