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Protein Page:
AGO2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AGO2 the endonuclease in RNA-induced silencing complexes (RISC) that cleaves siRNA/mRNA heteroduplexes bound to RISC. Ago2, along with Dicer and TRBP, are major components of RISC. Interacts with Dicer1 through its Piwi domain. Required for proper fibroblast growth factor signaling during gastrulation. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi). Note: This description may include information from UniProtKB.
Protein type: EC 3.1.26.n2; RNA processing
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: polysome; mRNA cap complex; membrane; cytoplasm; cytosol; nucleus; ribonucleoprotein complex
Molecular Function: mRNA binding; endoribonuclease activity; protein binding; miRNA binding; siRNA binding; metal ion binding; translation initiation factor activity; RNA 7-methylguanosine cap binding
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of translational initiation; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; translation; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; post-embryonic development; regulation of transcription, DNA-dependent; pre-microRNA processing; translational initiation; innate immune response; gene expression; RNA-mediated gene silencing
Reference #:  Q9UKV8 (UniProtKB)
Alt. Names/Synonyms: AGO2; argonaute 2; Argonaute2; eIF-2C 2; eIF2C 2; EIF2C2; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 2; hAgo2; MGC3183; PAZ Piwi domain protein; PPD; Protein argonaute-2; Protein slicer; Q10
Gene Symbols: AGO2
Molecular weight: 97,208 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AGO2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: Y393‑p
translation, inhibited: S387‑p
activity, inhibited: Y529‑p
enzymatic activity, inhibited: S387‑p
intracellular localization: S387‑p, Y529‑p
molecular association, regulation: Y393‑p, Y529‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S153-p ALSGRLPsVPFETIQ
0 1 T158 LPsVPFETIQALDVV
0 1 S171 VVMRHLPSMRYTPVG
0 2 K248-ub KSIEEQQkPLTDsQR
1 1 S253-p QQkPLTDsQRVKFTK
0 1 R255 kPLTDsQRVKFTKEI
1 1 T303-p LQQESGQtVECtVAQ
1 1 T307-p SGQtVECtVAQYFKD
0 1 K317-ac QYFKDRHkLVLRYPH
0 3 Y338-p GQEQKHTyLPLEVCN
0 1 T357-p QRCIKKLtDNQTSTM
0 3 S385-p EISKLMRsAsFNtDP
3 26 S387-p SKLMRsAsFNtDPyV
0 1 T390-p MRsAsFNtDPyVREF
4 1 Y393-p AsFNtDPyVREFGIM
1 0 K402-sm REFGIMVkDEMTDVT
0 2 K425-ub ILYGGRNkAIATPVQ
0 1 T526-p VVILPGKtPVyAEVK
1 1 Y529-p LPGKtPVyAEVKRVG
0 3 K720-ub TRLFCTDkNERVGkS
0 2 K726-ub DkNERVGkSGNIPAG
0 1 Y749-p HPTEFDFyLCsHAGI
0 1 S752-p EFDFyLCsHAGIQGt
0 1 T759-p sHAGIQGtsRPSHYH
0 1 S760-p HAGIQGtsRPSHYHV
1 1 S798-p VRCTRSVsIPAPAYY
0 1 S824-p LVDKEHDsAEGsHTs
0 1 S828-p EHDsAEGsHTsGQSN
0 1 S831-p sAEGsHTsGQSNGRD
0 1 K844-ub RDHQALAkAVQVHQD
  mouse

 
S154-p ALSGRLPsVPFEtIQ
T159-p LPsVPFEtIQALDVV
S172-p VVMRHLPsMRYTPVG
K249-ub KSIEEQQkPLTDSQr
S254 QQkPLTDSQrVKFTK
R256-m2 kPLTDSQrVKFTKEI
T304 LQQESGQTVECTVAQ
T308 SGQTVECTVAQYFKD
K318 QYFKDRHKLVLRYPH
Y339 GQEQKHTYLPLEVCN
T358 QRCIKKLTDNQTSTM
S386-p EISKLMRsAsFNTDP
S388-p SKLMRsAsFNTDPYV
T391 MRsAsFNTDPYVREF
Y394 AsFNTDPYVREFGIM
K403 REFGIMVKDEMTDVT
K426-ub ILYGGRNkAIATPVQ
T527 VVILPGKTPVYAEVK
Y530 LPGKTPVYAEVKRVG
K721-ub TRLFCTDkNERVGkS
K727-ub DkNERVGkSGNIPAG
Y750 HPTEFDFYLCSHAGI
S753 EFDFYLCSHAGIQGT
T760 SHAGIQGTSRPSHYH
S761 HAGIQGTSRPSHYHV
S799 VRCTRSVSIPAPAYY
S825-p LVDKEHDsAEGSHTs
S829 EHDsAEGSHTsGQSN
S832-p sAEGSHTsGQSNGRD
K845 RDHQALAKAVQVHQD
  rat

 
S154 ALSGRLPSVPFETIQ
T159 LPSVPFETIQALDVV
S172 VVMRHLPSMRYTPVG
K249 KSIEEQQKPLTDSQR
S254 QQKPLTDSQRVKFTK
R256 KPLTDSQRVKFTKEI
T304 LQQESGQTVECTVAQ
T308 SGQTVECTVAQYFKD
K318 QYFKDRHKLVLRYPH
Y339 GQEQKHTYLPLEVCN
T358 QRCIKKLTDNQTSTM
S386 EISKLMRSAsFNTDP
S388-p SKLMRSAsFNTDPYV
T391 MRSAsFNTDPYVREF
Y394 AsFNTDPYVREFGIM
K403 REFGIMVKDEMTDVT
K426 ILYGGRNKAIATPVQ
T527 VVILPGKTPVYAEVK
Y530 LPGKTPVYAEVKRVG
K721 TRLFCTDKNERVGKS
K727 DKNERVGKSGNIPAG
Y750 HPTEFDFYLCSHAGI
S753 EFDFYLCSHAGIQGT
T760 SHAGIQGTSRPSHYH
S761 HAGIQGTSRPSHYHV
S799 VRCTRSVSIPAPAYY
S825 LVDKEHDSAEGSHTS
S829 EHDSAEGSHTSGQSN
S832 SAEGSHTSGQSNGRD
K845 RDHQALAKAVQVHQD
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