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Protein Page:
NFM (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFM a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: axon; neurofilament; neuromuscular junction
Molecular Function: protein binding; structural constituent of cytoskeleton; microtubule binding
Biological Process: neurofilament bundle assembly; regulation of axon diameter; axon cargo transport; microtubule cytoskeleton organization and biogenesis
Reference #:  P07197 (UniProtKB)
Alt. Names/Synonyms: 160 kDa neurofilament protein; NEF3; NEFM; Neurofilament 3; Neurofilament medium polypeptide; Neurofilament triplet M protein; neurofilament, medium polypeptide; neurofilament, medium polypeptide 150kDa; neurofilament-3 (150 kD medium); NF-M; NFM
Gene Symbols: NEFM
Molecular weight: 102,472 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFM

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S2 ______MSYTLDSLG
1 0 T18 PSAYRRVTETRSsFS
0 1 T20 AYRRVTETRSsFSRV
1 0 S23-p RVTETRSsFSRVsGs
0 1 R26 ETRSsFSRVsGsPSs
0 2 S28-p RSsFSRVsGsPSsGF
0 1 S28 RSsFSRVSGsPSsGF
0 7 S30-p sFSRVsGsPSsGFRs
0 1 S33-p RVsGsPSsGFRsQSW
1 1 S33 RVsGsPSSGFRsQSW
0 1 S37 sPSsGFRSQSWSrGs
0 1 S37-p sPSsGFRsQSWSrGs
0 7 R42-m1 FRsQSWSrGsPSTVS
0 1 R42 FRsQSWSRGsPSTVS
0 3 S44-p sQSWSrGsPSTVSSS
1 1 S46 SWSrGsPSTVSSSYK
0 2 S46 SWSrGsPSTVSSSYK
1 1 T47 WSrGsPSTVSSSYKR
0 1 T47 WSrGsPSTVSSSYKR
0 2 S49 rGsPSTVSSSYKRSM
0 1 S50 GsPSTVSSSYKRSML
0 1 S51 sPSTVSSSYKRSMLA
0 7 K53 STVSSSYKRSMLAPR
0 1 S73-p AMLSSAEsSLDFSQS
0 1 S80 sSLDFSQSSSLLNGG
0 1 S82 LDFSQSSSLLNGGSG
0 1 S88 SSLLNGGSGPGGDYK
0 1 Y94 GSGPGGDYKLSRSNE
0 3 S99 GDYKLSRSNEKEQLQ
0 4 K102 KLSRSNEKEQLQGLN
0 1 K118-ub RFAGYIEkVHYLEQQ
0 1 K127 HYLEQQNKEIEAEIQ
0 4 K139 EIQALRQKQASHAQL
0 2 S142 ALRQKQASHAQLGDA
0 3 K168 LEMVNHEKAQVQLDS
0 1 A213 LRKDIEEASLVKVEL
0 1 S214 RKDIEEASLVKVELD
0 1 K223 VKVELDKKVQsLQDE
0 4 S226-p ELDKKVQsLQDEVAF
0 2 K259-ub SHITVERkDYLkTDI
0 8 K263-ub VERkDYLkTDISTAL
0 6 K271-ub TDISTALkEIRSQLE
0 1 K293 HQAEEWFKCRYAKLT
0 1 K298 WFKCRYAKLTEAAEQ
0 7 K307 TEAAEQNKEAIRSAK
