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Protein Page:
NMDAR2B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NMDAR2B a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, ligand-gated; Channel, calcium; Membrane protein, multi-pass
Cellular Component: postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; integral to plasma membrane; dendrite; postsynaptic density; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity; glycine binding
Biological Process: synaptic transmission, glutamatergic; behavioral fear response; startle response; glutamate signaling pathway; in utero embryonic development; regulation of synaptic plasticity; learning; memory; synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; behavioral response to pain; learning and/or memory; sensory organ development; response to ethanol; suckling behavior; ionotropic glutamate receptor signaling pathway; transport; regulation of excitatory postsynaptic membrane potential
Reference #:  Q13224 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN2B; hNR3; MGC142178; MGC142180; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NR2B; NR3
Gene Symbols: GRIN2B
Molecular weight: 166,367 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NMDAR2B

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S1303‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T493-p HGKKINGtWNGMIGE
0 1 Y705-p NYAEMHAyMGKFNQR
0 4 S882 VAIEERQSVMNSPTA
1 3 S886 ERQSVMNSPTATMNN
0 1 K906 LRLLRTAKNMANLSG
1 6 S917 NLSGVNGSPQSALDF
0 4 S920 GVNGSPQSALDFIRR
0 5 S929 LDFIRRESSVYDISE
0 6 S930 DFIRRESSVYDISEH
0 56 Y932 IRRESSVYDISEHRR
0 1 S940 DISEHRRSFTHSDCK
0 12 Y949 THSDCKSYNNPPCEE
0 53 Y962 EENLFSDYISEVERT
0 3 S964 NLFSDYISEVERTFG
0 1 K1021 QSRSISKKPLDIGLP
0 1 K1031 DIGLPSSKHSQLSDL
0 178 Y1039-p HSQLSDLyGKFSFKS
0 1 K1041 QLSDLyGKFSFKSDR
0 4 S1043 SDLyGKFSFKSDRYS
0 21 Y1049 FSFKSDRYSGHDDLI
0 1 S1050 SFKSDRYSGHDDLIR
0 2 S1058 GHDDLIRSDVSDIST
0 2 S1061 DLIRSDVSDISTHTV
0 1 S1064 RSDVSDISTHTVTYG
0 1 T1065 SDVSDISTHTVTYGN
0 3 T1067 VSDISTHTVTYGNIE
0 136 Y1070 ISTHTVTYGNIEGNA
0 52 Y1109 FDEIELAYRRRPPRS
0 2 S1116 YRRRPPRSPDHKRYF
0 1 K1126 HKRYFRDKEGLRDFY
0 28 Y1133 KEGLRDFYLDQFRTK
0 1 T1139 FYLDQFRTKENSPHW
0 2 S1143 QFRTKENSPHWEHVD
0 54 Y1155 HVDLTDIYKERSDDF
1 3 S1166-p SDDFKRDsVSGGGPC
0 2 K1221 FCRSCPSKLHNYSTT
0 78 Y1225 CPSKLHNYSTTVTGQ
0 1 S1234 TTVTGQNSGRQACIR
2 27 Y1252 CKKAGNLYDISEDNS
0 3 S1255 AGNLYDISEDNSLQE
0 5 S1259 YDISEDNSLQELDQP
0 1 K1280-a TSNASTTkYPQSPTN
0 2 S1284 STTkYPQSPTNSkAQ
0 2 T1286 TkYPQSPTNSkAQKK
0 1 K1289-a PQSPTNSkAQKKNRN
21 20 S1303-p NKLRRQHsyDtFVDL
0 34 Y1304-p KLRRQHsyDtFVDLQ
0 5 T1306-p RRQHsyDtFVDLQKE
3 1 S1323-p ALAPRSVsLKDKGRF
0 1 S1334 KGRFMDGSPYAHMFE
5 7 Y1336 RFMDGSPYAHMFEMS
0 21 Y1371 HNNPGGGYMLSKSLY
0 1 K1428 FRALVTNKPVVSALH
0 2 K1460 NPCVPNNKNPRAFNG
20 102 Y1474-p GSSNGHVyEKLSSIE
1 0 S1482 EKLSSIESDV_____
4209 : Phospho-NMDAR2B (Tyr1070) Antibody
5355 : Phospho-NMDAR2B (Ser1284) Antibody
4208 : Phospho-NMDAR2B (Tyr1472) Antibody
  mouse

