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Protein Page:
ERC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ERC1 Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: Golgi membrane; presynaptic membrane; cytoplasm; IkappaB kinase complex
Molecular Function: protein binding; leucine zipper domain binding; Rab GTPase binding
Biological Process: protein transport; regulation of transcription, DNA-dependent; multicellular organismal development; I-kappaB phosphorylation; retrograde transport, endosome to Golgi; activation of NF-kappaB transcription factor
Reference #:  Q8IUD2 (UniProtKB)
Alt. Names/Synonyms: Cast2; ELKS; ELKS/Rab6-interacting/CAST family member 1; ERC-1; ERC1; FLJ31750; KIAA1081; MGC12974; RAB6 interacting protein 2; Rab6-interacting protein 2; RAB6IP2; RB6I2
Gene Symbols: ERC1
Molecular weight: 128,086 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ERC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S7 _MYGSARSVGKVEPs
0 5 S14-p SVGKVEPssQsPGRs
0 9 S15-p VGKVEPssQsPGRsP
0 31 S17-p KVEPssQsPGRsPRL
0 63 S21-p ssQsPGRsPRLPRsP
0 19 S27-p RsPRLPRsPRLGHRR
0 16 T35-p PRLGHRRtNstGGsS
0 81 S37-p LGHRRtNstGGsSGS
0 3 T38-p GHRRtNstGGsSGSS
0 7 S41-p RtNstGGsSGSSVGG
0 2 S42 tNstGGsSGSSVGGG
0 1 S45 tGGsSGSSVGGGSGK
0 1 T53 VGGGSGKTLsMENIQ
0 6 S55-p GGSGKTLsMENIQSL
0 1 Y73-p YATSGPMyLsDHENV
0 6 S75-p TSGPMyLsDHENVGS
0 1 S87 VGSETPKSTMTLGRs
0 1 T88 GSETPKSTMTLGRsG
0 1 T90 ETPKSTMTLGRsGGR
0 2 S94-p STMTLGRsGGRLPYG
0 1 S109 VRMTAMGSSPNIASS
0 1 S116 SSPNIASSGVASDTI
0 1 S134 EHHLPPVSMASTVPH
0 2 T138 PPVSMASTVPHSLRQ
0 1 T150 LRQARDNTIMDLQTQ
0 1 S181-p VKESKLSsSMNSIKT
0 1 K187 SsSMNSIKTFWsPEL
0 23 S191-p NSIKTFWsPELKKER
0 4 S252 LFQQDSSSRTGEPCV
0 1 K552-ub IQDMAEEkGTQAGEI
0 1 K590-ac LQEQLRDkEKQMSSL
0 1 K592 EQLRDkEKQMSSLKE
0 2 K652-ac EEIDNYKkDLkDLkE
0 1 K655-ac DNYKkDLkDLkEKVS
0 2 K658-ac KkDLkDLkEKVSLLQ
0 1 K679 EASLLDLKEHASSLA
0 1 K799-ac KVANLKHkEQVEKkK
0 1 K805-ac HkEQVEKkKSAQMLE
0 1 N820 EARRREDNLNDSSQQ
0 1 T868 AQEESARTNAEKQVE
0 1 K885 LMAMEKVKQELESMK
0 1 K894 ELESMKAKLSSTQQS
0 1 S948 NIALLELSSSKKKTQ
