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Protein Page:
PTPN23 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTPN23 May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Cellular Component: early endosome; cytoplasmic membrane-bound vesicle; cytoplasm; nucleolus; nucleus; endosome
Molecular Function: protein binding; protein tyrosine phosphatase activity
Biological Process: protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; regulation of cell migration
Reference #:  Q9H3S7 (UniProtKB)
Alt. Names/Synonyms: DKFZp564F0923; HD-PTP; HDPTP; His domain-containing protein tyrosine phosphatase; His-domain protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase TD14; protein tyrosine phosphatase, non-receptor type 23; PTN23; PTP-TD14; PTPN23; Tyrosine-protein phosphatase non-receptor type 23
Gene Symbols: PTPN23
Molecular weight: 178,974 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Select Structure to View Below

PTPN23

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K32-ub AVKKFVLkNYGENPE
0 1 K46-ub EAYNEELkKLELLRQ
0 3 Y213-p ISAQVVDyYKEACRA
0 8 K279-ub YFQSALDkLNEAIkL
0 3 K285-ub DkLNEAIkLAkGQPD
0 2 K288-ub NEAIkLAkGQPDtVQ
0 1 T293-p LAkGQPDtVQDALRF
0 2 K340-ub VKGAPLVkPLPVNPT
0 7 K472-ub EDELLEQkFQEAVGQ
0 1 S484-p VGQAGAIsITSKAEL
0 1 K500 EVRREWAKYMEVHEK
0 1 S509-p MEVHEKAsFtNsELH
0 1 T511-p VHEKAsFtNsELHRA
0 1 S513-p EKAsFtNsELHRAMN
0 1 K600 TDHSEMKKLFEEQLK
0 1 K600 TDHSEMKKLFEEQLK
0 1 K607 KLFEEQLKkYDQLkV
0 1 K608-m2 LFEEQLKkYDQLkVY
0 1 K613-m2 LKkYDQLkVYLEQNL
0 1 Y679-p SQEGRDFyADLESKV
0 1 T693-p VAALLERtQStCQAR
0 1 T696-p LLERtQStCQAREAA
0 1 S733-p LLPRREEsEAVEAGD
0 2 P741 EAVEAGDPPEELRsL
0 1 S747-p DPPEELRsLPPDMVA
0 1 R950-m1 PAGFPAPrIGPQPQP
0 2 S1121-p AAAADLLsssPEsQH
0 6 S1122-p AAADLLsssPEsQHG
0 9 S1123-p AADLLsssPEsQHGG
0 5 S1126-p LLsssPEsQHGGtQs
0 4 T1131-p PEsQHGGtQsPGGGQ
0 6 S1133-p sQHGGtQsPGGGQPL
0 67 Y1165-p RLIERDPyEHPERLR
0 51 Y1229-p RHQDVMPyDSNRVVL
0 1 T1269 TQAPLPGTAADFWLM
0 1 S1290-p SVIVMLVsEAEMEKQ
0 1 S1475-p PLASASIsQKNHLPQ
0 1 S1484-p KNHLPQDsQDLVLGG
0 1 S1542-p PESTPIPsSSPPPLs
0 1 S1549-p sSSPPPLsSPLPEAP
0 1 S1589-p SLTPEAFsLDSsLrG
0 1 S1593-p EAFsLDSsLrGKQRM
0 1 R1595-m1 FsLDSsLrGKQRMsK
0 1 S1601-p LrGKQRMsKHNFLQA
0 1 R1615-m1 AHNGQGLrATrPSDD
0 1 R1618-m1 GQGLrATrPSDDPLs
0 1 S1625-p rPSDDPLsLLDPLWt
0 1 T1632-p sLLDPLWtLNkt___
0 5 K1635-ub DPLWtLNkt______
0 1 T1636-p PLWtLNkt_______
  mouse

