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Protein Page:
CD10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD10 Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.24.11; Membrane protein, integral
Cellular Component: synaptic vesicle; axon; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; integral to membrane; synapse; brush border
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity; peptide binding
Biological Process: peptide metabolic process; cellular protein metabolic process; beta-amyloid metabolic process; creatinine metabolic process; kidney development; angiotensin maturation; proteolysis; sensory perception of pain
Reference #:  P08473 (UniProtKB)
Alt. Names/Synonyms: Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; Enkephalinase; EPN; membrane metallo-endopeptidase; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11
Gene Symbols: MME
Molecular weight: 85,514 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD10

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S6‑p
phosphorylation: S6‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 6 S4-p ____MGKsEsQMDIt
2 20 S6-p __MGKsEsQMDItDI
1 2 T11-p sEsQMDItDINtPKP
0 3 T15-p MDItDINtPKPKKKQ
0 1 K85-ac EPCTDFFkYACGGWL
0 1 K93-ac YACGGWLkRNVIPET
0 1 R365 ILTKYSARDLQNLMS
0 2 Y387-p VSSLSRTyKESRNAF
0 1 Y482-p AIKERIGyPDDIVSN
0 1 Y497-p DNKLNNEyLELNyKE
0 1 Y502-p NEyLELNyKEDEYFE
  mouse

 
S4-p ____MGRsEsQMDIt
S6-p __MGRsEsQMDItDI
T11-p sEsQMDItDINAPKP
A15 MDItDINAPKPKKKQ
K85 EPCTDFFKYACGGWL
K93 YACGGWLKRNVIPET
R365-m1 ILTKYSPrDLQNLMS
Y387 VSSLSRNYKESRNAF
Y482 AIKERIGYPDDIISN
Y497 ENKLNNEYLELNYRE
Y502 NEYLELNYREDEYFE
  rat

 
S4-p ____MGRsEsQMDIT
S6-p __MGRsEsQMDITDI
T11 sEsQMDITDINAPKP
A15 MDITDINAPKPKKKQ
K85 EPCTDFFKYACGGWL
K93 YACGGWLKRNVIPET
R365 ILTKYSPRDLQNLMS
Y387 VSSLSRNYKESRNAF
Y482 AIKERIGYPDDIISN
Y497 ENKLNNEYLELNYKE
Y502 NEYLELNYKEEEYFE
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