0 1 K314 KEAIRSAKEEIAEYR
0 79 Y320 AKEEIAEYRRQLQSK
0 1 K327 YRRQLQSKSIELESV
0 5 S328 RRQLQSKSIELESVR
0 1 K338 LESVRGTKESLERQL
0 1 S340 SVRGTKESLERQLSD
0 2 S346 ESLERQLSDIEERHN
0 4 Y359 HNHDLSSYQDTIQQL
0 16 Y384-p MARHLREyQDLLNVK
0 4 Y401-p LDIEIAAyRKLLEGE
0 8 K403 IEIAAyRKLLEGEET
0 2 A416 ETRFSTFAGSITGPL
0 1 A416 ETRFSTFAGSITGPL
0 1 S418 RFSTFAGSITGPLYT
0 18 Y424 GSITGPLYTHRPPIT
0 1 T425 SITGPLYTHRPPITI
0 3 P429 PLYTHRPPITISSKI
0 1 P429 PLYTHRPPITISSKI
1 3 T431 YTHRPPITISSKIQK
0 2 K435 PPITISSKIQKPKVE
0 3 K438 TISSKIQKPKVEAPk
0 1 K445-ub KPKVEAPkLKVQHkF
0 1 K451-ub PkLKVQHkFVEEIIE
0 1 K461 EEIIEETKVEDEKsE
1 2 S467-p TKVEDEKsEMEEALT
1 0 T474 sEMEEALTAITEELA
0 1 S483 ITEELAVSMKEEKKE
0 1 K485 EELAVSMKEEKKEAA
3 13 S511-p EEVAAKKsPVKATAP
4 8 A515 AKKsPVKATAPEVKE
3 4 S545-p EEDEGAKsDQAEEGG
0 4 S553-p DQAEEGGsEKEGssE
0 6 S558-p GGsEKEGssEKEEGE
0 7 S559-p GsEKEGssEKEEGEQ
0 4 T571-p GEQEEGEtEAEAEGE
0 1 K598 KSEEVATKEELVADA
4 30 S615-p EKPEKAKsPVPKsPV
3 42 S620-p AKsPVPKsPVEEKGK
0 1 - gap
0 1 - gap
0 9 S628-p PVEEKGKsPVPKsPV
0 11 S633-p GKsPVPKsPVEEKGK
0 1 - gap
0 9 S641-p PVEEKGKsPVPKsPV
0 11 S646-p GKsPVPKsPVEEKGk
0 1 K653-ac sPVEEKGksPVPKsP
0 7 S654-p PVEEKGksPVPKsPV
0 11 S659-p GksPVPKsPVEEKGK
0 1 P660 ksPVPKsPVEEKGKs
0 10 S667-p PVEEKGKsPVsKsPV
0 4 S670-p EKGKsPVsKsPVEEK
0 6 S672-p GKsPVsKsPVEEKAK
0 1 E675 PVsKsPVEEKAKsPV
0 7 S680-p PVEEKAKsPVPKsPV
0 13 S685-p AKsPVPKsPVEEAKS
0 1 K693-ac PVEEAKSkAEVGkGE
0 1 K698-ac KSkAEVGkGEQKEEE
0 2 - gap
1 4 A712 EEKEVKEAPKEEKVE
4 12 S736-p PEKKKAEsPVKEEAV
0 1 E741 AEsPVKEEAVAEVVt
0 1 A742 EsPVKEEAVAEVVtI
0 2 T748-p EAVAEVVtItKSVKV
0 2 T750-p VAEVVtItKSVKVHL
0 3 K751 AEVVtItKSVKVHLE
0 1 K754 VtItKSVKVHLEKET
0 2 H756 ItKSVKVHLEKETKE
0 5 K759 SVKVHLEKETKEEGK
0 7 K762 VHLEKETKEEGKPLQ
0 9 K766 KETKEEGKPLQQEKE
0 11 S783-p KAGGEGGsEEEGsDK
0 7 S788-p GGsEEEGsDKGAKGS
0 6 G791 EEEGsDKGAKGSRKE
0 1 S795 sDKGAKGSRKEDIAV
0 1 T831 EEEKGVVTNGLDLsP
1 13 S837-p VTNGLDLsPADEKKG
0 2 K847 DEKKGGDKSEEKVVV
0 3 K856 EEKVVVTKTVEKITS
0 2 T857 EKVVVTKTVEKITSE
0 11 K860 VVTKTVEKITSEGGD
0 1 T870 SEGGDGATkyITkSV
