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Protein Page:
SLC19A2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC19A2 High-affinity transporter for the intake of thiamine. Defects in SLC19A2 are the cause of thiamine-responsive megaloblastic anemia syndrome (TRMA); also known as Rogers syndrome. TRMA is an autosomal recessive disease with features that include megaloblastic anemia, mild thrombocytopenia and leucopenia, sensorineural deafness and diabetes mellitus. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Cellular Component: integral to membrane; plasma membrane
Molecular Function: folic acid transporter activity; protein binding; thiamin transmembrane transporter activity; thiamin uptake transmembrane transporter activity
Biological Process: vitamin metabolic process; thiamin and derivative metabolic process; thiamin transport; water-soluble vitamin metabolic process; folic acid transport
Reference #:  O60779 (UniProtKB)
Alt. Names/Synonyms: high affinity thiamine transporter; reduced folate carrier protein (RFC) like; S19A2; SLC19A2; solute carrier family 19 (thiamine transporter), member 2; Solute carrier family 19 member 2; TC1; Thiamine carrier 1; Thiamine transporter 1; THT1; ThTr-1; ThTr1; TRMA
Gene Symbols: SLC19A2
Molecular weight: 55,400 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Select Structure to View Below

SLC19A2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S8-p MDVPGPVsRRAAAAA
0 2 T17-p RAAAAAAtVLLRTAR
0 1 S222-p LFFHHIPsTCQRVNG
0 1 K256-ub GWEDIESkIPLNMEE
0 1 Y332-p PSRYAAIyNGGVEAV
0 1 K484-ub SVMKKCRkLEDPQsS
0 1 S490-p RkLEDPQsSsQVtTS
0 6 S492-p LEDPQsSsQVtTS__
0 1 T495-p PQsSsQVtTS_____
  mouse

 
S8 MDVPARVSRRAAAAA
R17 RAAAAAARMLLRTAR
S222 LFFHHIPSSCHGVNG
K256 GWEDIESKIPLNLDE
Y333 PSQNADIYNGGVEAV
K485 SIIKKCRKQEDPSSS
S491 RKQEDPSSSPQASTS
P493 QEDPSSSPQASTS__
S496 PSSSPQASTS_____
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