an intracellular tyrosine kinase of the Tec family expressed in T-cells. The protein contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Tec family
Chromosomal Location of Human Ortholog: 5q31-q32
Cellular Component: extrinsic to internal side of plasma membrane; intercellular junction; cytosol
Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: adaptive immune response; T cell activation; cytokine production; signal transduction; T cell receptor signaling pathway; regulation of cell proliferation; interleukin-4 production; B cell receptor signaling pathway; phospholipase C activation; interferon-gamma production; innate immune response; cellular defense response; NK T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.