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NMDAR2B (human)

Overview NMDAR2B a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB. Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral Cellular Component: neuron projection; cell surface; integral to plasma membrane; postsynaptic density; terminal button; Z disc; N-methyl-D-aspartate selective glutamate receptor complex; presynaptic membrane; postsynaptic membrane; synaptic vesicle; plasma membrane; cell junction; outer membrane-bounded periplasmic space Molecular Function: neurotransmitter binding; zinc ion binding; calcium channel activity; beta-catenin binding; drug binding; ionotropic glutamate receptor binding; protein binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; cell adhesion molecule binding; D2 dopamine receptor binding Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; behavioral fear response; rhythmic process; positive regulation of glutamate secretion; response to other organism; receptor clustering; positive regulation of synaptic transmission; response to carbohydrate stimulus; synaptic transmission; response to magnesium ion; behavioral response to pain; learning and/or memory; transport; response to methylmercury; response to electrical stimulus; associative learning; cellular response to magnesium starvation; regulation of action potential; in utero embryonic development; glutamate signaling pathway; hippocampus development; response to amphetamine; response to cocaine; detection of mechanical stimulus involved in sensory perception of pain; sensory organ development; response to ethanol; suckling behavior; long-term memory; response to cytokine stimulus; regulation of MAPKKK cascade; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential Reference #:  Q13224 (UniProtKB) Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN2B; hNR3; MGC142178; MGC142180; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NR2B; NR3 Gene Symbols: GRIN2B Molecular weight: 166,367 Da Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NMDAR2B 1S11 - A=403-543, B=660-801 (human) 1S2S - A=405-543, B=660-801 (human) 2IPV - X=404-768 (human) 3JPW - A=32-394 (rat) 3JPY - A=32-394 (rat) 3QEL - D/B=31-394 (rat) 3QEM - D/B=31-394 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1S11 1S2S 2IPV  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S1303‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y239-p	CTKEEATyIFEVANS
0	1		Y338	QSNMLNRYLINVTFE
0	1		T475-p	ISKSVKFtYDLYLVT
0	2		T493-p	HGKKINGtWNGMIGE
0	1		T514-p	YMAVGSLtINEERSE
0	1		Y705-p	NYAEMHAyMGKFNQR
0	1		S720-p	GVDDALLsLKTGKLD
0	1		S759-p	GSGKVFAstGyGIAI
0	1		T760-p	SGKVFAstGyGIAIQ
0	1		Y762-p	KVFAstGyGIAIQKD
