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CD10 (human)

Overview CD10 Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Note: This description may include information from UniProtKB. Protein type: Protease; EC 3.4.24.11; Membrane protein, integral Cellular Component: synaptic vesicle; axon; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; integral to membrane; synapse; brush border Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity; peptide binding Biological Process: peptide metabolic process; beta-amyloid metabolic process; creatinine metabolic process; kidney development; sensory perception of pain; proteolysis Reference #:  P08473 (UniProtKB) Alt. Names/Synonyms: Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; Enkephalinase; EPN; membrane metallo-endopeptidase; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11 Gene Symbols: MME Molecular weight: 85,514 Da Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CD10 1DL9 - A=508-750 (human) 1DMT - A=55-750 (human) 1QVD - A=55-750 (human) 1R1H - A=55-750 (human) 1R1I - A=55-750 (human) 1R1J - A=55-750 (human) 1Y8J - A=55-750 (human) 2QPJ - A=55-750 (human) 2YB9 - A=55-750 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S6‑p phosphorylation: S6‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	3		S4-p	____MGKsEsQMDIt
2	16		S6-p	__MGKsEsQMDItDI
1	0		T11-p	sEsQMDItDINtPKP
0	1		T15-p	MDItDINtPKPKKKQ
0	1		K85-a	EPCTDFFkYACGGWL
0	1		K93-a	YACGGWLkRNVIPET
0	1		R365	ILTKYSARDLQNLMS
0	2		Y387-p	VSSLSRTyKESRNAF
0	1		Y482-p	AIKERIGyPDDIVSN
0	1		Y497-p	DNKLNNEyLELNyKE
0	1		Y502-p	NEyLELNyKEDEYFE

	mouse
S4-p	____MGRsEsQMDIt
S6-p	__MGRsEsQMDItDI
T11-p	sEsQMDItDINAPKP
A15	MDItDINAPKPKKKQ
K85	EPCTDFFKYACGGWL
K93	YACGGWLKRNVIPET
R365-m1	ILTKYSPrDLQNLMS
Y387	VSSLSRNYKESRNAF
Y482	AIKERIGYPDDIISN
Y497	ENKLNNEYLELNYRE
Y502	NEYLELNYREDEYFE

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