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Protein Page:
CD19 (human)

Overview
CD19 a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: receptor signaling protein activity
Biological Process: epidermal growth factor receptor signaling pathway; regulation of immune response; B cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response
Reference #:  P15391 (UniProtKB)
Alt. Names/Synonyms: B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; B4; CD19; CD19 antigen; CD19 molecule; Differentiation antigen CD19; MGC12802; T-cell surface antigen Leu-12
Gene Symbols: CD19
Molecular weight: 61,128 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD19

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y348‑p, Y378‑p, Y409‑p, Y439‑p
molecular association, regulation: Y348‑p, Y378‑p, Y409‑p, Y439‑p, Y500‑p, Y531‑p
phosphorylation: Y409‑p, Y439‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S227 KGPKSLLSLELKDDR
0 5 T337-p TRRFFKVtPPPGSGP
0 1 P340 FFKVtPPPGSGPQNQ
1 18 Y348-p GSGPQNQyGNVLSLP
0 4 T356-p GNVLSLPtPTSGLGR
1 4 Y378-p LGGTAPSyGNPSSDV
2 0 Y409-p EEEEGEGyEEPDSEE
1 0 Y439-p LSQDGSGyENPEDEP
0 1 T475-p LTQPVARtMDFLSPH
0 2 S497-p REATSLGsQsyEDMR
0 4 S499-p ATSLGsQsyEDMRGI
5 17 Y500-p TSLGsQsyEDMRGIL
1 9 Y508-p EDMRGILyAAPQLRS
0 6 S530-p NHEEDADsyENMDNP
6 19 Y531-p HEEDADsyENMDNPD
3571 : Phospho-CD19 (Tyr531) Antibody
  mouse

 
S225-p RPNVSLLsLSLGGEH
T335 ARRFFKVTPPsGNGT
S338-p FFKVTPPsGNGTQNQ
Y346-p GNGTQNQyGNVLSLP
T354 GNVLSLPTSTSGQAH
Y376-p LGSVPGSyGNPRIQV
Y402-p LEEEGEAyEEPDSEE
Y432 VSQDGSGYENPEDEP
M468 LAQPVGRMMDFLSPH
S490 REASSLGSQSyEDMR
S492 ASSLGSQSyEDMRGI
Y493-p SSLGSQSyEDMRGIL
Y501 EDMRGILYAAPQLHS
S521-p SHEEDADsyENMDKS
Y522-p HEEDADsyENMDKSD
3571 : Phospho-CD19 (Tyr531) Antibody
  rat

 
S225 TLNVSLLSLSLGGEH
T335 ARRFFKVTPPSGNGT
S338 FFKVTPPSGNGTQNQ
Y346 GNGTQNQYGNVLSLP
T354 GNVLSLPTSTSGQAH
Y376 LGSGPVSYGNPRIEV
Y402 LEEEGEAYEEPDSEE
Y432 LSQDGSGYENPEDDP
T468 LAQPVGRTMDFLSPH
S490 REASSLGSQSYEDMR
S492 ASSLGSQSYEDMRGI
Y493 SSLGSQSYEDMRGIL
Y501 EDMRGILYAAPQLQS
S521-p SHEEDADsYENMDKS
Y522 HEEDADsYENMDKSD
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