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ADRB2
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral |
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Cellular Component: axon; integral to plasma membrane; lysosome; apical plasma membrane; plasma membrane; dendritic spine; caveola; nucleus; endosome; receptor complex; sarcolemma
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Molecular Function: ionotropic glutamate receptor binding; protein binding; potassium channel regulator activity; protein homodimerization activity; dopamine binding; beta2-adrenergic receptor activity; norepinephrine binding; drug binding; epinephrine binding; adenylate cyclase binding
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Biological Process: diet induced thermogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); wound healing; positive regulation of apoptosis; positive regulation of potassium ion transport; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; negative regulation of smooth muscle contraction; diaphragm contraction; positive regulation of cell proliferation; negative regulation of ossification; endosome to lysosome transport; bone resorption; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; synaptic transmission, glutamatergic; negative regulation of multicellular organism growth; adenylate cyclase activation; positive regulation of bone mineralization; G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of the force of heart contraction by epinephrine; positive regulation of protein ubiquitination; negative regulation of inflammatory response; heat generation; brown fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; response to cold; positive regulation of skeletal muscle growth; regulation of excitatory postsynaptic membrane potential; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
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Reference #:
P07550 (UniProtKB)
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| Alt. Names/Synonyms: ADRB2; ADRB2R; ADRBR; adrenergic, beta-2-, receptor, surface; B2AR; BAR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; catecholamine receptor |
| Gene Symbols: ADRB2 |
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Molecular weight: 46,459 Da
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Basal Isoelectric point: 6.59
Predict pI for various phosphorylation states
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