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SRF (human)

Overview SRF a transcription factor of the MADS domain family that binds to the serum response element (SRE). Regulates the transcription of immediate early genes including c-fos. Binds DNA as a multimer, probably a dimer. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Transcription factor Cellular Component: nuclear chromatin; cytoplasm; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; chromatin DNA binding; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; developmental growth; erythrocyte development; heart development; response to toxin; cell-matrix adhesion; response to hormone stimulus; neuron migration; cardiac myofibril assembly; muscle maintenance; negative regulation of cell proliferation; tangential migration from the subventricular zone to the olfactory bulb; regulation of smooth muscle cell differentiation; morphogenesis of an epithelial sheet; positive regulation of smooth muscle contraction; heart looping; negative regulation of cell migration; neurite development; associative learning; positive thymic T cell selection; positive regulation of filopodium formation; regulation of cell adhesion; platelet activation; skin morphogenesis; hippocampus development; sarcomere organization; angiogenesis involved in wound healing; mRNA transcription from RNA polymerase II promoter; trophectodermal cell differentiation; regulation of water loss via skin; patterning of blood vessels; contractile actin filament bundle formation; long-term memory; cell migration during sprouting angiogenesis; mesoderm formation; response to cytokine stimulus; stress fiber formation; response to hypoxia; neuron development; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; platelet formation; positive regulation of cell differentiation Reference #:  P11831 (UniProtKB) Alt. Names/Synonyms: MCM1; Serum response factor; serum response factor (c-fos serum response element-binding transcription factor); SRF Gene Symbols: SRF Molecular weight: 51,593 Da Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SRF 1HBX - A/B/D/E=132-223 (human) 1K6O - B/C=133-235 (human) 1SRS - A/B=132-223 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HBX 1K6O 1SRS  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S103‑p, T159‑p, S162‑p, S251‑p, S253‑p activation: T159‑p molecular association, regulation: S83‑p, S85‑p, S103‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T4-p	____MLPtQAGAAAA
0	1		S16-p	AAALGRGsALGGSLN
0	1		T27-p	GSLNRTPtGRPGGGG
0	1		Y76	APTAGALYsGsEGDs
4	1		S77-p	PTAGALYsGsEGDsE
4	1		S79-p	AGALYsGsEGDsEsG
3	4		S83-p	YsGsEGDsEsGEEEE
3	3		S85-p	GsEGDsEsGEEEELG
1	3		S101-p	ERRGLKRsLsEMEIG
13	5		S103-p	RGLKRsLsEMEIGMV
1	0		K147-s	TRGRVKIkMEFIDNK
2	0		T159-p	DNKLRRYtTFsKRKT
2	0		S162-p	LRRYtTFsKRKTGIM
0	1		S176-p	MKKAYELstLTGTQV
0	1		T177-p	KKAYELstLTGTQVL
0	1		T199-p	GHVYTFAtRKLQPMI
0	1		S221-p	LIQTCLNsPDsPPRS
1	12		S224-p	TCLNsPDsPPRSDPT
1	0		S251-p	TDLTYQVsEsDSSGE
1	0		S253-p	LTYQVsEsDSSGETK
1	0		S277-g	TNLPGTTsTIQTAPS
1	0		S313-g	VSASVSPsAVsSANG
1	0		S316-g	SVSPsAVsSANGTVL
0	1		S370	HQAPQQASPSRDSST
1	0		S383-g	STDLTQTsSSGTVTL
1	0		T401-g	IMTSSVPtTVGGHMM
1	0		S435-p	LTVLNAFsQAPSTMQ
1	0		S446-p	STMQVSHsQVQEPGG

	mouse
S4	____MLPSQAGAAAA
S16	AAALGRGSALGGNLN
T27	GNLNRTPTGRPGGGG
Y72-p	APTAGALySGSEGDs
S73	PTAGALySGSEGDsE
S75	AGALySGSEGDsEsG
S79-p	ySGSEGDsEsGEEEE
S81-p	GSEGDsEsGEEEELG
S97-p	ERRGLKRsLsEMELG
S99-p	RGLKRsLsEMELGVV
K143	TRGRVKIKMEFIDNK
T155	DNKLRRYTTFSKRKT
S158	LRRYTTFSKRKTGIM
S172	MKKAYELSTLTGTQV
T173	KKAYELSTLTGTQVL
T195	GHVYTFATRKLQPMI
S217-p	LIQTCLNsPDsPPRS
S220-p	TCLNsPDsPPRSDPT
S247	PDLTYQVSESDSSGE
S249	LTYQVSESDSSGETK
S273	TNLPGTTSTIQTAPS
S309	VSASVSPSAVSSANG
S312	SVSPSAVSSANGTVL
S366-p	HQAPQQAsPSRDSST
S379	STDLTQTSSSGTVTL
T397	IMTSSVPTTVGGHMM
S431	LTVLNAFSQAPSTMQ
S442	STMQVSHSQVQEPGG

	rat
S4	____MLPSQAGAAAA
S16	AAALGRGSALGGSLN
T27	GSLNRTPTGRPGGSG
Y72	APTAGALYsGsEGDS
S73-p	PTAGALYsGsEGDSE
S75-p	AGALYsGsEGDSESG
S79	YsGsEGDSESGEEEE
S81	GsEGDSESGEEEELG
S97	ERRGLKRSLsEMELG
S99-p	RGLKRSLsEMELGVV
K143	TRGRVKIKMEFIDNK
T155	DNKLRRYTTFSKRKT
S158	LRRYTTFSKRKTGIM
S172	MKKAYELSTLTGTQV
T173	KKAYELSTLTGTQVL
T195	GHVYTFATRKLQPMI
S217	LIQTCLNSPDsPPRS
S220-p	TCLNSPDsPPRSDPS
S247	PDLTYQVSESDSSGE
S249	LTYQVSESDSSGETK
S273	TNLPGTTSTIQTAPS
S309	VSASVSPSAVSSANG
S312	SVSPSAVSSANGTVL
S366	HQAPQQASPSRDSST
S379	STDLTQTSSSGTVTL
T397	IMTSSVPTTVGGHMM
S431	LTVLNAFSQAPSTMQ
S442	STMQVSHSQVQEPGG

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