an intracellular tyrosine kinase of the Tec family expressed in T-cells. The protein contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 220.127.116.11; TK group; Tec family
Chromosomal Location of Human Ortholog: 5q31-q32
Cellular Component: cytosol
Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: interleukin-4 production; adaptive immune response; peptidyl-tyrosine phosphorylation; T cell activation; phospholipase C activation; interferon-gamma production; cellular defense response; cytokine production; innate immune response; NK T cell differentiation; signal transduction; T cell receptor signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.