a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral
Cellular Component: neuron projection; cell surface; integral to plasma membrane; postsynaptic density; terminal button; Z disc; N-methyl-D-aspartate selective glutamate receptor complex; presynaptic membrane; postsynaptic membrane; synaptic vesicle; plasma membrane; cell junction; outer membrane-bounded periplasmic space
Molecular Function: neurotransmitter binding; zinc ion binding; calcium channel activity; beta-catenin binding; drug binding; ionotropic glutamate receptor binding; protein binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; cell adhesion molecule binding; D2 dopamine receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; behavioral fear response; rhythmic process; positive regulation of glutamate secretion; response to other organism; receptor clustering; positive regulation of synaptic transmission; response to carbohydrate stimulus; synaptic transmission; response to magnesium ion; behavioral response to pain; learning and/or memory; transport; response to methylmercury; response to electrical stimulus; associative learning; cellular response to magnesium starvation; regulation of action potential; in utero embryonic development; glutamate signaling pathway; hippocampus development; response to amphetamine; response to cocaine; detection of mechanical stimulus involved in sensory perception of pain; sensory organ development; response to ethanol; suckling behavior; long-term memory; response to cytokine stimulus; regulation of MAPKKK cascade; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.