Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: integral to plasma membrane; axon; lysosome; apical plasma membrane; dendritic spine; plasma membrane; nucleus; sarcolemma; endosome; receptor complex
Molecular Function: ionotropic glutamate receptor binding; protein binding; potassium channel regulator activity; protein homodimerization activity; protein complex binding; dopamine binding; G-protein alpha-subunit binding; beta2-adrenergic receptor activity; norepinephrine binding; drug binding; epinephrine binding; B2 bradykinin receptor binding; adenylate cyclase binding
Biological Process: diet induced thermogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); wound healing; positive regulation of apoptosis; positive regulation of potassium ion transport; female pregnancy; positive regulation of vasodilation; cell surface receptor linked signal transduction; cell-cell signaling; positive regulation of MAPKKK cascade; negative regulation of smooth muscle contraction; diaphragm contraction; positive regulation of cell proliferation; negative regulation of ossification; endosome to lysosome transport; associative learning; aging; bone resorption; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; synaptic transmission, glutamatergic; receptor-mediated endocytosis; negative regulation of multicellular organism growth; adenylate cyclase activation; response to testosterone stimulus; regulation of calcium ion transport; positive regulation of bone mineralization; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of angiogenesis; positive regulation of the force of heart contraction by epinephrine; positive regulation of ATPase activity; positive regulation of protein ubiquitination; response to estrogen stimulus; heat generation; negative regulation of inflammatory response; brown fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; response to cold; response to progesterone stimulus; positive regulation of skeletal muscle growth; regulation of excitatory postsynaptic membrane potential; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.