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Protein Page:
H2AZ (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
H2AZ Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: Barr body; nuclear heterochromatin; nucleosome; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; protein heterodimerization activity; chromatin DNA binding
Biological Process: nucleosome assembly; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P0C0S5 (UniProtKB)
Alt. Names/Synonyms: H2A histone family, member Z; H2A.z; H2A/z; H2AFZ; H2AZ; H2AZ histone; Histone H2A.Z; MGC117173
Gene Symbols: H2AFZ
Molecular weight: 13,553 Da
Basal Isoelectric point: 10.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

H2AZ

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 254 K5-ac ___MAGGkAGkDSGk
5 414 K8-ac MAGGkAGkDSGkAkT
4 408 K12-ac kAGkDSGkAkTkAVS
1 293 K14-ac GkDSGkAkTkAVSRS
0 1 K14-ub GkDSGkAkTkAVSRS
1 0 K16 DSGkAkTKAVSRSQR
0 5 K16-ub DSGkAkTkAVSRSQR
0 3 Y61-p YSAAILEyLTAEVLE
0 17 K75-ub ELAGNASkDLkVKRI
0 2 K78-ub GNASkDLkVKRITPR
1 16 K116-ub GVIPHIHkSLIGkkG
0 1 K121 IHkSLIGKkGQQkTV
0 97 K121-ub IHkSLIGkkGQQkTV
1 89 K122-ub HkSLIGkkGQQkTV_
0 84 K126-ub IGkkGQQkTV_____
  mouse

 
K5-ac ___MAGGkAGkDSGk
K8-ac MAGGkAGkDSGkAkT
K12-ac kAGkDSGkAkTKAVS
K14-ac GkDSGkAkTKAVSRS
K14 GkDSGkAKTKAVSRS
K16 DSGkAkTKAVSRSQR
K16 DSGkAkTKAVSRSQR
Y61 YSAAILEYLTAEVLE
K75-ub ELAGNASkDLkVKRI
K78-ub GNASkDLkVKRITPR
K116-ub GVIPHIHkSLIGkkG
K121-ac IHkSLIGkkGQQkTV
K121-ub IHkSLIGkkGQQkTV
K122-ub HkSLIGkkGQQkTV_
K126-ub IGkkGQQkTV_____
  rat

 
K5-ac ___MAGGkAGkDSGk
K8-ac MAGGkAGkDSGkAkT
K12-ac kAGkDSGkAkTKAVS
K14-ac GkDSGkAkTKAVSRS
K14 GkDSGkAKTKAVSRS
K16 DSGkAkTKAVSRSQR
K16 DSGkAkTKAVSRSQR
Y61 YSAAILEYLTAEVLE
K75 ELAGNASKDLKVKRI
K78 GNASKDLKVKRITPR
K116 GVIPHIHKSLIGkkG
K121 IHKSLIGKkGQQKTV
K121-ub IHKSLIGkkGQQKTV
K122-ub HKSLIGkkGQQKTV_
K126 IGkkGQQKTV_____
  chicken

 
K5-ac ___MAGGkAGkDSGk
K8-ac MAGGkAGkDSGkTkT
K12-ac kAGkDSGkTkTkAVS
K14-ac GkDSGkTkTkAVSRS
K14 GkDSGkTKTkAVSRS
K16-ac DSGkTkTkAVSRSQR
K16 DSGkTkTKAVSRSQR
Y61 YSAAILEYLTAEVLE
K75 ELAGNASKDLKVKRI
K78 GNASKDLKVKRITPR
K116 GVIPHIHKSLIGKKG
K121 IHKSLIGKKGQQKTV
K121 IHKSLIGKKGQQKTV
K122 HKSLIGKKGQQKTV_
K126 IGKKGQQKTV_____
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