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Protein Page:
SHP-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SHP-1 an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Cellular Component: membrane; cytoplasm; alpha-beta T cell receptor complex; nucleus; cytosol
Molecular Function: protein binding; phosphotyrosine binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; protein kinase binding; SH3 domain binding
Biological Process: negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine phosphorylation; natural killer cell mediated cytotoxicity; apoptosis; cytokine and chemokine mediated signaling pathway; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation; positive regulation of phosphoinositide 3-kinase cascade; negative regulation of humoral immune response mediated by circulating immunoglobulin; G-protein coupled receptor protein signaling pathway; cell proliferation; negative regulation of cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; regulation of B cell differentiation; T cell costimulation; positive regulation of cell proliferation; blood coagulation; cell differentiation; leukocyte migration
Reference #:  P29350 (UniProtKB)
Alt. Names/Synonyms: HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols: PTPN6
Molecular weight: 67,561 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHP-1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y536‑p, Y564‑p
molecular association, regulation: Y536‑p, Y564‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 8 S10-p RWFHRDLsGLDAETL
0 6 K19-u LDAETLLkGRGVHGs
0 1 S26-p kGRGVHGsFLARPSR
0 2 S57 THIRIQNSGDFyDLy
0 29 Y61-p IQNSGDFyDLyGGEK
0 37 Y64-p SGDFyDLyGGEKFAT
0 3 Y98-p GTIIHLKyPLNCSDP
0 4 S186-p GGLETFDsLtDLVEH
0 3 T188-p LETFDsLtDLVEHFK
1 0 Y208 EASGAFVYLRQPyyA
0 3 Y213-p FVYLRQPyyATRVNA
0 4 Y214-p VYLRQPyyATRVNAA
0 3 S250-p GFWEEFEsLQKQEVK
0 8 Y276-p ENKGKNRykNILPFD
0 1 K277-a NKGKNRykNILPFDH
0 1 K277-u NKGKNRykNILPFDH
0 2 S299-p RDSNIPGsDyINANy
0 66 Y301-p SNIPGsDyINANyIK
0 9 Y306-p sDyINANyIKNQLLG
0 3 Y374-p EVGMQRAyGPySVTN
0 8 Y377-p MQRAyGPySVTNCGE
0 1 Y390-p GEHDTTEykLRTLQV
0 4 K391-u EHDTTEykLRTLQVs
0 3 S398-p kLRTLQVsPLDNGDL
0 1 Y509-p EAQYKFIyVAIAQFI
0 3 S528-p KKLEVLQsQKGQEsE
0 81 S534-p QsQKGQEsEyGNIty
10 638 Y536-p QKGQEsEyGNItyPP
0 22 T540-p EsEyGNItyPPAMKN
0 225 Y541-p sEyGNItyPPAMKNA
0 2 S553-p KNAHAKAsRtssKHK
0 4 T555-p AHAKAsRtssKHKED
0 5 S556-p HAKAsRtssKHKEDV
0 57 S557-p AKAsRtssKHKEDVy
6 748 Y564-p sKHKEDVyENLHTKN
0 3 S582-p EKVKKQRsADKEKsK
0 2 S588-p RsADKEKsKGsLKRK
5 15 S591-p DKEKsKGsLKRK___