0 3 K871-ub EGGDGATkyITkSVT
0 1 Y872-p GGDGATkyITkSVTV
0 3 K875-ub GATkyITkSVTVTQK
0 5 K910 VTSHAIVKEVTQSD_
0 1 T913 HAIVKEVTQSD____
  mouse

 
S2 ______MSYTLDSLG
T18 PSAYRRVTEtRSsFS
T20-p AYRRVTEtRSsFSrV
S23-p RVTEtRSsFSrVsGs
R26-m2 EtRSsFSrVsGsPSs
S28-p RSsFSrVsGsPSsGF
S28-gl RSsFSrVsGsPSsGF
S30-p sFSrVsGsPSsGFRs
S33 rVsGsPSSGFRsQSW
S33-gl rVsGsPSsGFRsQSW
S37-gl sPSsGFRsQSWSrGs
S37 sPSsGFRSQSWSrGs
R42-m1 FRsQSWSrGsPstVs
R42-m2 FRsQSWSrGsPstVs
S44-p sQSWSrGsPstVsss
S46-p SWSrGsPstVsssYk
S46-gl SWSrGsPstVsssYk
T47-gl WSrGsPstVsssYkR
T47-p WSrGsPstVsssYkR
S49-gl rGsPstVsssYkRSA
S50-gl GsPstVsssYkRSAL
S51-gl sPstVsssYkRSALA
K53-ub stVsssYkRSALAPR
S73 AMLSSAESSLDFSQS
S80 SSLDFSQSSSLLNGG
S82 LDFSQSSSLLNGGSG
S88 SSLLNGGSGGDYKLS
Y92 NGGSGGDYKLSRsNE
S97-p GDYKLSRsNEkEQLQ
K100-ub KLSRsNEkEQLQGLN
K116 RFAGYIEKVHYLEQQ
K125-ub HYLEQQNkEIEAEIQ
K137-ub EIQALRQkQAsHAQL
S140-p ALRQkQAsHAQLGDA
K166-ub LEMVNHEkAQVQLDS
S211-p LRKDIEEssMVKVEL
S212-p RKDIEEssMVKVELD
K221-ub VKVELDKkVQsLQDE
S224-p ELDKkVQsLQDEVAF
K257-ub SHITVERkDYLkTDI
K261-ub VERkDYLkTDISTAL
K269-ub TDISTALkEIRSQLE
K291-ub HQAEEWFkCRYAkLT
K296-ub WFkCRYAkLTEAAEQ
K305-ub TEAAEQNkEAIRSAk
K312-ub kEAIRSAkEEIAEyR
Y318-p AkEEIAEyRRQLQSk
K325-ub yRRQLQSksIELESV
S326-p RRQLQSksIELESVR
K336-ac LESVRGTkEsLERQL
S338-p SVRGTkEsLERQLsD
S344-p EsLERQLsDIEERHN
Y357 HNHDLSSYQDTIQQL
Y382 MARHLREYQDLLNVK
Y399 LDIEIAAYRkLLEGE
K401-ub IEIAAYRkLLEGEET
S414-p ETRFSTFsGsITGPL
S414-gl ETRFSTFsGsITGPL
S416-p RFSTFsGsITGPLYt
Y422 GsITGPLYtHRQPsV
T423-p sITGPLYtHRQPsVt
S428-p LYtHRQPsVtISSkI
S428-gl LYtHRQPsVtISSkI
T430-gl tHRQPsVtISSkIQk
K434-ub PsVtISSkIQkTKVE
K437-ub tISSkIQkTKVEAPK
K444 kTKVEAPKLKVQHKF
K450 PKLKVQHKFVEEIIE
K460-ub EEIIEETkVEDEKsE
S466-p TkVEDEKsEMEETLT
T473 sEMEETLTAIAEELA
S482-p IAEELAAsAkEEKEE
K484-ub EELAAsAkEEKEEAE
S502-p EEPEAEKsPVKsPEA
S506-p AEKsPVKsPEAKEEE
S537-p EEDEGVKsDQAEEGG
S545-p DQAEEGGsEKEGssE
S550-p GGsEKEGssEKDEGE
S551-p GsEKEGssEKDEGEQ
T565-p QEEEEGEtEAEGEGE
K592-ub KVEEVAVkEEIKVEK
S605-p EKPEKAKsPMPKsPV
S610-p AKsPMPKsPVEEVKP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T642-p EEEKKEVtKEsPKEE
