General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Acetyltransferase; Transcription factor
Chromosomal Location of Human Ortholog: 1p22-p21
Cellular Component: nucleoplasm
Molecular Function: protein binding; zinc ion binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; RNA elongation from RNA polymerase II promoter; gene expression
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.