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Protein Page:
CD10 (human)

Overview
CD10 Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 3.4.24.11; Protease
Cellular Component: synaptic vesicle; axon; integral to plasma membrane; cytoplasm; dendrite; plasma membrane; integral to membrane; synapse; brush border
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity; peptide binding
Biological Process: peptide metabolic process; cellular protein metabolic process; beta-amyloid metabolic process; creatinine metabolic process; kidney development; sensory perception of pain; proteolysis; angiotensin maturation
Reference #:  P08473 (UniProtKB)
Alt. Names/Synonyms: Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; Enkephalinase; EPN; membrane metallo-endopeptidase; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11
Gene Symbols: MME
Molecular weight: 85,514 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD10

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S6‑p
phosphorylation: S6‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 3 S4-p ____MGKsEsQMDIt
2 16 S6-p __MGKsEsQMDItDI
1 0 T11-p sEsQMDItDINtPKP
0 2 T15-p MDItDINtPKPKKKQ
0 2 Y387-p VSSLSRTyKESRNAF
  mouse

 
S4-p ____MGRsEsQMDIt
S6-p __MGRsEsQMDItDI
T11-p sEsQMDItDINAPKP
A15 MDItDINAPKPKKKQ
Y387 VSSLSRNYKESRNAF
  rat

 
S4 ____MGRSESQMDIT
S6 __MGRSESQMDITDI
T11 SESQMDITDINAPKP
A15 MDITDINAPKPKKKQ
Y387 VSSLSRNYKESRNAF
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