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Protein Page:
ITK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITK an intracellular tyrosine kinase of the Tec family expressed in T-cells. The protein contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Tec family
Cellular Component: cytosol
Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: adaptive immune response; interleukin-4 production; peptidyl-tyrosine phosphorylation; T cell activation; phospholipase C activation; interferon-gamma production; cytokine production; innate immune response; cellular defense response; NK T cell differentiation; signal transduction; T cell receptor signaling pathway
Reference #:  Q08881 (UniProtKB)
Alt. Names/Synonyms: EMT; homolog of mouse T-cell itk/tsk; IL2-inducible T-cell kinase; ITK; Kinase EMT; LYK; MGC126257; MGC126258; PSCTK2; T-cell-specific kinase; Tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk
Gene Symbols: ITK
Molecular weight: 71,831 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITK

Protein Structure Not Found.


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Sites Implicated In
activity, induced: Y512‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S22-p SQQKRRTsPSNFKVR
0 3 Y40-p LTKASLAyFEDRHGK
0 1 T50-p DRHGKKRtLKGSIEL
0 12 Y90-p VHDNYLLyVFAPDRE
0 1 S115-p EETRNNNsLVPKyHP
0 3 Y120-p NNsLVPKyHPNFWMD
0 1 K138-ub RCCSQLEkLAtGCAQ
0 1 T141-p SQLEkLAtGCAQyDP
0 167 Y146-p LAtGCAQyDPTKNAS
0 1 T160-p SKKPLPPtPEDNRRP
2 78 Y180-p ETVVIALyDyQtNDP
0 26 Y182-p VVIALyDyQtNDPQE
0 1 T184-p IALyDyQtNDPQELA
0 127 Y198-p ALRRNEEyCLLDsSE
0 2 S203-p EEyCLLDsSEIHWWR
0 36 Y220-p DRNGHEGyVPssyLV
0 8 S223-p GHEGyVPssyLVEKS
0 1 S224-p HEGyVPssyLVEKSP
0 2 Y225-p EGyVPssyLVEKSPN
0 2 T236-p KSPNNLEtyEWYNKS
0 36 Y237-p SPNNLEtyEWYNKSI
0 51 Y273-p DSRTAGTytVsVFTK
0 1 T274-p SRTAGTytVsVFTKA
0 3 S276-p TAGTytVsVFTKAVV
0 1 K296-ac CIKHYHIkETNDNPK
0 16 Y336-p GLVTRLRyPVCFGRQ
0 1 Y353-p PVTAGLRyGKWVIDP
0 1 K497-ub VGENQVIkVsDFGMt
0 1 S499-p ENQVIkVsDFGMtRF
0 1 T504-p kVsDFGMtRFVLDDQ
2 254 Y512-p RFVLDDQytsstGtK
0 8 T513-p FVLDDQytsstGtKF
0 17 S514-p VLDDQytsstGtKFP
0 7 S515-p LDDQytsstGtKFPV
0 1 T516-p DDQytsstGtKFPVK
0 1 T518-p QytsstGtKFPVKWA
0 2 S565-p PYENRSNsEVVEDIS
0 1 T585-p YKPRLAStHVyQIMN
0 14 Y588-p RLAStHVyQIMNHCW
  mouse

 
S22 SQQKRRTSPSNFKVR
Y40 LTKASLAYFEDRHGK
T50 DRHGKKRTLKGSIEL
Y96 VHDNYLLYVFAPDCE
S121 EETRNNNSLVSKYHP
Y126 NNSLVSKYHPNFWMD
K144 RCCSQLEKPAVGCAP
V147 SQLEKPAVGCAPYDP
Y152 PAVGCAPYDPSKNAS
T166 SKKPLPPTPEDNRRS
Y186-p ETLVIALyDYQTNDP
Y188 LVIALyDYQTNDPQE
T190 IALyDYQTNDPQELA
Y204 ALRCDEEYYLLDSSE
S209 EEYYLLDSSEIHWWR
Y226 DKNGHEGYAPSSYLV
S229 GHEGYAPSSYLVEKS
S230 HEGYAPSSYLVEKSP
Y231 EGYAPSSYLVEKSPN
T242 KSPNNLETYEWYNKS
Y243 SPNNLETYEWYNKSI
Y279 DSRTPGTYTVSVFTK
T280 SRTPGTYTVSVFTKA
S282 TPGTYTVSVFTKAII
K301 CIKHYHIKETNDSPK
Y341 GLVTRLRYPVCSWRQ
Y358 PVTAGLRYGKWVIQP
K502 VGENQVIKVSDFGMT
S504 ENQVIKVSDFGMTRF
T509 KVSDFGMTRFVLDDQ
Y517-p RFVLDDQyTSSTGTK
T518 FVLDDQyTSSTGTKF
S519 VLDDQyTSSTGTKFP
S520 LDDQyTSSTGTKFPV
T521 DDQyTSSTGTKFPVK
T523 QyTSSTGTKFPVKWA
S570 PYENRSNSEVVEDIS
C590 YKPRLASCHVYQIMN
Y593 RLASCHVYQIMNHCW
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