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Protein Page:
SHP-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHP-1 an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Cellular Component: membrane; cytoplasm; nucleolus; alpha-beta T cell receptor complex; cytosol; nucleus
Molecular Function: protein binding; phosphotyrosine binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; protein kinase binding; SH3 domain binding
Biological Process: negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine phosphorylation; apoptosis; natural killer cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation; positive regulation of phosphoinositide 3-kinase cascade; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; positive regulation of cell proliferation; T cell costimulation; regulation of B cell differentiation; cell differentiation; blood coagulation; leukocyte migration
Reference #:  P29350 (UniProtKB)
Alt. Names/Synonyms: HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols: PTPN6
Molecular weight: 67,561 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHP-1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y536‑p, Y564‑p
molecular association, regulation: Y536‑p, Y564‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 9 S10-p RWFHRDLsGLDAETL
0 6 K19-ub LDAETLLkGRGVHGs
0 1 S26-p kGRGVHGsFLARPSR
0 3 S57 THIRIQNSGDFyDLy
0 26 Y61-p IQNSGDFyDLyGGEK
0 34 Y64-p SGDFyDLyGGEKFAT
0 3 Y98-p GTIIHLKyPLNCSDP
0 1 Y111-p DPTSERWyHGHMSGG
0 1 Y176-p VMCEGGRytVGGLET
0 1 T177-p MCEGGRytVGGLETF
0 4 S186-p GGLETFDsLtDLVEH
0 3 T188-p LETFDsLtDLVEHFK
1 0 Y208 EASGAFVYLRQPyyA
0 3 Y213-p FVYLRQPyyATRVNA
0 5 Y214-p VYLRQPyyATRVNAA
0 3 S250-p GFWEEFEsLQKQEVK
0 30 Y276-p ENKGKNRykNILPFD
0 1 K277-ac NKGKNRykNILPFDH
0 1 K277-ub NKGKNRykNILPFDH
0 2 S299-p RDSNIPGsDyINANy
0 69 Y301-p SNIPGsDyINANyIk
0 9 Y306-p sDyINANyIkNQLLG
0 1 K308-ub yINANyIkNQLLGPD
0 1 Y364-p GRNKCVPyWPEVGMQ
0 2 Y374-p EVGMQRAyGPysVTN
0 7 Y377-p MQRAyGPysVTNCGE
0 1 S378-p QRAyGPysVTNCGEH
0 1 Y390-p GEHDTTEykLRtLQV
0 4 K391-ub EHDTTEykLRtLQVs
0 1 T394-p TTEykLRtLQVsPLD
0 3 S398-p kLRtLQVsPLDNGDL
0 1 S496-p QMVRAQRsGMVQTEA
0 2 Y509-p EAQYKFIyVAIAQFI
0 3 S528-p KKLEVLQsQKGQEsE
0 88 S534-p QsQKGQEsEyGNIty
11 629 Y536-p QKGQEsEyGNItyPP
0 23 T540-p EsEyGNItyPPAMKN
1 206 Y541-p sEyGNItyPPAMKNA
0 2 S553-p KNAHAKAsRtssKHK
0 4 T555-p AHAKAsRtssKHKED
0 6 S556-p HAKAsRtssKHKEDV
0 65 S557-p AKAsRtssKHKEDVy
6 764 Y564-p sKHKEDVyENLHTKN
0 1 T569 DVyENLHTKNKREEK
0 3 S582-p EKVKKQRsADKEKsK
0 2 S588-p RsADKEKsKGsLKRK
5 15 S591-p DKEKsKGsLKRK___
0 1 - gap
8849 : Phospho-SHP-1 (Tyr564) (D11G5) Rabbit mAb
  SHP-1 iso4  
S10 RWFHRDLSGLDAETL
K19 LDAETLLKGRGVHGS
S26 KGRGVHGSFLARPSR
S57 THIRIQNSGDFYDLY
Y61 IQNSGDFYDLYGGEK
Y64 SGDFYDLYGGEKFAT
Y98 GTIIHLKYPLNCSDP
Y111 DPTSERWYHGHMSGG
Y176 VMCEGGRYTVGGLET
T177 MCEGGRYTVGGLETF
S186 GGLETFDSLTDLVEH