S645-p KKEVtKEsPKEEKVE
S669-p ADKKKAEsPVKEkAV
K674-ub AEsPVKEkAVEEVIt
A675 EsPVKEkAVEEVItI
T681-p kAVEEVItIskSVkV
S683-p VEEVItIskSVkVsL
K684-ub EEVItIskSVkVsLE
K687-ub ItIskSVkVsLEkDT
S689-p IskSVkVsLEkDTkE
K692-ub SVkVsLEkDTkEEkP
K695-ub VsLEkDTkEEkPQPQ
K698-ub EkDTkEEkPQPQEKV
S715-p KAEEEGGsEEEGsDR
S720-p GGsEEEGsDRsPQEs
S723-p EEEGsDRsPQEsKKE
S727-p sDRsPQEsKKEDIAI
T763 EEEKGVVTNGLDVsP
S769-p VTNGLDVsPAEEKKG
S779-p EEKKGEDsSDDKVVV
K788-ub DDKVVVTkkVEkITS
K789-ub DKVVVTkkVEkITSE
K792-ub VVTkkVEkITSEGGD
T802-p SEGGDGAtkYITkSV
K803-ub EGGDGAtkYITkSVT
Y804 GGDGAtkYITkSVTV
K807-ub GAtkYITkSVTVTQK
K842-ub VTSHAIVkEVtQGD_
T845-p HAIVkEVtQGD____
  rat

 
S2-p ______MsYTLDSLG
T19-gl SAYRRVPtETRSSFS
T21 YRRVPtETRSSFSRV
S24 VPtETRSSFSRVSGs
R27 ETRSSFSRVSGsPSs
S29 RSSFSRVSGsPSsGF
S29 RSSFSRVSGsPSsGF
S31-p SFSRVSGsPSsGFRS
S34 RVSGsPSSGFRSQSW
S34-gl RVSGsPSsGFRSQSW
S38 sPSsGFRSQSWSRGS
S38 sPSsGFRSQSWSRGS
R43 FRSQSWSRGSPstVS
R43 FRSQSWSRGSPstVS
S45 SQSWSRGSPstVSSS
S47-p SWSRGSPstVSSSYK
S47 SWSRGSPStVSSSYK
T48-gl WSRGSPstVSSSYKR
T48 WSRGSPsTVSSSYKR
S50 RGSPstVSSSYKRSA
S51 GSPstVSSSYKRSAL
S52 SPstVSSSYKRSALA
K54 stVSSSYKRSALAPR
S74 AMLSSAESSLDFSQs
S81-p SSLDFSQsSsLLNGG
S83-p LDFSQsSsLLNGGsG
S89-p SsLLNGGsGGDyKLS
Y93-p NGGsGGDyKLSRSNE
S98 GDyKLSRSNEKEQLQ
K101 KLSRSNEKEQLQGLN
K117 RFAGYIEKVHYLEQQ
K126 HYLEQQNKEIEAEIH
K138 EIHALRQKQASHAQL
S141 ALRQKQASHAQLGDA
K167 LEMVNHEKAQVQLDS
S212 VRKDIEESSMVKVEL
S213 RKDIEESSMVKVELD
K222 VKVELDKKVQSLQDE
S225 ELDKKVQSLQDEVAF
K258 SHITVERKDYLKTDI
K262 VERKDYLKTDISTAL
K270 TDISTALKEIRSQLE
K292 HQAEEWFKCRYAKLT
K297 WFKCRYAKLTEAAEQ
K306 TEAAEQNKEAIRSAK
K313 KEAIRSAKEEIAEyR
Y319-p AKEEIAEyRRQLQSK
K326 yRRQLQSKsIELESV
S327-p RRQLQSKsIELESVR
K337 LESVRGTKESLERQL
S339 SVRGTKESLERQLsD
S345-p ESLERQLsDIEERHN
Y358-p HNHDLSSyQDTIQQL
Y383-p MARHLREyQDLLNVK
Y400-p LDIEIAAyRKLLEGE
K402 IEIAAyRKLLEGEET
S415 ETRFSTFSGsITGPL
S415 ETRFSTFSGsITGPL
S417-p RFSTFSGsITGPLyT
Y423-p GsITGPLyTHRQPsV
T424 sITGPLyTHRQPsVt
S429-p LyTHRQPsVtISSKI
S429 LyTHRQPSVtISSKI
T431-gl THRQPsVtISSKIQK
