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Protein Page:
IRF2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRF2 Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 4q34.1-q35.1
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; blood coagulation
Reference #:  P14316 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F0244; Interferon regulatory factor 2; IRF-2; IRF2
Gene Symbols: IRF2
Molecular weight: 39,354 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRF2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K29-ac PGLKWLNkEkkIFQI
1 0 K31-ac LKWLNkEkkIFQIPW
1 0 K32-ac KWLNkEkkIFQIPWM
1 0 K75-ac GVDKPDPkTWkANFR
1 0 K78-ac KPDPkTWkANFRCAM
1 0 Y109 GNNAFRVYRMLPLSE
0 1 S119-p LPLSERPsKKGKKPK
1 0 K137-sm EDKVKHIkQEPVEss
0 1 S143-p IkQEPVEssLGLsNG
0 1 S144-p kQEPVEssLGLsNGV
0 1 S148-p VEssLGLsNGVSDLS
0 1 T162-p SPEYAVLtstIkNEV
0 1 S163-p PEYAVLtstIkNEVD
0 1 T164-p EYAVLtstIkNEVDS
1 0 K166-sm AVLtstIkNEVDSTV
0 1 S225-p ELYPLQIsPVSSYAE
0 1 S241-p ETTDSVPsDEESAEG
0 1 K285 ASFVTSNKPDLQVTI
1 0 K293-sm PDLQVTIkEESNPVP
  mouse

 
K29 PGLKWLNKEKKIFQI
K31 LKWLNKEKKIFQIPW
K32 KWLNKEKKIFQIPWM
K75 GIDKPDPKTWKANFR
K78 KPDPKTWKANFRCAM
Y109-p GNNAFRVyRMLPLSE
S119 LPLSERPSKKGKKPK
K137 EERVKHIKQEPVESS
S143 IKQEPVESSLGLSNG
S144 KQEPVESSLGLSNGV
S148 VESSLGLSNGVSGFS
T162 SPEYAVLTSAIKNEV
S163 PEYAVLTSAIKNEVD
A164 EYAVLTSAIKNEVDS
K166 AVLTSAIKNEVDSTV
S225 ELYPLQISPVSSYAE
S241 ETTDSVASDEENAEG
K285-ac ATFVTSNkPDLQVTI
K293 PDLQVTIKEDSCPMP
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