T188 LETFDSLTDLVEHFK
Y208 EASGAFVYLRQPYYA
Y213 FVYLRQPYYATRVNA
Y214 VYLRQPYYATRVNAA
S250 GFWEEFESLQKQEVK
Y276 ENKGKNRYKNILPFD
K277 NKGKNRYKNILPFDH
K277 NKGKNRYKNILPFDH
S299 RDSNIPGSDYINANY
Y301 SNIPGSDYINANYIK
Y306 SDYINANYIKNQLLG
K308 YINANYIKNQLLGPD
Y364 GRNKCVPYWPEVGMQ
Y374 EVGMQRAYGPYSVTN
Y377 MQRAYGPYSVTNCGE
S378 QRAYGPYSVTNCGEH
Y390 GEHDTTEYKLRTLQV
K391 EHDTTEYKLRTLQVS
T394 TTEYKLRTLQVSPLD
S398 KLRTLQVSPLDNGDL
S496 QMVRAQRSGMVQTEA
Y509 EAQYKFIYVAIAQFI
S528 KKLEVLQSQKGQESE
S534 QSQKGQESEYGNITY
Y536 QKGQESEYGNITYPP
T540 ESEYGNITYPPAMKN
Y541 SEYGNITYPPAMKNA
S553 KNAHAKASRTSSKSL
T555 AHAKASRTSSKSLES
S556 HAKASRTSSKSLESs
S557 AKASRTSSKSLESsA
- gap
- gap
- gap
- gap
- gap
S563-p SSKSLESsAGTVAAS
  mouse

 
S10-p RWFHRDLsGPDAETL
K19 PDAETLLKGRGVPGS
S26 KGRGVPGSFLARPSR
S57-p THIRIQNsGDFYDLy
Y61 IQNsGDFYDLyGGEK
Y64-p sGDFYDLyGGEKFAT
Y98-p GTIIHLKyPLNCSDP
Y111 DPTSERWYHGHISGG
Y176 VMCEGGRYTVGGSET
T177 MCEGGRYTVGGSETF
S186 GGSETFDSLtDLVEH
T188-p SETFDSLtDLVEHFK
Y208-p EASGAFVyLRQPyyA
Y213-p FVyLRQPyyATRVNA
Y214-p VyLRQPyyATRVNAA
S250 GFWEEFESLQKQEVK
Y276 ENKSKNRYKNILPFD
K277 NKSKNRYKNILPFDH
K277 NKSKNRYKNILPFDH
S299 RDSNIPGSDYINANY
Y301 SNIPGSDYINANYVK
Y306 SDYINANYVKNQLLG
K308 YINANYVKNQLLGPD
Y364 GRNKCVPYWPEVGTQ
Y374 EVGTQRVYGLySVTN
Y377-p TQRVYGLySVTNSRE
S378 QRVYGLySVTNSREH
Y390 REHDTAEYkLRTLQI
K391-ub EHDTAEYkLRTLQIS
T394 TAEYkLRTLQISPLD
S398 kLRTLQISPLDNGDL
S496 QMVRAQRSGMVQTEA
Y509 EAQYKFIYVAIAQFI
S528 KKLEIIQSQKGQEsE
S534-p QSQKGQEsEyGNITy
Y536-p QKGQEsEyGNITyPP
T540 EsEyGNITyPPAVRS
Y541-p sEyGNITyPPAVRSA
S553 RSAHAKASRTSsKHK
T555 AHAKASRTSsKHKEE
S556 HAKASRTSsKHKEEV
S557-p AKASRTSsKHKEEVy
Y564-p sKHKEEVyENVHsKS
S569-p EVyENVHsKSKKEEK
S582 EKVKKQRSADKEKNK
N588 RSADKEKNKGsLKRK
S591-p DKEKNKGsLKRK___
- gap
8849 : Phospho-SHP-1 (Tyr564) (D11G5) Rabbit mAb
  rat

 
S12-p GWFHRDLsGPDAETL
K21 PDAETLLKGRGVPGS
S28 KGRGVPGSFLARPSR
S59 THIRIQNSGDFYDLY
Y63 IQNSGDFYDLYGGEK
Y66 SGDFYDLYGGEKFAT
Y100 GTIIHLKYPLNCSDP
Y113 DPTSERWYHGHMSGG
Y178 VMCEGGRYTVGGSET
T179 MCEGGRYTVGGSETF
S188 GGSETFDSLTDLVEH
T190 SETFDSLTDLVEHFK
Y210 EASGAFVYLRQPYYA
Y215 FVYLRQPYYATRVNA
Y216 VYLRQPYYATRVNAA
S252 GFWEEFESLQKQEAK
Y278 ENKSKNRYKNILPFD
K279 NKSKNRYKNILPFDH
K279 NKSKNRYKNILPFDH
S301 RDSNIPGSDYINANY
Y303 SNIPGSDYINANYVK
Y308 SDYINANYVKNQLLG
K310 YINANYVKNQLLGPD
Y366 GRNKCVPYWPEVGTQ
Y376 EVGTQRVYGLYSVTN
Y379 TQRVYGLYSVTNCKE
S380 QRVYGLYSVTNCKEH
Y392 KEHDTAEYKLRTLQI
K393 EHDTAEYKLRTLQIS
T396 TAEYKLRTLQISPLD
S400 KLRTLQISPLDNGDL
S498 QMVRAQRSGMVQTEA
Y511 EAQYKFIYVAIAQFI
S530 KKLEIIQSQRGQESE
S536 QSQRGQESEyGNITy
Y538-p QRGQESEyGNITyPP
T542 ESEyGNITyPPALRS
Y543-p SEyGNITyPPALRSA
S555 RSAHAKASRTSSKHK
T557 AHAKASRTSSKHKEE
S558 HAKASRTSSKHKEEV
S559 AKASRTSSKHKEEVY
Y566 SKHKEEVYENVHSKN
S571 EVYENVHSKNKKEEK
S584 EKVKKQRSADKEKNK
N590 RSADKEKNKGSLKRN
S593 DKEKNKGSLKRNISL
- gap
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