0	1		S770-p	GIAIQKDsGWKRQVD
0	1		S855	HCFMGVCSGKPGMVF
0	1		S865-p	PGMVFSIsRGIYSCI
0	4		S882	VAIEERQSVMNSPTA
1	3		S886	ERQSVMNSPTATMNN
0	1		K906	LRLLRTAKNMANLSG
1	6		S917	NLSGVNGSPQSALDF
0	4		S920	GVNGSPQSALDFIRR
0	5		S929	LDFIRRESSVYDISE
0	6		S930	DFIRRESSVYDISEH
0	56		Y932	IRRESSVYDISEHRR
0	1		S935	ESSVYDISEHRRSFT
0	1		S940	DISEHRRSFTHSDCK
0	12		Y949-p	THSDCKSyNNPPCEE
0	53		Y962-p	EENLFSDyISEVERT
0	3		S964	NLFSDyISEVERTFG
0	1		S978	GNLQLKDSNVYQDHY
0	1		K1021	QSRSISKKPLDIGLP
0	1		K1031	DIGLPSSKHSQLSDL
0	178		Y1039-p	HSQLSDLyGKFsFKS
0	1		K1041	QLSDLyGKFsFKSDR
0	4		S1043-p	SDLyGKFsFKSDRyS
0	21		Y1049-p	FsFKSDRySGHDDLI
0	1		S1050	sFKSDRySGHDDLIR
0	2		S1058	GHDDLIRSDVSDIST
0	2		S1061	DLIRSDVSDISTHTV
0	1		S1064	RSDVSDISTHTVTyG
0	1		T1065	SDVSDISTHTVTyGN
0	3		T1067	VSDISTHTVTyGNIE
0	136		Y1070-p	ISTHTVTyGNIEGNA
0	1		S1088-p	RKQQYKDsLKKRPAS
0	52		Y1109-p	FDEIELAyRRRPPRs
0	2		S1116-p	yRRRPPRsPDHKRYF
0	1		K1126	HKRYFRDKEGLRDFY
0	28		Y1133	KEGLRDFYLDQFRTK
0	1		T1139	FYLDQFRTKENSPHW
0	2		S1143	QFRTKENSPHWEHVD
0	54		Y1155-p	HVDLTDIyKERSDDF
0	3		S1166-p	SDDFKRDsVsGGGPC
0	1		S1168-p	DFKRDsVsGGGPCTN
0	1		S1191-p	GDKHGVVsGVPAPWE
0	2		K1221	FCRSCPSKLHNYSTT
0	78		Y1225	CPSKLHNYSTTVTGQ
0	1		S1234	TTVTGQNSGRQACIR
2	27		Y1252	CKKAGNLYDISEDNS
0	3		S1255	AGNLYDISEDNSLQE
0	5		S1259	YDISEDNSLQELDQP
0	1		K1280-a	TSNASTTkYPQsPTN
0	2		S1284-p	STTkYPQsPTNSkAQ
0	2		T1286	TkYPQsPTNSkAQKK
0	1		K1289-a	PQsPTNSkAQKKNRN
18	20		S1303-p	NKLRRQHsyDtFVDL
0	34		Y1304-p	KLRRQHsyDtFVDLQ
0	5		T1306-p	RRQHsyDtFVDLQKE
3	1		S1323-p	ALAPRSVsLKDKGRF
0	1		S1334-p	KGRFMDGsPYAHMFE
4	7		Y1336	RFMDGsPYAHMFEMS
0	21		Y1371	HNNPGGGYMLSKSLY
0	1		K1402	QCLLHGSKSYFFRQP
0	1		Y1404	LLHGSKSYFFRQPTV
0	1		K1428	FRALVTNKPVVSALH
0	1		K1428	FRALVTNKPVVSALH
0	2		K1460	NPCVPNNKNPRAFNG
0	1		S1469-p	PRAFNGSsNGHVyEK
19	102		Y1474-p	GSsNGHVyEKLSSIE
1	0		S1482	EKLSSIESDV_____

	mouse
Y239	CTKEEATYIFEVANS
Y338	QSNMLNRYLINVTFE
T475	ISKSVKFTYDLYLVT
T493	HGKKINGTWNGMIGE
T514	YMAVGSLTINEERSE
Y705	NYAEMHAYMGKFNQR
S720	GVDDALLSLKTGKLD
S759	GSGKVFASTGYGIAI
T760	SGKVFASTGYGIAIQ
Y762	KVFASTGYGIAIQKD
S770	GIAIQKDSGWKRQVD
S855-p	HCFMGVCsGKPGMVF
S865	PGMVFSISRGIYSCI
S882-p	VAIEERQsVMNsPTA
S886-p	ERQsVMNsPTATMNN
K906-u	LRLLRTAkNMANLSG
S917-p	NLSGVNGsPQsALDF
S920-p	GVNGsPQsALDFIRR
S929-p	LDFIRREssVyDIsE
S930-p	DFIRREssVyDIsEH
Y932-p	IRREssVyDIsEHRR
S935-p	EssVyDIsEHRRsFT
S940-p	DIsEHRRsFTHSDCK
Y949-p	THSDCKSyNNPPCEE
Y962-p	EENLFSDyIsEVERT
S964-p	NLFSDyIsEVERTFG
S978-p	GNLQLKDsNVYQDHY
K1021-u	QPRSISKkPLDIGLP
K1031-u	DIGLPSSkHSQLSDL
Y1039-p	HSQLSDLyGkFsFKS
K1041-u	QLSDLyGkFsFKSDR
S1043-p	SDLyGkFsFKSDRys
Y1049-p	FsFKSDRysGHDDLI
S1050-p	sFKSDRysGHDDLIR
S1058-p	GHDDLIRsDVsDIst
S1061-p	DLIRsDVsDIstHtV
S1064-p	RsDVsDIstHtVTyG
