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Protein Page:
DNAJC5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNAJC5 a cysteine string protein that inhibits N-type calcium channels which is blocked by huntingtin mutants. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Modulates the maturation of cystic fibrosis transmembrane conductance regulator. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: synaptic vesicle; membrane; mitochondrion; lysosomal membrane; plasma membrane; melanosome
Molecular Function: ATP-dependent protein binding; glycoprotein binding
Biological Process: cell death; synaptic transmission; neurotransmitter secretion; negative regulation of neuron apoptosis
Reference #:  Q9H3Z4 (UniProtKB)
Alt. Names/Synonyms: CSP; Cysteine string protein; DKFZp434N1429; DKFZp761N1221; DnaJ (Hsp40) homolog, subfamily C, member 5; DnaJ homolog subfamily C member 5; DNAJC5; DNAJC5A; DNJC5; FLJ00118; FLJ13070
Gene Symbols: DNAJC5
Molecular weight: 22,149 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Select Structure to View Below

DNAJC5

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S10‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 122 S8-p MADQRQRsLstsGEs
4 383 S10-p DQRQRsLstsGEsLy
0 59 T11-p QRQRsLstsGEsLyH
0 22 S12-p RQRsLstsGEsLyHV
0 28 S15-p sLstsGEsLyHVLGL
0 12 Y17-p stsGEsLyHVLGLDK
0 1 S34-p TSDDIKKsYRKLALk
0 7 K41-ub sYRKLALkyHPDkNP
0 1 Y42-p YRKLALkyHPDkNPD
0 1 K46-ub ALkyHPDkNPDNPEA
0 1 K56-ac DNPEAADkFkEINNA
0 2 K56-ub DNPEAADkFkEINNA
0 2 K58-ub PEAADkFkEINNAHA
0 5 K72-ub AILTDATkRNIYDKY
0 7 Y149-p EGEETEFyVSPEDLE
0 3 S151 EETEFyVSPEDLEAQ
0 1 S161 DLEAQLQSDEREATD
1 1 T169 DEREATDTPIVIQPA
0 8 Y192-p TADSHPSyHTDGFN_
  mouse

 
S8-p MADQRQRsLstsGEs
S10-p DQRQRsLstsGEsLy
T11-p QRQRsLstsGEsLyH
S12-p RQRsLstsGEsLyHV
S15-p sLstsGEsLyHVLGL
Y17-p stsGEsLyHVLGLDK
S34 TSDDIKKSYRKLALk
K41-ub SYRKLALkYHPDKNP
Y42 YRKLALkYHPDKNPD
K46 ALkYHPDKNPDNPEA
K56 DNPEAADKFkEINNA
K56-ub DNPEAADkFkEINNA
K58-ub PEAADkFkEINNAHA
K72-ub AILTDATkRNIYDKY
Y149 EGEETEFYVsPEDLE
S151-p EETEFYVsPEDLEAQ
S161-p DLEAQLQsDEREATD
T169 DEREATDTPIVIQPA
Y192 TADSHPSYHTDGFN_
  rat

 
S8-p MADQRQRsLsTSGES
S10-p DQRQRsLsTSGESLY
T11 QRQRsLsTSGESLYH
S12 RQRsLsTSGESLYHV
S15 sLsTSGESLYHVLGL
Y17 sTSGESLYHVLGLDK
S34 TSDDIKKSYRKLALk
K41-ub SYRKLALkYHPDKNP
Y42 YRKLALkYHPDKNPD
K46 ALkYHPDKNPDNPEA
K56 DNPEAADKFKEINNA
K56 DNPEAADKFKEINNA
K58 PEAADKFKEINNAHA
K72 AILTDATKRNIYDKY
Y149 EGEETEFYVSPEDLE
S151 EETEFYVSPEDLEAQ
S161 DLEAQLQSDEREATD
T169-p DEREATDtPIVIQPA
Y192 TADSHPSYHTDGFN_
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