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Protein Page:
JNK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JNK2 a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.24; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; JNK subfamily; MAPK/JNK subfamily
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: nucleoplasm; mitochondrion; cytosol
Molecular Function: protein binding; caspase activator activity; mitogen-activated protein kinase kinase kinase binding; JUN kinase activity; transcription factor binding; ATP binding
Biological Process: positive regulation of nitric oxide biosynthetic process; central nervous system development; regulation of protein ubiquitination; positive regulation of apoptosis; response to toxin; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; regulation of JNK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; response to stress; JNK cascade; toll-like receptor 4 signaling pathway; protein targeting to mitochondrion; neurite development; positive regulation of prostaglandin biosynthetic process; response to drug; caspase activation; release of cytochrome c from mitochondria; MyD88-independent toll-like receptor signaling pathway; positive regulation of chemokine production; JUN phosphorylation; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to cadmium ion; response to mechanical stimulus; positive regulation of prostaglandin secretion; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of protein amino acid phosphorylation; response to amine stimulus; positive regulation of nitric-oxide synthase biosynthetic process
Reference #:  P45984 (UniProtKB)
Alt. Names/Synonyms: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; Jun kinase; MAP kinase 9; MAPK 9; MAPK9; Mitogen-activated protein kinase 9; mitogen-activated protein kinase 9 isoform JNK2 alpha2; MK09; p54a; p54aSAPK; PRKM9; SAPK; Stress-activated protein kinase JNK2
Gene Symbols: MAPK9
Molecular weight: 48,139 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JNK2

Protein Structure Not Found.

Substrate Sequence Logo
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 S129 ELDHERMSYLLYQML
0 3 K166-ub VKSDCTLkILDFGLA
0 2 T178-p GLARTACtNFMMtPy
57 435 T183-p ACtNFMMtPyVVtRY
58 1440 Y185-p tNFMMtPyVVtRYYR
0 28 T188-p MMtPyVVtRYYRAPE
0 1 K236 DHIDQWNKVIEQLGT
0 1 K250-ac TPSAEFMkKLQPTVR
0 2 K250-ub TPSAEFMkKLQPTVR
0 1 S292-p ERDKIKTsQARDLLS
0 1 K353-ub EHAIEEWkELIyKEV
0 1 Y357-p EEWkELIyKEVMDWE
1 0 T404-p SSMSTEQtLAsDTDS
1 0 S407-p STEQtLAsDTDSSLD
  JNK2 iso2  
S129 ELDHERMSYLLYQML
K166 VKSDCTLKILDFGLA
T178 GLARTACTNFMMTPy
T183 ACTNFMMTPyVVTRY
Y185-p TNFMMTPyVVTRYYR
T188 MMTPyVVTRYYRAPE
K236 DHIDQWNKVIEQLGT
K250 TPSAEFMKKLQPTVR
K250 TPSAEFMKKLQPTVR
S292 ERDKIKTSQARDLLS
K353 EHAIEEWKELIYKEV
Y357 EEWKELIYKEVMDWE
- gap
- gap
  JNK2 iso3  
S129 ELDHERMSYLLYQML
K166 VKSDCTLKILDFGLA
T178 GLARTACTNFMMTPY
T183 ACTNFMMTPYVVTRY
Y185 TNFMMTPYVVTRYYR
T188 MMTPYVVTRYYRAPE
K236-ub DYIDQWNkVIEQLGT
K250 TPSAEFMKKLQPTVR
K250 TPSAEFMKKLQPTVR
S292 ERDKIKTSQARDLLS
K353 EHAIEEWKELIYKEV
Y357 EEWKELIYKEVMDWE
- gap
- gap
  mouse

 
S129-p ELDHERMsYLLYQML
K166-ub VKSDCTLkILDFGLA
T178 GLARTACTNFMMtPy
T183-p ACTNFMMtPyVVtRY
Y185-p TNFMMtPyVVtRYYR
T188-p MMtPyVVtRYYRAPE
K236 DYIDQWNKVIEQLGT
K250 TPSAEFMKKLQPTVR
K250-ub TPSAEFMkKLQPTVR
S292 ERDKIKTSQARDLLS
K353 EHAIEEWKELIYKEV
Y357 EEWKELIYKEVMDWE
T403 SSMSTEHTLASDTDS
S406 STEHTLASDTDSSLD
  rat

 
S129 ELDHERMSYLLYQML
K166 VKSDCTLKILDFGLA
T178 GLARTACTNFMMtPy
T183-p ACTNFMMtPyVVTRY
Y185-p TNFMMtPyVVTRYYR
T188 MMtPyVVTRYYRAPE
K236 DHIDQWNKVIEQLGT
K250 TPSAEFMKKLQPTVR
K250 TPSAEFMKKLQPTVR
S292 ERDKIKTSQARDLLS
K353 EHAIEEWKELIYKEV
Y357 EEWKELIYKEVMDWE
T403 SSMSTEHTLASDTDS
S406 STEHTLASDTDSSLD
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