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PTPN23 (human)

Overview PTPN23 May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasm; nucleus; endosome; basal body; cilium Molecular Function: protein binding; protein tyrosine phosphatase activity Reference #:  Q9H3S7 (UniProtKB) Alt. Names/Synonyms: DKFZp564F0923; HD-PTP; HDPTP; His domain-containing protein tyrosine phosphatase; His-domain protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase TD14; protein tyrosine phosphatase, non-receptor type 23; PTN23; PTP-TD14; PTPN23; Tyrosine-protein phosphatase non-receptor type 23 Gene Symbols: PTPN23 Molecular weight: 178,974 Da Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states

Select Structure to View Below PTPN23 3RAU - A/B=2-361 (human) 2W10 - D/C=719-730 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K32-u	AVKKFVLkNYGENPE
0	1		K46-u	EAYNEELkKLELLRQ
0	3		Y213-p	ISAQVVDyYKEACRA
0	8		K279-u	YFQSALDkLNEAIkL
0	3		K285-u	DkLNEAIkLAkGQPD
0	2		K288-u	NEAIkLAkGQPDTVQ
0	2		K340-u	VKGAPLVkPLPVNPT
0	7		K472-u	EDELLEQkFQEAVGQ
0	1		K500	EVRREWAKYMEVHEK
0	1		S509-p	MEVHEKAsFtNsELH
0	1		T511-p	VHEKAsFtNsELHRA
0	1		S513-p	EKAsFtNsELHRAMN
0	1		K600	TDHSEMKKLFEEQLK
0	1		K600	TDHSEMKKLFEEQLK
0	1		K607	KLFEEQLKKYDQLKV
0	1		Y679-p	SQEGRDFyADLESKV
0	1		T693-p	VAALLERtQStCQAR
0	1		T696-p	LLERtQStCQAREAA
0	2		P741	EAVEAGDPPEELRSL
0	2		S1122-p	AAADLLSssPEsQHG
0	6		S1123-p	AADLLSssPEsQHGG
0	2		S1126-p	LLSssPEsQHGGTQs
0	1		T1131	PEsQHGGTQsPGGGQ
0	4		S1133-p	sQHGGTQsPGGGQPL
0	64		Y1165-p	RLIERDPyEHPERLR
0	56		Y1229-p	RHQDVMPyDSNRVVL
0	1		T1269	TQAPLPGTAADFWLM
0	1		S1290-p	SVIVMLVsEAEMEKQ
0	1		S1475-p	PLASASIsQKNHLPQ
0	1		S1589-p	SLTPEAFsLDSSLRG
0	1		S1601-p	LRGKQRMsKHNFLQA
0	1		S1625-p	RPSDDPLsLLDPLWt
0	1		T1632-p	sLLDPLWtLNkT___
0	5		K1635-u	DPLWtLNkT______

	mouse
K32-u	AVKKFVLkNYGENPE
K46	EAYNEELKKLELLRQ
Y213	ISAQVVDYYKEACRA
K279-u	YFQSALDkLNEAIkL
K285-u	DkLNEAIkLAkGQPD
K288-u	NEAIkLAkGQPDTVQ
K340-u	VKGAPLVkPLPVNPT
K472	EDELQEQKLQETLGQ
K502-u	EVRREWAkYMEVHEK
S511	MEVHEKASFTNSELH
T513	VHEKASFTNSELHRA
S515	EKASFTNSELHRAMN
K602-a	TDHSEMKkLFEEQLk
K602-u	TDHSEMKkLFEEQLk
K609-a	kLFEEQLkKYDQLKV
Y681	SQEGKDFYADLESKV
A695	VATLLERAQSICRAQ
I698	LLERAQSICRAQEAA
T744-p	EAVEAGDtPEELRSL
S1178-p	AAADLLSssPESQHG
S1179-p	AADLLSssPESQHGG
S1182	LLSssPESQHGGtQP
T1187-p	PESQHGGtQPPGGGQ
P1189	SQHGGtQPPGGGQPL
Y1221	RLIEQDPYEHPERLQ
Y1285	RHQDVMPYDSNRVVL
T1325-p	TQAPLPGtAADFWLM
S1346	SVIVMLVSEAEMEKQ
S1531	PVASVNISQKNHLPQ
S1645	SLTPEAFSLDSSLRG
S1657	LRGKQRMSKQNFLQA
S1681	QPTDDPLSLLDPLWT
T1688	SLLDPLWTLNkT___
K1691-u	DPLWTLNkT______

	rat
-	gap
-	gap
Y38	ISAQVVDYYKEACRA
K104	YFQSALDKLNEAIKL
K110	DKLNEAIKLAKGQPD
K113	NEAIKLAKGQPDTVQ
K165	VKGAPLVKPLPVNPT
K297	EDELQEQKLQETLGQ
K327	EVRREWAKYTEVHEK
S336	TEVHEKASFTNSELH
T338	VHEKASFTNSELHRA
S340	EKASFTNSELHRAMN
K427	TDHSEMKKLFEEQLK
K427	TDHSEMKKLFEEQLK
K434	KLFEEQLKKYDQLKV
Y506	SQEGKDFYADLESKV
A520	VAALLERAQSLCRAQ
L523	LLERAQSLCRAQEAA
Q569	EAAEAGDQPEELRSL
S985	AAADLLSSsPESQHG
S986-p	AADLLSSsPESQHGG
S989	LLSSsPESQHGGTQP
T994	PESQHGGTQPPGGGQ
P996	SQHGGTQPPGGGQPL
Y1028	RLIEQDPYEHPERLQ
Y1092	RHQDVMPYDSNRVVL
T1132	TQRPLPGTAADFWLM
S1153	SVIVMLVSEAEMEKQ
S1338	PVASMSVSQKSHLPQ
S1452	SLTPEAFSLDSSLRG
S1464	LRGKQRMSKQNFLQA
S1488	QPTDDPLSLLDPLWT
T1495	SLLDPLWTLNKT___
K1498	DPLWTLNKT______

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