T1065-p	sDVsDIstHtVTyGN
T1067-p	VsDIstHtVTyGNIE
Y1070-p	IstHtVTyGNIEGNA
S1088-p	RKQQYKDsLKKRPAS
Y1109-p	FDEIELAyRRRPPRs
S1116-p	yRRRPPRsPDHKRYF
K1126-u	HKRYFRDkEGLRDFY
Y1133	kEGLRDFYLDQFRtK
T1139-p	FYLDQFRtKENsPHW
S1143-p	QFRtKENsPHWEHVD
Y1155-p	HVDLTDIyKERSDDF
S1166-p	SDDFKRDsVSGGGPC
S1168	DFKRDsVSGGGPCTN
G1191	GDKHGVVGGVPAPWE
K1221	FCRSCPSKLHNySST
Y1225-p	CPSKLHNySSTVAGQ
S1234-p	STVAGQNsGRQACIR
Y1252-p	CKKAGNLyDIsEDNs
S1255-p	AGNLyDIsEDNsLQE
S1259-p	yDIsEDNsLQELDQP
K1280	SSNASTTKYPQsPtN
S1284-p	STTKYPQsPtNSKAQ
T1286-p	TKYPQsPtNSKAQKK
K1289	PQsPtNSKAQKKNRN
S1303-p	NKLRRQHsyDtFVDL
Y1304-p	KLRRQHsyDtFVDLQ
T1306-p	RRQHsyDtFVDLQKE
S1323-p	ALAPRSVsLKDKGRF
S1334-p	KGRFMDGsPyAHMFE
Y1336-p	RFMDGsPyAHMFEMP
Y1369-p	HNNPGSGyMLSKSLY
K1400	QCLLHGSKSYFFRQP
Y1402	LLHGSKSYFFRQPTV
K1426-a	FRALVTNkPVVSALH
K1426-u	FRALVTNkPVVSALH
K1458-u	NPCVPNNkNPRAFNG
S1467	PRAFNGSSNGHVyEK
Y1472-p	GSSNGHVyEKLSSIE
S1480	EKLSSIESDV_____

	rat
Y239	CTKEEATYIFEVANS
Y338-p	QSNMLNRyLINVTFE
T475	ISKSVKFTYDLYLVT
T493	HGKKINGTWNGMIGE
T514	YMAVGSLTINEERSE
Y705	NYAEMHAYMGKFNQR
S720	GVDDALLSLKTGKLD
S759	GSGKVFASTGYGIAI
T760	SGKVFASTGYGIAIQ
Y762	KVFASTGYGIAIQKD
S770	GIAIQKDSGWKRQVD
S855	HCFMGVCSGKPGMVF
S865	PGMVFSISRGIYSCI
S882	VAIEERQSVMNsPTA
S886-p	ERQSVMNsPTATMNN
K906	LRLLRTAKNMANLSG
S917-p	NLSGVNGsPQSALDF
S920	GVNGsPQSALDFIRR
S929	LDFIRRESsVyDISE
S930-p	DFIRRESsVyDISEH
Y932-p	IRRESsVyDISEHRR
S935	ESsVyDISEHRRSFT
S940	DISEHRRSFTHSDCK
Y949-p	THSDCKSyNNPPCEE
Y962-p	EENLFSDyISEVERT
S964	NLFSDyISEVERTFG
S978	GNLQLKDSNVYQDHY
K1021	QPRSISKKPLDIGLP
K1031	DIGLPSSKHSQLSDL
Y1039-p	HSQLSDLyGKFSFKS
K1041	QLSDLyGKFSFKSDR
S1043	SDLyGKFSFKSDRyS
Y1049-p	FSFKSDRySGHDDLI
S1050	SFKSDRySGHDDLIR
S1058	GHDDLIRSDVSDIST
S1061	DLIRSDVSDISTHTV
S1064	RSDVSDISTHTVTyG
T1065	SDVSDISTHTVTyGN
T1067	VSDISTHTVTyGNIE
Y1070-p	ISTHTVTyGNIEGNA
S1088	RKQQYKDSLKKRPAS
Y1109-p	FDEIELAyRRRPPRS
S1116	yRRRPPRSPDHKRYF
K1126	HKRYFRDKEGLRDFy
Y1133-p	KEGLRDFyLDQFRTK
T1139	FyLDQFRTKENSPHW
S1143	QFRTKENSPHWEHVD
Y1155-p	HVDLTDIyKERSDDF
S1166	SDDFKRDSVSGGGPC
S1168	DFKRDSVSGGGPCTN
G1191	GEKHGVVGGVPAPWE
K1221-u	FCRSCPSkLHNySST
Y1225-p	CPSkLHNySSTVAGQ
S1234	STVAGQNSGRQACIR
Y1252-p	CKKAGNLyDISEDNS
S1255	AGNLyDISEDNSLQE
S1259	yDISEDNSLQELDQP
K1280	TSNASSTKYPQSPTN
S1284	SSTKYPQSPTNSKAQ
T1286	TKYPQSPTNSKAQKK
K1289	PQSPTNSKAQKKNRN
S1303-p	NKLRRQHsyDtFVDL
Y1304-p	KLRRQHsyDtFVDLQ
T1306-p	RRQHsyDtFVDLQKE
S1323-p	ALAPRSVsLKDKGRF
S1334	KGRFMDGSPyAHMFE
Y1336-p	RFMDGSPyAHMFEMP
Y1369-p	HNNPGSGyMLSKSLY
K1400-u	QCLLHGSkSyFFRQP
Y1402-p	LLHGSkSyFFRQPTV
K1426	FRALVTNKPVVVTLH
K1426	FRALVTNKPVVVTLH
K1458	NPCVPNNKNPRAFNG
S1467	PRAFNGSSNGHVyEK
Y1472-p	GSSNGHVyEKLSSIE
S1480-p	EKLSSIEsDV_____

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