 
T493 HGKKINGTWNGMIGE
Y705 NYAEMHAYMGKFNQR
S882-p VAIEERQsVMNsPTA
S886-p ERQsVMNsPTATMNN
K906-u LRLLRTAkNMANLSG
S917-p NLSGVNGsPQsALDF
S920-p GVNGsPQsALDFIRR
S929-p LDFIRREssVyDISE
S930-p DFIRREssVyDISEH
Y932-p IRREssVyDISEHRR
S940-p DISEHRRsFTHSDCK
Y949-p THSDCKSyNNPPCEE
Y962-p EENLFSDyIsEVERT
S964-p NLFSDyIsEVERTFG
K1021-u QPRSISKkPLDIGLP
K1031-u DIGLPSSkHSQLSDL
Y1039-p HSQLSDLyGkFsFKS
K1041-u QLSDLyGkFsFKSDR
S1043-p SDLyGkFsFKSDRys
Y1049-p FsFKSDRysGHDDLI
S1050-p sFKSDRysGHDDLIR
S1058-p GHDDLIRsDVsDIst
S1061-p DLIRsDVsDIstHtV
S1064-p RsDVsDIstHtVTyG
T1065-p sDVsDIstHtVTyGN
T1067-p VsDIstHtVTyGNIE
Y1070-p IstHtVTyGNIEGNA
Y1109-p FDEIELAyRRRPPRs
S1116-p yRRRPPRsPDHKRYF
K1126-u HKRYFRDkEGLRDFY
Y1133 kEGLRDFYLDQFRtK
T1139-p FYLDQFRtKENsPHW
S1143-p QFRtKENsPHWEHVD
Y1155-p HVDLTDIyKERSDDF
S1166-p SDDFKRDsVSGGGPC
K1221 FCRSCPSKLHNySST
Y1225-p CPSKLHNySSTVAGQ
S1234-p STVAGQNsGRQACIR
Y1252-p CKKAGNLyDIsEDNs
S1255-p AGNLyDIsEDNsLQE
S1259-p yDIsEDNsLQELDQP
K1280 SSNASTTKYPQsPtN
S1284-p STTKYPQsPtNSKAQ
T1286-p TKYPQsPtNSKAQKK
K1289 PQsPtNSKAQKKNRN
S1303-p NKLRRQHsyDtFVDL
Y1304-p KLRRQHsyDtFVDLQ
T1306-p RRQHsyDtFVDLQKE
S1323-p ALAPRSVsLKDKGRF
S1334-p KGRFMDGsPyAHMFE
Y1336-p RFMDGsPyAHMFEMP
Y1369-p HNNPGSGyMLSKSLY
K1426-u FRALVTNkPVVSALH
K1458-u NPCVPNNkNPRAFNG
Y1472-p GSSNGHVyEKLSSIE
S1480 EKLSSIESDV_____
4209 : Phospho-NMDAR2B (Tyr1070) Antibody
5355 : Phospho-NMDAR2B (Ser1284) Antibody
4208 : Phospho-NMDAR2B (Tyr1472) Antibody
  rat

 
T493 HGKKINGTWNGMIGE
Y705 NYAEMHAYMGKFNQR
S882 VAIEERQSVMNsPTA
S886-p ERQSVMNsPTATMNN
K906 LRLLRTAKNMANLSG
S917-p NLSGVNGsPQSALDF
S920 GVNGsPQSALDFIRR
S929 LDFIRRESsVyDISE
S930-p DFIRRESsVyDISEH
Y932-p IRRESsVyDISEHRR
S940 DISEHRRSFTHSDCK
Y949-p THSDCKSyNNPPCEE
Y962-p EENLFSDyISEVERT
S964 NLFSDyISEVERTFG
K1021 QPRSISKKPLDIGLP
K1031 DIGLPSSKHSQLSDL
Y1039-p HSQLSDLyGKFSFKS
K1041 QLSDLyGKFSFKSDR
S1043 SDLyGKFSFKSDRyS
Y1049-p FSFKSDRySGHDDLI
S1050 SFKSDRySGHDDLIR
S1058 GHDDLIRSDVSDIST
S1061 DLIRSDVSDISTHTV
S1064 RSDVSDISTHTVTyG
T1065 SDVSDISTHTVTyGN
T1067 VSDISTHTVTyGNIE
Y1070-p ISTHTVTyGNIEGNA
Y1109-p FDEIELAyRRRPPRS
S1116 yRRRPPRSPDHKRYF
K1126 HKRYFRDKEGLRDFy
Y1133-p KEGLRDFyLDQFRTK
T1139 FyLDQFRTKENSPHW
S1143 QFRTKENSPHWEHVD
Y1155-p HVDLTDIyKERSDDF
S1166-p SDDFKRDsVSGGGPC
K1221-u FCRSCPSkLHNySST
Y1225-p CPSkLHNySSTVAGQ
S1234 STVAGQNSGRQACIR
Y1252-p CKKAGNLyDISEDNS
S1255 AGNLyDISEDNSLQE
S1259 yDISEDNSLQELDQP
K1280 TSNASSTKYPQSPTN
S1284 SSTKYPQSPTNSKAQ
T1286 TKYPQSPTNSKAQKK
K1289 PQSPTNSKAQKKNRN
S1303-p NKLRRQHsyDtFVDL
Y1304-p KLRRQHsyDtFVDLQ
T1306-p RRQHsyDtFVDLQKE
S1323-p ALAPRSVsLKDKGRF
S1334 KGRFMDGSPyAHMFE
Y1336-p RFMDGSPyAHMFEMP
Y1369-p HNNPGSGyMLSKSLY
K1426 FRALVTNKPVVVTLH
K1458 NPCVPNNKNPRAFNG
Y1472-p GSSNGHVyEKLSSIE
S1480-p EKLSSIEsDV_____
4209 : Phospho-NMDAR2B (Tyr1070) Antibody
5355 : Phospho-NMDAR2B (Ser1284) Antibody
4208 : Phospho-NMDAR2B (Tyr1472) Antibody
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