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CD19 (human)

Overview CD19 a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cell surface Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function: receptor signaling protein activity Biological Process: regulation of immune response; cell surface receptor linked signal transduction; cellular defense response Reference #:  P15391 (UniProtKB) Alt. Names/Synonyms: B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; B4; CD19; CD19 antigen; CD19 molecule; Differentiation antigen CD19; MGC12802; T-cell surface antigen Leu-12 Gene Symbols: CD19 Molecular weight: 61,128 Da Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CD19

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	Sites Implicated In
activation: Y348‑p, Y378‑p, Y409‑p, Y439‑p molecular association, regulation: Y348‑p, Y378‑p, Y409‑p, Y439‑p, Y500‑p, Y531‑p phosphorylation: Y409‑p, Y439‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S227	KGPKSLLSLELKDDR
0	5		T337-p	TRRFFKVtPPPGSGP
0	1		P340	FFKVtPPPGSGPQNQ
1	18		Y348-p	GSGPQNQyGNVLSLP
0	4		T356-p	GNVLSLPtPTSGLGR
1	4		Y378-p	LGGTAPSyGNPSSDV
2	0		Y409-p	EEEEGEGyEEPDSEE
1	0		Y439-p	LSQDGSGyENPEDEP
0	1		T475-p	LTQPVARtMDFLSPH
0	2		S497-p	REATSLGsQsyEDMR
0	4		S499-p	ATSLGsQsyEDMRGI
5	17		Y500-p	TSLGsQsyEDMRGIL
1	9		Y508-p	EDMRGILyAAPQLRS
0	5		S530-p	NHEEDADsyENMDNP
6	19		Y531-p	HEEDADsyENMDNPD

	mouse
S225-p	RPNVSLLsLSLGGEH
T335	ARRFFKVTPPsGNGT
S338-p	FFKVTPPsGNGTQNQ
Y346-p	GNGTQNQyGNVLSLP
T354	GNVLSLPTSTSGQAH
Y376-p	LGSVPGSyGNPRIQV
Y402-p	LEEEGEAyEEPDSEE
Y432	VSQDGSGYENPEDEP
M468	LAQPVGRMMDFLSPH
S490	REASSLGSQSyEDMR
S492	ASSLGSQSyEDMRGI
Y493-p	SSLGSQSyEDMRGIL
Y501	EDMRGILYAAPQLHS
S521-p	SHEEDADsyENMDKS
Y522-p	HEEDADsyENMDKSD

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