K435 PsVtISSKIQKTKVE
K438 tISSKIQKTKVEAPK
K445 KTKVEAPKLKVQHKF
K451 PKLKVQHKFVEEIIE
K461 EEIIEETKVEDEKsE
S467-p TKVEDEKsEMEDALT
T474 sEMEDALTVIAEELA
S483-p IAEELAAsAKEEKEE
K485 EELAAsAKEEKEEAE
S503-p EEPEVEKsPVKsPEA
S507-p VEKsPVKsPEAKEEE
S537-p EEDEGVKsDQAEEGG
S545-p DQAEEGGsEKEGssE
S550-p GGsEKEGssEKDEGE
S551-p GsEKEGssEKDEGEQ
T564-p EQEEEGEtEAEGEGE
K591 KVEEMAIKEEIKVEK
S604-p EKPEKAKsPVPKsPV
S609-p AKsPVPKsPVEEVKP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
A640 VEEKKEVAKEsPKEE
S643-p KKEVAKEsPKEEKVE
S667-p PDKKKAEsPVKEKAV
K672 AEsPVKEKAVEEMIT
A673 EsPVKEKAVEEMITI
T679 KAVEEMITITKSVKV
T681 VEEMITITKSVKVsL
K682 EEMITITKSVKVsLE
K685 ITITKSVKVsLEKDT
S687-p ITKSVKVsLEKDTKE
K690 SVKVsLEKDTKEEKP
K693 VsLEKDTKEEKPQQQ
K696 EKDTKEEKPQQQEKV
S713-p KAEEEGGsEEEVGDK
G718 GGsEEEVGDKsPQES
S721-p EEEVGDKsPQESKKE
S725 GDKsPQESKKEDIAI
T761 EEEKGVVTNGLDVsP
S767-p VTNGLDVsPAEEKKG
R777 EEKKGEDRSDDKVVV
K786 DDKVVVTKKVEkITS
K787 DKVVVTKKVEkITSE
K790-ub VVTKKVEkITSEGGD
T800 SEGGDGATKYITKSV
K801 EGGDGATKYITKSVT
Y802 GGDGATKYITKSVTV
K805 GATKYITKSVTVTQK
K840 VTSHAIVKEVTQGD_
T843 HAIVKEVTQGD____
  chicken

 
S2 ______MSYTMEPLG
T18 PSYRRVMTETRATYS
T20 YRRVMTETRATYSRA
T23 VMTETRATYSRASAS
R26 ETRATYSRASASPSS
S28 RATYSRASASPSSGF
S28 RATYSRASASPSSGF
S30 TYSRASASPSSGFRS
S33 RASASPSSGFRSQSW
S33 RASASPSSGFRSQSW
S37 SPSSGFRSQSWSRGS
S37 SPSSGFRSQSWSRGS
R42 FRSQSWSRGSGSTVS
R42 FRSQSWSRGSGSTVS
S44 SQSWSRGSGSTVSSS
S46 SWSRGSGSTVSSSYK
S46 SWSRGSGSTVSSSYK
T47 WSRGSGSTVSSSYKR
T47 WSRGSGSTVSSSYKR
S49 RGSGSTVSSSYKRTN
S50 GSGSTVSSSYKRTNL
S51 SGSTVSSSYKRTNLG
K53 STVSSSYKRTNLGAP
S74 TVLSSAESLDVSQSS
S80 ESLDVSQSSLLNGAA
- gap
A87 SSLLNGAAELKLSRS
L89 LLNGAAELKLSRSNE
S94 AELKLSRSNEKEQLQ
K97 KLSRSNEKEQLQGLN
K113 RFAGYIEKVHYLEQQ
K122 HYLEQQNKEIEAELA
K134 ELAALRQKHAGRAQL
G137 ALRQKHAGRAQLGDA
K163 LEQVSHEKAQIQLDS
A208 LRKEMEEASLMRAEL
S209 RKEMEEASLMRAELD
K218 MRAELDKKVQSLQDE
S221 ELDKKVQSLQDEVAF
K254 SHATVERKDYLKTDL
K258 VERKDYLKTDLTTAL
K266 TDLTTALKEIRAQLE
K288 HQAEEWFKCRYAKLT
K293 WFKCRYAKLTEAAEQ
K302 TEAAEQNKEAIRSAK
K309 KEAIRSAKEEIAEYR
Y315 AKEEIAEYRRQLQSK
K322 YRRQLQSKSIELESV
