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JNK2
a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24; Protein kinase, CMGC; Kinase, protein; CMGC group; MAPK family; JNK subfamily; MAPK/JNK subfamily |
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Cellular Component: nucleoplasm; mitochondrion; cytosol
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Molecular Function: protein binding; JUN kinase activity; transcription factor binding; ATP binding
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Biological Process: MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; JUN phosphorylation; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to cadmium ion; regulation of transcription factor activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; response to stress; toll-like receptor 4 signaling pathway
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Reference #:
P45984 (UniProtKB)
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| Alt. Names/Synonyms: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; Jun kinase; MAP kinase 9; MAPK 9; MAPK9; Mitogen-activated protein kinase 9; mitogen-activated protein kinase 9 isoform JNK2 alpha2; MK09; p54a; p54aSAPK; PRKM9; SAPK; Stress-activated protein kinase JNK2 |
| Gene Symbols: MAPK9 |
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Molecular weight: 48,139 Da
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Basal Isoelectric point: 5.41
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis
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B Cell Receptor Signaling
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Death Receptor Signaling
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ErbB/HER Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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NF-kB Signaling
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Parkinson's Disease
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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