0 4 Y987-p MKLMADNyEDDHFKS
0 2 S1005 NQTNHKPSPDQIIQP
0 2 T1046-p PLILRGLtPPAsyNL
0 1 S1050-p RGLtPPAsyNLDDDQ
0 1 Y1051-p GLtPPAsyNLDDDQA
  ERC1 iso4  
S7 _MYGSARSVGKVEPS
S14 SVGKVEPSSQSPGRS
S15 VGKVEPSSQSPGRSP
S17 KVEPSSQSPGRSPRL
S21 SSQSPGRSPRLPRSP
S27 RSPRLPRSPRLGHRR
T35 PRLGHRRTNSTGGSS
S37 LGHRRTNSTGGSSGS
T38 GHRRTNSTGGSSGSS
S41 RTNSTGGSSGSSVGG
S42 TNSTGGSSGSSVGGG
S45 TGGSSGSSVGGGSGK
T53 VGGGSGKTLSMENIQ
S55 GGSGKTLSMENIQSL
Y73 YATSGPMYLSDHENV
S75 TSGPMYLSDHENVGS
S87 VGSETPKSTMTLGRS
T88 GSETPKSTMTLGRSG
T90 ETPKSTMTLGRSGGR
S94 STMTLGRSGGRLPYG
S109 VRMTAMGSSPNIASS
S116 SSPNIASSGVASDTI
S134 EHHLPPVSMASTVPH
T138 PPVSMASTVPHSLRQ
T150 LRQARDNTIMDLQTQ
S181 VKESKLSSSMNSIKT
K187 SSSMNSIKTFWSPEL
S191 NSIKTFWSPELKKER
S252 LFQQDSSSRTGEPCV
K524 IQDMAEEKGTQAGEI
K562 LQEQLRDKEKQMSSL
K564 EQLRDKEKQMSSLKE
K624 EEIDNYKKDLKDLKE
K627 DNYKKDLKDLKEKVS
K630 KKDLKDLKEKVSLLQ
K651 EASLLDLKEHASSLA
K775 KVANLKHKEQVEKKK
K781 HKEQVEKKKSAQMLE
N796 EARRREDNLNDSSQQ
- gap
K817 LMAMEKVKQELESMK
K826 ELESMKAKLSSTQQS
S880 NIALLELSSSKKKTQ
Y919 MKLMADNYEDDHFKS
S937 NQTNHKPSPDQDEEE
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S7-p _MYGSARsVGKVEPs
S14-p sVGKVEPssQsPGRs
S15-p VGKVEPssQsPGRsP
S17-p KVEPssQsPGRsPRL
S21-p ssQsPGRsPRLPRsP
S27-p RsPRLPRsPRLGHRR
T35-p PRLGHRRtNstGGss
S37-p LGHRRtNstGGssGN
T38-p GHRRtNstGGssGNs
S41-p RtNstGGssGNsVGG
S42-p tNstGGssGNsVGGG
S45-p tGGssGNsVGGGSGK
T53-p VGGGSGKtLsMENIQ
S55-p GGSGKtLsMENIQSL
Y73 YATSGPMYLsDHENV
S75-p TSGPMYLsDHENVGA
S87-p VGAETPKstMtLGRS
T88-p GAETPKstMtLGRSG
T90-p ETPKstMtLGRSGGR
S94 stMtLGRSGGRLPYG
S109-p VRMTAMGsSPNIASs
S116-p sSPNIASsGVASDTI
S134-p EHHLPPVsMAStVPH
T138-p PPVsMAStVPHSLRQ
T150-p LRQARDNtIMDLQTQ
S181 VKESKLSSSMNSIkT
K187-ac SSSMNSIkTFWsPEL
S191-p NSIkTFWsPELKKER
S252-p LFQQDSSsRTGEPCV
K552 IQDMAEEKGTQAGEI
K590 LQEQLRDKEkQMSSL
K592-ac EQLRDKEkQMSSLKE
K652 EEIDTYKKDLKDLRE
K655 DTYKKDLKDLREKVS
R658 KKDLKDLREKVSLLQ
K679-ub EASLLDIkEHASSLA
K803 KVANLKHKEQVEKKK
K809 HKEQVEKKKSAQMLE
S824-p EARRREDsLSDSSQQ
T872-p AQEESARtNAEKQVE
K889-ub LMAMEKVkQELESMK
K898-ub ELESMKAkLSSTQQS
