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Protein Page:
Ago2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Ago2 the endonuclease in RNA-induced silencing complexes (RISC) that cleaves siRNA/mRNA heteroduplexes bound to RISC. Ago2, along with Dicer and TRBP, are major components of RISC. Interacts with Dicer1 through its Piwi domain. Required for proper fibroblast growth factor signaling during gastrulation. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi). Note: This description may include information from UniProtKB.
Protein type: RNA processing; EC 3.1.26.n2
Cellular Component: polysome; mRNA cap complex; cytoplasm; cytosol; ribonucleoprotein complex; nucleus
Molecular Function: mRNA binding; endoribonuclease activity; protein binding; siRNA binding; miRNA binding; translation initiation factor activity; metal ion binding; RNA 7-methylguanosine cap binding
Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; negative regulation of translational initiation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; translation; transcription, DNA-dependent; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; post-embryonic development; regulation of transcription, DNA-dependent; pre-microRNA processing; translational initiation; innate immune response; RNA-mediated gene silencing; gene expression
Reference #:  Q9UKV8 (UniProtKB)
Alt. Names/Synonyms: AGO2; argonaute 2; Argonaute2; eIF-2C 2; eIF2C 2; EIF2C2; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 2; hAgo2; MGC3183; PAZ Piwi domain protein; PPD; Protein argonaute-2; Protein slicer; Q10
Gene Symbols: EIF2C2
Molecular weight: 97,208 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ago2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: Y393‑p
translation, inhibited: S387‑p
activity, inhibited: Y529‑p
enzymatic activity, inhibited: S387‑p
intracellular localization: S387‑p, Y529‑p
molecular association, regulation: Y393‑p, Y529‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S153-p ALSGRLPsVPFETIQ
0 2 K248-u KSIEEQQkPLTDsQR
1 1 S253-p QQkPLTDsQRVKFTK
1 1 T303-p LQQESGQtVECtVAQ
1 1 T307-p SGQtVECtVAQYFKD
0 3 Y338-p GQEQKHTyLPLEVCN
0 3 S385-p EISKLMRsAsFNTDP
3 24 S387-p SKLMRsAsFNTDPyV
2 1 Y393-p AsFNTDPyVREFGIM
0 2 K425-u ILYGGRNkAIATPVQ
1 1 Y529-p LPGKTPVyAEVKRVG
0 3 K720-u TRLFCTDkNERVGkS
0 2 K726-u DkNERVGkSGNIPAG
0 1 Y749-p HPTEFDFyLCsHAGI
0 1 S752-p EFDFyLCsHAGIQGt
0 1 T759-p sHAGIQGtsRPSHYH
0 1 S760-p HAGIQGtsRPSHYHV
1 1 S798-p VRCTRSVsIPAPAYY
0 1 S824-p LVDKEHDsAEGsHTs
0 1 S828-p EHDsAEGsHTsGQSN
0 1 S831-p sAEGsHTsGQSNGRD
0 1 K844-u RDHQALAkAVQVHQD
  mouse

 
S154-p ALSGRLPsVPFETIQ
K249-u KSIEEQQkPLTDSQR
S254 QQkPLTDSQRVKFTK
T304 LQQESGQTVECTVAQ
T308 SGQTVECTVAQYFKD
Y339 GQEQKHTYLPLEVCN
S386-p EISKLMRsAsFNTDP
S388-p SKLMRsAsFNTDPYV
Y394 AsFNTDPYVREFGIM
K426-u ILYGGRNkAIATPVQ
Y530 LPGKTPVYAEVKRVG
K721-u TRLFCTDkNERVGkS
K727-u DkNERVGkSGNIPAG
Y750 HPTEFDFYLCSHAGI
S753 EFDFYLCSHAGIQGT
T760 SHAGIQGTSRPSHYH
S761 HAGIQGTSRPSHYHV
S799 VRCTRSVSIPAPAYY
S825-p LVDKEHDsAEGSHTs
S829 EHDsAEGSHTsGQSN
S832-p sAEGSHTsGQSNGRD
K845 RDHQALAKAVQVHQD
  rat

 
S154 ALSGRLPSVPFETIQ
K249 KSIEEQQKPLTDSQR
S254 QQKPLTDSQRVKFTK
T304 LQQESGQTVECTVAQ
T308 SGQTVECTVAQYFKD
Y339 GQEQKHTYLPLEVCN
S386 EISKLMRSASFNTDP
S388 SKLMRSASFNTDPYV
Y394 ASFNTDPYVREFGIM
K426 ILYGGRNKAIATPVQ
Y530 LPGKTPVYAEVKRVG
K721 TRLFCTDKNERVGKS
K727 DKNERVGKSGNIPAG
Y750 HPTEFDFYLCSHAGI
S753 EFDFYLCSHAGIQGT
T760 SHAGIQGTSRPSHYH
S761 HAGIQGTSRPSHYHV
S799 VRCTRSVSIPAPAYY
S825 LVDKEHDSAEGSHTS
S829 EHDSAEGSHTSGQSN
S832 SAEGSHTSGQSNGRD
K845 RDHQALAKAVQVHQD
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