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GTF2B (human)

Overview GTF2B General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Acetyltransferase Cellular Component: nucleoplasm Molecular Function: protein binding; DNA binding; zinc ion binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; virus-host interaction; RNA elongation from RNA polymerase II promoter; gene expression Reference #:  Q00403 (UniProtKB) Alt. Names/Synonyms: general transcription factor IIB; General transcription factor TFIIB; GTF2B; RNA polymerase II transcription factor IIB; S300-II; TF2B; TFIIB; Transcription initiation factor IIB Gene Symbols: GTF2B Molecular weight: 34,833 Da Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GTF2B 1C9B - A/E/I/M/Q=110-316 (human) 1DL6 - A=2-59 (human) 1RLY - A=1-60 (human) 1RO4 - A=1-60 (human) 1TFB - A=112-316 (human) 1VOL - A=113-316 (human) 2PHG - A=112-316 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S65‑p, K238‑a molecular association, regulation: S65‑p, K238‑a

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S65-p	DKATKDPsRVGDsQN
0	2		S70-p	DPsRVGDsQNPLLsD
0	2		S76-p	DsQNPLLsDGDLSTM
0	1		K86-u	DLSTMIGkGTGAASF
0	5		K100-u	FDEFGNSkYQNRRTM
0	2		K119-u	RAMMNAFkEITtMAD
0	1		T123-p	NAFkEITtMADRINL
0	1		K143-u	DRTNNLFkQVYEQKS
0	1		D207-ca	KALETSVdLITTGDF
1	1		K238-a	AATHIARkAVELDLV
0	1		T270-p	QASAEKRtQKEIGDI
0	1		T284-p	IAGVADVtIRQSYRL
0	1		Y293-p	RQSYRLIyPRAPDLF
0	2		K305-u	DLFPTDFkFDTPVDk
0	1		K312-u	kFDTPVDkLPQL___

	mouse
S65	DKATKDPSRVGDSQN
S70	DPSRVGDSQNPLLSD
S76	DSQNPLLSDGDLSTM
K86	DLSTMIGKGTGAASF
K100-u	FDEFGNSkYQNRRTM
K119-u	RAMMNAFkEITTMAD
T123	NAFkEITTMADRINL
K143	DRTNNLFKQVYEQKS
D207	KALETSVDLITTGDF
K238	AATHIARKAVELDLV
T270	QASAEKRTQKEIGDI
T284	IAGVADVTIRQSYRL
Y293	RQSYRLIYPRAPDLF
K305	DLFPSDFKFDTPVDK
K312	KFDTPVDKLPQL___

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