an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 188.8.131.52
Molecular Function: protein binding; phosphotyrosine binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; protein kinase binding; SH3 domain binding
Biological Process: negative regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid dephosphorylation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of B cell receptor signaling pathway; positive regulation of cell proliferation; abortive mitotic cell cycle; cell differentiation; negative regulation of peptidyl-tyrosine phosphorylation; natural killer cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; negative regulation of T cell receptor signaling pathway; positive regulation of cell adhesion mediated by integrin; regulation of release of sequestered calcium ion into cytosol; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; cell proliferation; regulation of B cell differentiation; T cell costimulation; platelet formation; blood coagulation; leukocyte migration
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.