8849 : Phospho-SHP-1 (Tyr564) (D11G5) Rabbit mAb
  SHP-1 iso5  
S10 RWFHRDLSGLDAETL
K19 LDAETLLKGRGVHGS
S26 KGRGVHGSFLARPSR
S57 THIRIQNSGDFYDLY
Y61 IQNSGDFYDLYGGEK
Y64 SGDFYDLYGGEKFAT
Y98 GTIIHLKYPLNCSDP
S186 GGLETFDSLTDLVEH
T188 LETFDSLTDLVEHFK
Y208 EASGAFVYLRQPYYA
Y213 FVYLRQPYYATRVNA
Y214 VYLRQPYYATRVNAA
S250 GFWEEFESLQKQEVK
Y276 ENKGKNRYKNILPFD
K277 NKGKNRYKNILPFDH
K277 NKGKNRYKNILPFDH
S299 RDSNIPGSDYINANY
Y301 SNIPGSDYINANYIK
Y306 SDYINANYIKNQLLG
Y374 EVGMQRAYGPYSVTN
Y377 MQRAYGPYSVTNCGE
Y390 GEHDTTEYKLRTLQV
K391 EHDTTEYKLRTLQVS
S398 KLRTLQVSPLDNGDL
Y509 EAQYKFIYVAIAQFI
S528 KKLEVLQSQKGQESE
S534 QSQKGQESEYGNITY
Y536 QKGQESEYGNITYPP
T540 ESEYGNITYPPAMKN
Y541 SEYGNITYPPAMKNA
S553 KNAHAKASRTSSKSL
T555 AHAKASRTSSKSLES
S556 HAKASRTSSKSLESS
S557 AKASRTSSKSLESSA
- gap
- gap
- gap
- gap
  mouse

 
S10-p RWFHRDLsGPDAETL
K19 PDAETLLKGRGVPGS
S26 KGRGVPGSFLARPSR
S57-p THIRIQNsGDFYDLy
Y61 IQNsGDFYDLyGGEK
Y64-p sGDFYDLyGGEKFAT
Y98-p GTIIHLKyPLNCSDP
S186 GGSETFDSLtDLVEH
T188-p SETFDSLtDLVEHFK
Y208-p EASGAFVyLRQPyyA
Y213-p FVyLRQPyyATRVNA
Y214-p VyLRQPyyATRVNAA
S250 GFWEEFESLQKQEVK
Y276 ENKSKNRYKNILPFD
K277 NKSKNRYKNILPFDH
K277 NKSKNRYKNILPFDH
S299 RDSNIPGSDYINANY
Y301 SNIPGSDYINANYVK
Y306 SDYINANYVKNQLLG
Y374 EVGTQRVYGLySVTN
Y377-p TQRVYGLySVTNSRE
Y390 REHDTAEYkLRTLQI
K391-u EHDTAEYkLRTLQIS
S398 kLRTLQISPLDNGDL
Y509 EAQYKFIYVAIAQFI
S528 KKLEIIQSQKGQEsE
S534-p QSQKGQEsEyGNITy
Y536-p QKGQEsEyGNITyPP
T540 EsEyGNITyPPAVRS
Y541-p sEyGNITyPPAVRSA
S553 RSAHAKASRTSsKHK
T555 AHAKASRTSsKHKEE
S556 HAKASRTSsKHKEEV
S557-p AKASRTSsKHKEEVy
Y564-p sKHKEEVyENVHSKS
S582 EKVKKQRSADKEKNK
N588 RSADKEKNKGsLKRK
S591-p DKEKNKGsLKRK___
8849 : Phospho-SHP-1 (Tyr564) (D11G5) Rabbit mAb
  rat

 
S12-p GWFHRDLsGPDAETL
K21 PDAETLLKGRGVPGS
S28 KGRGVPGSFLARPSR
S59 THIRIQNSGDFYDLY
Y63 IQNSGDFYDLYGGEK
Y66 SGDFYDLYGGEKFAT
Y100 GTIIHLKYPLNCSDP
S188 GGSETFDSLTDLVEH
T190 SETFDSLTDLVEHFK
Y210 EASGAFVYLRQPYYA
Y215 FVYLRQPYYATRVNA
Y216 VYLRQPYYATRVNAA
S252 GFWEEFESLQKQEAK
Y278 ENKSKNRYKNILPFD
K279 NKSKNRYKNILPFDH
K279 NKSKNRYKNILPFDH
S301 RDSNIPGSDYINANY
Y303 SNIPGSDYINANYVK
Y308 SDYINANYVKNQLLG
Y376 EVGTQRVYGLYSVTN
Y379 TQRVYGLYSVTNCKE
Y392 KEHDTAEYKLRTLQI
K393 EHDTAEYKLRTLQIS
S400 KLRTLQISPLDNGDL
Y511 EAQYKFIYVAIAQFI
S530 KKLEIIQSQRGQESE
S536 QSQRGQESEyGNITY
Y538-p QRGQESEyGNITYPP
T542 ESEyGNITYPPALRS
Y543 SEyGNITYPPALRSA
S555 RSAHAKASRTSSKHK
T557 AHAKASRTSSKHKEE
S558 HAKASRTSSKHKEEV
S559 AKASRTSSKHKEEVY
Y566 SKHKEEVYENVHSKN
S584 EKVKKQRSADKEKNK
N590 RSADKEKNKGSLKRN
S593 DKEKNKGSLKRNISL
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