S952-p NIALLELsSSKKKTQ
Y991 MKLMADNYEDDHFRS
S1009 NQTNHKPSPDQIIQP
T1050 PLILRGLTPPASYNA
S1054 RGLTPPASYNADGEQ
Y1055 GLTPPASYNADGEQA
  ERC1 iso2  
S7 _MYGSARSVGKVEPS
S14 SVGKVEPSSQSPGRS
S15 VGKVEPSSQSPGRSP
S17 KVEPSSQSPGRSPRL
S21 SSQSPGRSPRLPRSP
S27 RSPRLPRSPRLGHRR
T35 PRLGHRRTNSTGGSS
S37 LGHRRTNSTGGSSGN
T38 GHRRTNSTGGSSGNS
S41 RTNSTGGSSGNSVGG
S42 TNSTGGSSGNSVGGG
S45 TGGSSGNSVGGGSGK
T53 VGGGSGKTLSMENIQ
S55 GGSGKTLSMENIQSL
Y73 YATSGPMYLSDHENV
S75 TSGPMYLSDHENVGA
S87 VGAETPKSTMTLGRS
T88 GAETPKSTMTLGRSG
T90 ETPKSTMTLGRSGGR
S94 STMTLGRSGGRLPYG
S109 VRMTAMGSSPNIASS
S116 SSPNIASSGVASDTI
S134 EHHLPPVSMASTVPH
T138 PPVSMASTVPHSLRQ
T150 LRQARDNTIMDLQTQ
S181 VKESKLSSSMNSIKT
K187 SSSMNSIKTFWSPEL
S191 NSIKTFWSPELKKER
S252 LFQQDSSSRTGEPCV
K552 IQDMAEEKGTQAGEI
K590 LQEQLRDKEKQMSSL
K592 EQLRDKEKQMSSLKE
K652 EEIDTYKKDLKDLRE
K655 DTYKKDLKDLREKVS
R658 KKDLKDLREKVSLLQ
K679 EASLLDIKEHASSLA
K803 KVANLKHKEQVEKKK
K809 HKEQVEKKKSAQMLE
S824 EARRREDSLSDSSQQ
- gap
K845 LMAMEKVKQELESMK
K854 ELESMKAKLSSTQQS
S908 NIALLELSSSKKKTQ
Y947 MKLMADNYEDDHFRS
S965-p NQTNHKPsPDQDEEE
- gap
- gap
- gap
  rat

 
S7 _MYGSARSVGKVEPS
S14 SVGKVEPSSQsPGRs
S15 VGKVEPSSQsPGRsP
S17-p KVEPSSQsPGRsPRL
S21-p SSQsPGRsPRLPRSP
S27 RsPRLPRSPRLGHRR
T35 PRLGHRRTNSTGGSS
S37 LGHRRTNSTGGSSGN
T38 GHRRTNSTGGSSGNS
S41 RTNSTGGSSGNSVGG
S42 TNSTGGSSGNSVGGG
S45 TGGSSGNSVGGGSGK
T53 VGGGSGKTLSMENIQ
S55 GGSGKTLSMENIQSL
Y73 YATSGPMYLSDHENV
S75 TSGPMYLSDHENVGA
S87 VGAETPKSTMTLGRS
T88 GAETPKSTMTLGRSG
T90 ETPKSTMTLGRSGGR
S94 STMTLGRSGGRLPYG
S109 VRMTAMGSSPNIASS
S116 SSPNIASSGVASDTI
S134 EHHLPPVSMASTVPH
T138 PPVSMASTVPHSLRQ
T150 LRQARDNTIMDLQTQ
S181 VKESKLSSSMNSIKT
K187 SSSMNSIKTFWSPEL
S191 NSIKTFWSPELKKER
S252 LFQQDSSSRTGEPCV
K524 IQDMAEEKGTQAGEI
K562 LQEQLRDKEKQMSSL
K564 EQLRDKEKQMSSLKE
K624 EEIDTYKKDLKDLKE
K627 DTYKKDLKDLKEKVS
K630 KKDLKDLKEKVSLLQ
K651 EASLLDLKEHASSLA
K775 KVANLKHKEQVEKKK
K781 HKEQVEKKKSAQMLE
S796 EARRREDSLSDSSQQ
- gap
K817 LMAMEKVKQELESMK
K826 ELESMKAKLSSTQQS
S880 NIALLELSSSKKKTQ
Y919 MKLMADNYEDDHFRS
S937 NQTNHKPSPDQDEEE
- gap
- gap
- gap
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