 
K32-ub AVKKFVLkNYGENPE
K46 EAYNEELKKLELLRQ
Y213 ISAQVVDYYKEACRA
K279-ub YFQSALDkLNEAIkL
K285-ub DkLNEAIkLAkGQPD
K288-ub NEAIkLAkGQPDTVQ
T293 LAkGQPDTVQDALRF
K340-ub VKGAPLVkPLPVNPT
K472 EDELQEQKLQETLGQ
P484 LGQAGAGPGPSVAKA
K502-ub EVRREWAkYMEVHEK
S511 MEVHEKASFTNSELH
T513 VHEKASFTNSELHRA
S515 EKASFTNSELHRAMN
K602-ac TDHSEMKkLFEEQLk
K602-ub TDHSEMKkLFEEQLk
K609-ac kLFEEQLkKYDQLKV
K610 LFEEQLkKYDQLKVY
K615 LkKYDQLKVYLEQNL
Y681 SQEGKDFYADLESKV
A695 VATLLERAQSICRAQ
I698 LLERAQSICRAQEAA
G736 LLSRREEGEAVEAGD
T744-p EAVEAGDtPEELRSL
S750 DtPEELRSLPPDMMV
R974 PTGFPVPRTGPQAQA
S1177-p AAAADLLsssPEsQH
S1178-p AAADLLsssPEsQHG
S1179-p AADLLsssPEsQHGG
S1182-p LLsssPEsQHGGtQP
T1187-p PEsQHGGtQPPGGGQ
P1189 sQHGGtQPPGGGQPL
Y1221 RLIEQDPYEHPERLQ
Y1285 RHQDVMPYDSNRVVL
T1325-p TQAPLPGtAADFWLM
S1346 SVIVMLVSEAEMEKQ
S1531 PVASVNISQKNHLPQ
S1540 KNHLPQDSQDLVLGG
S1598 PESTPVPSSSPPPLS
S1605 SSSPPPLSSPLPEAP
S1645 SLTPEAFSLDSSLRG
S1649 EAFSLDSSLRGKQRM
R1651 FSLDSSLRGKQRMSK
S1657 LRGKQRMSKQNFLQA
R1671 AHNGQGLRAAQPTDD
Q1674 GQGLRAAQPTDDPLS
S1681 QPTDDPLSLLDPLWT
T1688 SLLDPLWTLNkT___
K1691-ub DPLWTLNkT______
T1692 PLWTLNkT_______
  rat

 
- gap
- gap
Y38 ISAQVVDYYKEACRA
K104 YFQSALDKLNEAIKL
K110 DKLNEAIKLAKGQPD
K113 NEAIKLAKGQPDTVQ
T118 LAKGQPDTVQDALRF
K165 VKGAPLVKPLPVNPT
K297 EDELQEQKLQETLGQ
- under review  
K327 EVRREWAKYTEVHEK
S336 TEVHEKASFTNSELH
T338 VHEKASFTNSELHRA
S340 EKASFTNSELHRAMN
K427 TDHSEMKKLFEEQLK
K427 TDHSEMKKLFEEQLK
K434 KLFEEQLKKYDQLKV
K435 LFEEQLKKYDQLKVY
K440 LKKYDQLKVYLEQNL
Y506 SQEGKDFYADLESKV
A520 VAALLERAQSLCRAQ
L523 LLERAQSLCRAQEAA
G561 LLSRREEGEAAEAGD
Q569 EAAEAGDQPEELRSL
S575 DQPEELRSLPPDMMA
R785 PTSFPAPRIGPQPPP
S984 AAAADLLSSsPESQH
S985 AAADLLSSsPESQHG
S986-p AADLLSSsPESQHGG
S989 LLSSsPESQHGGTQP
T994 PESQHGGTQPPGGGQ
P996 SQHGGTQPPGGGQPL
Y1028 RLIEQDPYEHPERLQ
Y1092 RHQDVMPYDSNRVVL
T1132 TQRPLPGTAADFWLM
S1153 SVIVMLVSEAEMEKQ
S1338 PVASMSVSQKSHLPQ
S1347 KSHLPQDSQDLVLGG
P1405 PEPTPAPPSSPPPPS
S1412 PSSPPPPSSPLPEPP
S1452 SLTPEAFSLDSSLRG
S1456 EAFSLDSSLRGKQRM
R1458 FSLDSSLRGKQRMSK
S1464 LRGKQRMSKQNFLQA
R1478 AHNGQGLRAAQPTDD
Q1481 GQGLRAAQPTDDPLS
S1488 QPTDDPLSLLDPLWT
T1495 SLLDPLWTLNKT___
K1498 DPLWTLNKT______
T1499 PLWTLNKT_______
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