Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ATG16 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG16 Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, peripheral; Autophagy; Adaptor/scaffold
Cellular Component: pre-autophagosomal structure membrane; autophagic vacuole; axoneme
Molecular Function: identical protein binding; protein binding
Biological Process: protein transport; protein homooligomerization; autophagic vacuole formation
Reference #:  Q676U5 (UniProtKB)
Alt. Names/Synonyms: A16L1; APG16 autophagy 16-like; APG16-like 1; APG16L; APG16L beta; ATG16; ATG16 autophagy related 16-like 1 (S. cerevisiae); ATG16 autophagy related 16-like protein 1; ATG16L; ATG16L1; Autophagy-related protein 16-1; FLJ00045; FLJ10035; FLJ10828; FLJ22677; IBD10; WD repeat domain 30; WDR30
Gene Symbols: ATG16L1
Molecular weight: 68,265 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG16

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S18-p PRWKRHIsEQLRRRD
0 1 S70-p VPNRHEIsPGHDGTW
0 2 K211 RLNAENEKDSRRRQA
0 2 S255-p SDHTEETsPVRAISR
0 4 T265-p RAISRAAtKRLsQPA
0 20 S269-p RAAtKRLsQPAGGLL
0 8 S278-p PAGGLLDsITNIFGR
0 13 S287-p TNIFGRRsVssFPVP
0 2 S289-p IFGRRsVssFPVPQD
0 3 S290-p FGRRsVssFPVPQDN
0 1 S304-p NVDTHPGsGKEVRVP
0 1 S331-p EVNAVQFsPGSRLLA
0 1 S361 EKCEFKGSLSGSNAG
0 1 S371 GSNAGITSIEFDSAG
0 2 K513-ub CSRDDLLkVIDLRTN
  ATG16 iso2  
S18 PRWKRHISEQLRRRD
S70 VPNRHEISPGHDGTW
K211 RLNAENEKDSRRRQA
S255 SDHTEETSPVRAISR
T265-p RAISRAAtRRSVSSF
- gap
- gap
S268 SRAAtRRSVSSFPVP
S270 AAtRRSVSSFPVPQD
S271 AtRRSVSSFPVPQDN
S285 NVDTHPGSGKEVRVP
S312 EVNAVQFSPGSRLLA
S342 EKCEFKGSLSGSNAG
S352 GSNAGITSIEFDSAG
K494 CSRDDLLKVIDLRTN
  mouse

► Hide Isoforms
 
A18 PRWKRHIAEELRRRD
S70 MPNRHEISPGHDGAW
K211-ac RLNAENEkDSRRRQA
S255-p SDHTEETsPVRAVSR
T265 RAVSRAATKRLsQPA
S269-p RAATKRLsQPAGGLL
S278 PAGGLLDSITNIFGR
S287-p TNIFGRRsVssIPVP
S289-p IFGRRsVssIPVPQD
S290-p FGRRsVssIPVPQDI
S304 IMDTHPASGKDVRVP
S331 EVNAVQFSPGSRLLA
S361-p DKCEFKGsLSGSNAG
S371-p GSNAGITsIEFDSAG
K513-ub CSRDDLLkVIDLRTN
  ATG16 iso3  
A18 PRWKRHIAEELRRRD
S70 MPNRHEISPGHDGAW
K211 RLNAENEKDSRRRQA
S255 SDHTEETSPVRAVSR
T265 RAVSRAATKRLsQPA
S269-p RAATKRLsQPAGGLL
S278 PAGGLLDSITNIFGL
S303 SDAARRRSVSSIPVP
S305 AARRRSVSSIPVPQD
S306 ARRRSVSSIPVPQDI
S320 IMDTHPASGKDVRVP
S347 EVNAVQFSPGSRLLA
S377 DKCEFKGSLSGSNAG
S387 GSNAGITSIEFDSAG
K529 CSRDDLLKVIDLRTN
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.