S323 RRQLQSKSIELESVR
K333 LESVRGTKESLERQL
S335 SVRGTKESLERQLSD
S341 ESLERQLSDIEERHN
Y354 HNNDLTTYQDTIHQL
Y379 MARHLREYQDLLNVK
Y396 LDIEIAAYRKLLEGE
K398 IEIAAYRKLLEGEET
S411 ETRFSAFSGSITGPI
S411 ETRFSAFSGSITGPI
S413 RFSAFSGSITGPIFT
F419 GSITGPIFTHRQPSV
T420 SITGPIFTHRQPSVT
S425 IFTHRQPSVTIASTK
S425 IFTHRQPSVTIASTK
T427 THRQPSVTIASTKIQ
K432 SVTIASTKIQKTKIE
K435 IASTKIQKTKIEPPK
K442 KTKIEPPKLKVQHKF
K448 PKLKVQHKFVEEIIE
K458 EEIIEETKVEDEKsE
S464-p TKVEDEKsEMEDALs
S471-p sEMEDALsAIAEEMA
K480 IAEEMAAKAQEEEQE
Q482 EEMAAKAQEEEQEEE
- gap
S502-p AVEEEAVsEKAAEQA
S528-p EEEEAAKsDAAEEGG
S536 DAAEEGGSKKEEIEE
I541 GGSKKEEIEEKEEGE
E542 GSKKEEIEEKEEGEE
A555 EEAEEEEAEAKGKAE
K593 SPVTEQAKAVQKAAA
K610 GKDQKAEKAAEKAAK
A615 AEKAAEKAAKEEKAA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T664 RSPEKPTTPEKVVSP
S688 RTPEKPASPEKPATP
A693 PASPEKPATPEKPRT
T694 ASPEKPATPEKPRTP
T700 ATPEKPRTPEKPATP
E702 PEKPRTPEKPATPEK
K703 EKPRTPEKPATPEKP
T706 RTPEKPATPEKPRSP
E708 PEKPATPEKPRSPEK
R711 PATPEKPRSPEKPSS
E714 PEKPRSPEKPSSPLK
S718 RSPEKPSSPLKDEKA
T737 SITVTKVTKVTAEVE
- gap
- gap
A749 EVEVSKEARKEDIAV
T781 EEEKGVVTNGLDVSP
S787 VTNGLDVSPVDEKGE
- gap
K800 GEKVVVTKKAEKITS
K801 EKVVVTKKAEKITSE
K804 VVTKKAEKITSEGGD
T814 SEGGDSTTTYITKSV
T815 EGGDSTTTYITKSVT
Y816 GGDSTTTYITKSVTV
K819 STTTYITKSVTVTQK
K854 VTSHAVVKEIKE___
K857 HAVVKEIKE______
  cow

 
S2 ______MSYTLDSLG
T18 PSAYRRVTETRSSFS
T20 AYRRVTETRSSFSRI
S23 RVTETRSSFSRISGS
R26 ETRSSFSRISGSPSS
S28 RSSFSRISGSPSSGF
S28 RSSFSRISGSPSSGF
S30 SFSRISGSPSSGFRS
S33 RISGSPSSGFRSQSW
S33 RISGSPSSGFRSQSW
S37 SPSSGFRSQSWSRGS
S37 SPSSGFRSQSWSRGS
R42 FRSQSWSRGSPSTVS
R42 FRSQSWSRGSPSTVS
S44 SQSWSRGSPSTVSSS
S46 SWSRGSPSTVSSSYK
S46 SWSRGSPSTVSSSYK
T47 WSRGSPSTVSSSYKR
T47 WSRGSPSTVSSSYKR
S49 RGSPSTVSSSYKRSA
S50 GSPSTVSSSYKRSAL
S51 SPSTVSSSYKRSALA
K53 STVSSSYKRSALAPR
S73 AMLSSAESSLDFSQS
S80 SSLDFSQSSSLLDGG
S82 LDFSQSSSLLDGGSG
S88 SSLLDGGSGPGGDYK
Y94 GSGPGGDYKLSRSNE
S99 GDYKLSRSNEKEQIQ
K102 KLSRSNEKEQIQGLN
K118 RFAGYIEKVHYLEQQ
K127 HYLEQQNKEIEAEIQ
K139 EIQALRQKQASHAQL
S142 ALRQKQASHAQLGDA
K168 LEMVNHEKAQVQLDS
S213 LRKDIEESSLVKVEL
