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Oct2
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein |
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Cellular Component: cytoplasm; nucleus
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Molecular Function: protein domain specific binding; sequence-specific DNA binding; transcription factor activity
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Biological Process: transcription from RNA polymerase II promoter; immunoglobulin secretion during immune response; mature B cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; humoral immune response
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Reference #:
P09086 (UniProtKB)
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| Alt. Names/Synonyms: homeobox protein; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Oct-2; OCT2; Octamer-binding protein 2; Octamer-binding transcription factor 2; OTF-2; OTF2; PO2F2; POU class 2 homeobox 2; POU domain, class 2, transcription factor 2; POU2F2 |
| Gene Symbols: POU2F2 |
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Molecular weight: 51,209 Da
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Basal Isoelectric point: 8.6
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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