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Protein Page:
CD19 (human)

Overview
CD19 a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: receptor signaling protein activity
Biological Process: epidermal growth factor receptor signaling pathway; B cell receptor signaling pathway; regulation of immune response; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response
Reference #:  P15391 (UniProtKB)
Alt. Names/Synonyms: B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; B4; CD19; CD19 antigen; CD19 molecule; Differentiation antigen CD19; MGC12802; T-cell surface antigen Leu-12
Gene Symbols: CD19
Molecular weight: 61,128 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD19

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y348‑p, Y378‑p, Y409‑p, Y439‑p
molecular association, regulation: Y348‑p, Y378‑p, Y409‑p, Y439‑p, Y500‑p, Y531‑p
phosphorylation: Y409‑p, Y439‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S227 KGPKSLLSLELKDDR
0 5 T337-p TRRFFKVtPPPGSGP
0 1 P340 FFKVtPPPGSGPQNQ
1 18 Y348-p GSGPQNQyGNVLSLP
0 4 T356-p GNVLSLPtPTSGLGR
1 4 Y378-p LGGTAPSyGNPSSDV
2 0 Y409-p EEEEGEGyEEPDSEE
1 0 Y439-p LSQDGSGyENPEDEP
0 1 T475-p LTQPVARtMDFLSPH
0 2 S497-p REATSLGsQsyEDMR
0 4 S499-p ATSLGsQsyEDMRGI
5 17 Y500-p TSLGsQsyEDMRGIL
1 9 Y508-p EDMRGILyAAPQLRS
0 5 S530-p NHEEDADsyENMDNP
6 19 Y531-p HEEDADsyENMDNPD
3571 : Phospho-CD19 (Tyr531) Antibody
  mouse

 
S225-p RPNVSLLsLSLGGEH
T335 ARRFFKVTPPsGNGT
S338-p FFKVTPPsGNGTQNQ
Y346-p GNGTQNQyGNVLSLP
T354 GNVLSLPTSTSGQAH
Y376-p LGSVPGSyGNPRIQV
Y402-p LEEEGEAyEEPDSEE
Y432 VSQDGSGYENPEDEP
M468 LAQPVGRMMDFLSPH
S490 REASSLGSQSyEDMR
S492 ASSLGSQSyEDMRGI
Y493-p SSLGSQSyEDMRGIL
Y501 EDMRGILYAAPQLHS
S521-p SHEEDADsyENMDKS
Y522-p HEEDADsyENMDKSD
3571 : Phospho-CD19 (Tyr531) Antibody
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