S214 RKDIEESSLVKVELD
K223 VKVELDKKVQSLQDE
S226 ELDKKVQSLQDEVAF
K259 SHITVERKDYLKTDI
K263 VERKDYLKTDISTAL
K271 TDISTALKEIRSQLE
K293 HQAEEWFKCRYAKLT
K298 WFKCRYAKLTEAAEQ
K307 TEAAEQNKEAIRSAK
K314 KEAIRSAKEEIAEYR
Y320 AKEEIAEYRRQLQSK
K327 YRRQLQSKSIELESV
S328 RRQLQSKSIELESVR
K338 LESVRGTKESLERQL
S340 SVRGTKESLERQLSD
S346 ESLERQLSDIEERHN
Y359 HNHDLSSYQDTIQQL
Y384 MARHLREYQDLLNVK
Y401 LDIEIAAYRKLLEGE
K403 IEIAAYRKLLEGEET
A416 ETRFSTFAGSITGPL
A416 ETRFSTFAGSITGPL
S418 RFSTFAGSITGPLYT
Y424 GSITGPLYTHRQPSI
T425 SITGPLYTHRQPSIA
S430 LYTHRQPSIAISSKI
S430 LYTHRQPSIAISSKI
A432 THRQPSIAISSKIQK
K436 PSIAISSKIQKTKVE
K439 AISSKIQKTKVEAPK
K446 KTKVEAPKLKVQHKF
K452 PKLKVQHKFVEEIIE
K462 EEIIEETKVEDEKSE
S468 TKVEDEKSEMEEALT
T475 SEMEEALTAITEELA
S484 ITEELAVSVKEEVKE
K486 EELAVSVKEEVKEEE
S513-p EVVAAKKsPVKATAP
A517 AKKsPVKATAPELKE
S547-p EEEEAAKsDQAEEGG
S555-p DQAEEGGsEKEGSsE
S560 GGsEKEGSsEKEEGE
S561-p GsEKEGSsEKEEGEQ
T574 EQEEEGETEAEGEGE
K603 KAEEVAPKEELAAEA
S620 EKPEKAKSPVAKSPT
S625 AKSPVAKSPTtKsPT
T628-p PVAKSPTtKsPTAKs
S630-p AKSPTtKsPTAKsPE
S635-p tKsPTAKsPEAKsPE
S640-p AKsPEAKsPEAKSPt
T647-p sPEAKSPtAKsPTAK
S650-p AKSPtAKsPTAKsPV
S655-p AKsPTAKsPVAKSPT
- gap
S660 AKsPVAKSPTAKsPE
S665-p AKSPTAKsPEAKsPE
S670-p AKsPEAKsPEAKSPt
T677-p sPEAKSPtAKSPtAK
S680 AKSPtAKSPtAKsPA
T682-p SPtAKSPtAKsPAAK
S685-p AKSPtAKsPAAKSPA
S690 AKsPAAKSPAPKsPV
S695-p AKSPAPKsPVEEVKP
K703 PVEEVKPKAEAGAEK
K710 KAEAGAEKGEQKEKV
- gap
S727-p EKKEAKEsPKEEKAE
S751-p PEKKKAEsPVKAEsP
E756 AEsPVKAEsPVKEEV
S757-p EsPVKAEsPVKEEVP
V763 EsPVKEEVPAKPVKV
A765 PVKEEVPAKPVKVsP
K766 VKEEVPAKPVKVsPE
K769 EVPAKPVKVsPEKEA
S771-p PAKPVKVsPEKEAKE
K774 PVKVsPEKEAKEEEK
K777 VsPEKEAKEEEKPQE
K781 KEAKEEEKPQEKEKE
K798 KVEEVGGKEEGGLKE
L803 GGKEEGGLKESRKED
- gap
S806 EEGGLKESRKEDIAI
T841-p EEEKGVVtNGLDVsP
S847-p VtNGLDVsPGDEKKG
K857 DEKKGGDKSEEKVVV
K866 EEKVVVTKMVEKITS
M867 EKVVVTKMVEKITSE
K870 VVTKMVEKITSEGGD
T880 SEGGDGATKYITKSV
K881 EGGDGATKYITKSVT
Y882 GGDGATKYITKSVTV
K885 GATKYITKSVTVTQK
K920 VTSHAIVKEVTQSD_
T923 HAIVKEVTQSD____
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