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ITK (human)

Overview ITK an intracellular tyrosine kinase of the Tec family expressed in T-cells. The protein contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; Protein kinase, TK; TK group; Tec family Cellular Component: cytosol Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; phospholipid binding; ATP binding Biological Process: adaptive immune response; interleukin-4 production; T cell activation; phospholipase C activation; interferon-gamma production; cytokine production; cellular defense response; NK T cell differentiation; signal transduction; T cell receptor signaling pathway Reference #:  Q08881 (UniProtKB) Alt. Names/Synonyms: EMT; homolog of mouse T-cell itk/tsk; IL2-inducible T-cell kinase; ITK; Kinase EMT; LYK; MGC126257; MGC126258; PSCTK2; T-cell-specific kinase; Tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk Gene Symbols: ITK Molecular weight: 71,831 Da Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ITK 1SM2 - A/B=357-620 (human) 1SNU - A/B=357-620 (human) 1SNX - A/B=357-620 (human) 2E6I - A=113-169 (human) 2LMJ - A=171-231 (human) 2YUQ - A=162-239 (human) 3MIY - A/B=357-620 (human) 3MJ1 - A=357-620 (human) 3MJ2 - A=357-620 (human) 3QGW - A/B=357-620 (human) 3QGY - A/B=357-620 (human) 3T9T - A=354-620 (human) 3V5J - A/B=357-620 (human) 3V5L - A/D/C/B=357-620 (human) 3V8T - A/B=357-620 (human) 3V8W - A/B=357-620 (human) 4HCT - A=354-620 (human) 4HCU - A=354-620 (human) 4HCV - A=354-620 (human) 1AWJ - A=160-236 (mouse) 1LUI - A=238-344 (mouse) 1LUK - A=238-344 (mouse) 1LUM - A=238-344 (mouse) 1LUN - A=238-344 (mouse) 2ETZ - A=238-344 (mouse) 2EU0 - A=238-344 (mouse) 2K79 - A=177-237 B=238-344 (mouse) 2K7A - A=177-237 B=238-344 (mouse) 2RN8 - A=177-238 (mouse) 2RNA - A=177-238 (mouse) 3S9K - A=236-344 (mouse)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: Y512‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S22-p	SQQKRRTsPSNFKVR
0	3		Y40-p	LTKASLAyFEDRHGK
0	1		T50-p	DRHGKKRtLKGSIEL
0	10		Y90-p	VHDNYLLyVFAPDRE
0	1		S115-p	EETRNNNsLVPKyHP
0	2		Y120-p	NNsLVPKyHPNFWMD
0	1		K138-u	RCCSQLEkLAtGCAQ
0	1		T141-p	SQLEkLAtGCAQyDP
0	182		Y146-p	LAtGCAQyDPTKNAS
0	1		T160-p	SKKPLPPtPEDNRRP
2	79		Y180-p	ETVVIALyDyQtNDP
0	26		Y182-p	VVIALyDyQtNDPQE
0	1		T184-p	IALyDyQtNDPQELA
0	122		Y198-p	ALRRNEEyCLLDsSE
0	1		S203-p	EEyCLLDsSEIHWWR
0	31		Y220-p	DRNGHEGyVPsSyLV
0	7		S223-p	GHEGyVPsSyLVEKS
0	2		Y225-p	EGyVPsSyLVEKSPN
0	2		T236-p	KSPNNLEtyEWYNKS
0	33		Y237-p	SPNNLEtyEWYNKSI
0	49		Y273-p	DSRTAGTytVsVFTK
0	1		T274-p	SRTAGTytVsVFTKA
0	1		S276-p	TAGTytVsVFTKAVV
0	1		K296-a	CIKHYHIkETNDNPK
0	16		Y336-p	GLVTRLRyPVCFGRQ
0	1		Y353-p	PVTAGLRyGKWVIDP
0	1		K497-u	VGENQVIkVSDFGMT
2	269		Y512-p	RFVLDDQytsstGtK
0	5		T513-p	FVLDDQytsstGtKF
0	17		S514-p	VLDDQytsstGtKFP
0	6		S515-p	LDDQytsstGtKFPV
0	1		T516-p	DDQytsstGtKFPVK
0	1		T518-p	QytsstGtKFPVKWA
0	2		S565-p	PYENRSNsEVVEDIS
0	1		T585-p	YKPRLAStHVyQIMN
0	11		Y588-p	RLAStHVyQIMNHCW

	mouse
S22	SQQKRRTSPSNFKVR
Y40	LTKASLAYFEDRHGK
T50	DRHGKKRTLKGSIEL
Y96	VHDNYLLYVFAPDCE
S121	EETRNNNSLVSKYHP
Y126	NNSLVSKYHPNFWMD
K144	RCCSQLEKPAVGCAP
V147	SQLEKPAVGCAPYDP
Y152	PAVGCAPYDPSKNAS
T166	SKKPLPPTPEDNRRS
Y186-p	ETLVIALyDYQTNDP
Y188	LVIALyDYQTNDPQE
T190	IALyDYQTNDPQELA
Y204	ALRCDEEYYLLDSSE
S209	EEYYLLDSSEIHWWR
Y226	DKNGHEGYAPSSYLV
S229	GHEGYAPSSYLVEKS
Y231	EGYAPSSYLVEKSPN
T242	KSPNNLETYEWYNKS
Y243	SPNNLETYEWYNKSI
Y279	DSRTPGTYTVSVFTK
T280	SRTPGTYTVSVFTKA
S282	TPGTYTVSVFTKAII
K301	CIKHYHIKETNDSPK
Y341	GLVTRLRYPVCSWRQ
Y358	PVTAGLRYGKWVIQP
K502	VGENQVIKVSDFGMT
Y517-p	RFVLDDQyTSSTGTK
T518	FVLDDQyTSSTGTKF
S519	VLDDQyTSSTGTKFP
S520	LDDQyTSSTGTKFPV
T521	DDQyTSSTGTKFPVK
T523	QyTSSTGTKFPVKWA
S570	PYENRSNSEVVEDIS
C590	YKPRLASCHVYQIMN
Y593	RLASCHVYQIMNHCW

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