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Protein Page:
GTF2B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GTF2B General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Acetyltransferase
Cellular Component: nucleoplasm
Molecular Function: protein binding; zinc ion binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; RNA elongation from RNA polymerase II promoter; gene expression
Reference #:  Q00403 (UniProtKB)
Alt. Names/Synonyms: general transcription factor IIB; General transcription factor TFIIB; GTF2B; RNA polymerase II transcription factor IIB; S300-II; TF2B; TFIIB; Transcription initiation factor IIB
Gene Symbols: GTF2B
Molecular weight: 34,833 Da
Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GTF2B

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: K238‑a
transcription, induced: S65‑p
molecular association, regulation: S65‑p, K238‑a

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MAsTSRLDAL
1 1 S65-p DKATKDPsRVGDsQN
0 3 S70-p DPsRVGDsQNPLLsD
0 3 S76-p DsQNPLLsDGDLSTM
0 1 K86-u DLSTMIGkGTGAAsF
0 1 S92-p GkGTGAAsFDEFGNS
0 5 K100-u FDEFGNSkYQNRRTM
0 2 K119-u RAMMNAFkEITTMAD
0 1 K143-u DRTNNLFkQVYEQKS
0 1 D207-ca KALETSVdLITTGDF
1 1 K238-a AATHIARkAVELDLV
0 1 Y293-p RQSYRLIyPRAPDLF
0 2 K305-u DLFPTDFkFDTPVDk
0 1 K312-u kFDTPVDkLPQL___
  mouse

 
S3 _____MASTSRLDAL
S65 DKATKDPSRVGDSQN
S70 DPSRVGDSQNPLLSD
S76 DSQNPLLSDGDLSTM
K86 DLSTMIGKGTGAASF
S92 GKGTGAASFDEFGNS
K100-u FDEFGNSkYQNRRTM
K119-u RAMMNAFkEITTMAD
K143 DRTNNLFKQVYEQKS
D207 KALETSVDLITTGDF
K238 AATHIARKAVELDLV
Y293 RQSYRLIYPRAPDLF
K305 DLFPSDFKFDTPVDK
K312 KFDTPVDKLPQL___
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